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    Photo AAPS 2024 - James on KORSCH booth

    MEDELPHARM's participation at AAPS PharmSci 360 2024: Innovations in tablet formulation

    Newsfeeds - 30/10/2024 - by Gabrielle Dupont
    At the recent AAPS PharmSci 360, held from October 20th-23rd, 2024, in Salt Lake City, MEDELPHARM showcased its latest advancements in tablet formulation technology alongside KORSCH America. This collaboration featured …
    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Newsfeeds - 29/08/2024 -
    The review provides an extensive overview of granulation techniques in pharmaceutical manufacturing, comparing traditional and modern methods. It details dry granulation techniques such as slugging, roller compaction, and pneumatic dry …
    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Papers - 04/06/2024 - by Allisson N. DuRoss, Kendall R. Pearson, Mark E. Waller, Hannah E. Worrest
    Problem Statement • Dry granulation (DG) demonstration batches consume large amounts of material and time • Spray dried intermediate (SDI) based tablets commonly require upstream dry granulation • Previous workflows …
    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Papers - 04/06/2024 - by Anil Kumar Vadaga, Sai Shashank Gudla, Gnanendra Sai Kumar Nareboina, Hymavathi Gubbala, Bhuvaneswari Golla
    This comprehensive review examines both modern and traditional granulation techniques in pharmaceutical dosage forms, with a particular focus on dry and wet granulation. The dry granulation methods covered include slugging, …
    tablets and powder heap

    Modified roller compaction model to account for roll speed effect on powder compaction in dry granulation process

    Papers - 07/05/2024 - by Indu Muthancheri, Mario Rousselin, Anna Espinose, Nicolas Sanchez, Jean-Rene Authelin
    This study presents an enhancement to the roller compaction model originally proposed by [1], incorporating the impact of roll speed on powder compaction during the dry granulation process. The updated …
    assorted single-layer tablets on grey background

    Mimicking dry granulation on the STYL'One Evo to improve flowability

    Bulletins - 16/04/2024 - by Sixtine Caquant, Adrien Pelloux
    Dry granulation is a commonly used process in the pharmaceutical industry. It provides several key advantages, including precise particle size control, improved flowability of powders, versatility in processing materials, increased …
    no-image

    Modeling of STYL'One Evolution correction factors for multicomponent mixtures scaling-up to roller compaction

    Papers - 11/04/2024 - by Fabia Arpago, Agostino Dall'Ara
    Roll compaction (RC) stands as a cost-efficient dry granulation technique extensively utilized in the pharmaceutical sector. In the initial stages of formulation development, particularly when resources are constrained, the ability …
    image twin screw granulation process

    A QbD guided development of a Twin-Screw Granulation process

    Newsfeeds - 12/03/2024 -
    The text discusses dry granulation techniques in the pharmaceutical industry, focusing on roller compaction and slugging, highlighting their limitations such as inferior tablet strength and reduced yield due to fine …
    Material-Sparing-Method-for-Dry-Granulation.original

    Dry granulation a material sparing method

    White Papers - 01/08/2023 - by Bruno Villa
    Granulation of pharmaceutical powder is often required to prevent segregation of the Active Pharmaceutical Ingredient (API) and/or to enhance the blend flowability, which is critical to ensure consistent tablet mass …
    no-image

    Effect of process parameters, protectants and carrier materials on the survival of yeast cells during fluidized bed granulation for tableting

    Papers - 09/03/2023 - by Karl Vorländer, Lukas Bahlmann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    This study focuses on the drying of Saccharomyces cerevisiae, a yeast variety that includes the probiotic Saccharomyces boulardii. Ensuring microbial viability is crucial for effective dosage forms, especially for probiotics …
    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    Papers - 07/08/2022 - by Maarten Jaspers, Timo P. Roelofs, Pauline H.M. Janssen, Robin Meier, Bastiaan H.J. Dickhoff
    Roller compaction for dry granulation is gaining popularity as a method for producing oral solid dosage forms. The process offers simplicity compared to wet granulation and operates inherently in a …
    Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa

    Pharmaceutical development of film-coated mini-tablets with losartan potassium for Epidermolysis Bullosa

    Papers - 05/03/2022 - by Valentinë Elezaj, Ard Lura, Luis Canha, Jörg Breitkreutz
    Epidermolysis bullosa is a genetically heterogeneous skin fragility disorder that manifests with multiorgan involvement, often evident in newborn children. The condition leads to severe progressive fibrosis following skin blistering, mucosal …