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    Yellow and white tablets on pink background

    Determination of ribbon solid fraction in roll compaction using ibuprofen DC100

    Newsfeeds - 14/04/2025 -
    The study titled "Determination of Ribbon Solid Fraction in Roll Compaction using Ibuprofen DC100" focuses on developing a Process Analytical Technology (PAT) for in-line measurement of ribbon solid fraction during …
    Influence of material and process parameters on the correction factor Kp in roller compaction simulation

    Influence of material and process parameters on the correction factor Kp in roller compaction simulation

    Papers - 05/04/2025 - by Layla Hassan, René Jensen, Zahra Sodal, Frederik Hellesøe Ørtoft, Lasse I. Blaabjerg, Umair Zafar
    It is commonly accepted that compaction simulators can mimic the uniaxial compression process of roller compactors. To align the simulation output with actual product relative density, a correction factor (Kp) …
    A study on the pelletization and solidification of Cs-contaminated soil after soil washing

    A study on the pelletization and solidification of Cs-contaminated soil after soil washing

    Papers - 01/06/2023 - by Jun-Yeol An, Ki-Tae Yang, Min-Ho Lee, Sang-Hyun Lim, Sun-Il Kim, Jong-Soon Song
    The release of radioactive substances during a nuclear power plant accident can result in soil contamination over a wide area. Soil washing, employed as a decontamination technique for cesium (Cs)-contaminated …
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    A study on the pelletization and solidification of Cs-contaminated soil after soil washing

    Papers - 01/06/2023 -
    Radioactive substances released as nuclear power plant accident can contaminate soil in a wide area. Soil washing is used as decontamination technique for Cs-contaminated soil, which exhibits short processing time …
    Solidification of radioactive soil waste through volume reduction and stabilization: Characteristic evaluation and waste acceptance criteria satisfaction

    Solidification of radioactive soil waste through volume reduction and stabilization: Characteristic evaluation and waste acceptance criteria satisfaction

    Papers - 01/05/2023 - by Sang-Hyun Lim, Sang-Heon Lee, Jong-Soon Song, Ki-Hong Kim
    The disposal of radioactive soil waste poses a global environmental challenge, necessitating effective management strategies. To address this issue, pelletization technology can be employed to reduce the physical volume of …
    20211027_Webinar_Dry_Granulation_Mimicking_FINAL Slides Medelpharm + Hannah Lou

    Dry granulation formulation development

    Webinar Replays - 27/10/2021 - by Hannah Lou Keiser, Bruno Leclercq
    Hannah Lou Keizer (Doctorate at Heinrich Heine University Düsseldorf ), Bruno Leclercq and Adrien Pelloux (MEDELPHARM) share on Dry Granulation Formulation Development and Roll Compaction mimicking.
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    Recent progress in roll compaction process development for pharmaceutical solid dosage form manufacture

    Papers - 11/06/2020 - by Ariel R. Muliadi, Alamelu Banda, Chen Mao
    Over the past decade, roll compaction technologies have seen significant advancements, becoming increasingly favored by formulation scientists for granulation purposes. This chapter provides an overview of recent developments in pharmaceutical …
    Elastic recovery in roll compaction simulation

    Elastic recovery in roll compaction simulation

    Papers - 01/01/2020 - by Hannah L. Keizer, Peter Kleinebudde
    Roll compaction/dry granulation stands as a widely employed method in the pharmaceutical sector for granulation. Particularly in the initial stages of solid dosage form formulation development, simulating this process is …
    Estimation of nip angle by roll compaction simulation

    Estimation of nip angle by roll compaction simulation

    Papers - 01/06/2019 - by H L Keizer, P Kleinebudde
    On a roll compactor (RC), the space between the rolls is segmented into a slip, a compaction, and a release zone. The angle formed between the start and the end …
    How relevant is ribbon homogeneity in roll compaction/dry granulation and can it be influenced?

    How relevant is ribbon homogeneity in roll compaction/dry granulation and can it be influenced?

    Papers - 01/12/2018 - by Raphael Wiedey, Rok Šibanc, Annika Wilms, Peter Kleinebudde
    The conventional belief suggests that achieving a uniform distribution of the solid fraction in ribbons is advantageous during roll compaction/dry granulation. Many efforts have been made to enhance this uniformity …
    riblets MEDELPHARM

    Impact of roll compaction design, process parameters, and material deformation behaviour on ribbon relative density

    Papers - 03/08/2018 - by Kitti Csordas, Raphael Wiedey, Peter Kleinebudde
    Ribbons comprising microcrystalline cellulose (MCC), mannitol, and a 50:50% mixture of both were generated utilizing the roll compactors AlexanderWerk BT120, Hosokawa Alpine Pharmapaktor C250, L.B. Bohle BRC 25, and Gerteis …
    Roll compaction and tableting of high loaded Metformin formulations using efficient binders

    Roll compaction and tableting of high loaded Metformin formulations using efficient binders

    Papers - 01/07/2018 - by Oscar-Rupert Arndt, Peter Kleinebudde
    Metformin is known for its poor tabletability and flowability, typically requiring wet granulation with a binder prior to tableting. To enhance cost-effectiveness, there is a desire to implement a roll …