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    Magnesium Stearate Fatty Acid Composition, Lubrication Performance and Tablet Properties

    Magnesium Stearate fatty acid composition, lubrication performance and tablet properties

    Papers - 05/11/2024 - by Natalia Veronica, Paul Wan Sia Heng, Celine Valeria Liew
    This research paper investigates the impact of different fatty acid compositions in magnesium stearate (MgSt), a common tablet lubricant, on tablet properties. The study focused on the significance of stearate …
    Selection of lubricant type and concentration for orodispersible tablets

    Selection of lubricant type and concentration for orodispersible tablets

    Papers - 25/05/2024 - by Audrey Yi Zheng, Mahn Teng Loh, Paul Wan Sia Heng, Lai Wah Chan
    Lubricants play a vital role in most tablet formulations by aiding powder flow, preventing adhesion to tableting tools, and facilitating tablet ejection. Although magnesium stearate (MgSt) is commonly used as …
    Tableting behavior of freeze and spray-dried excipients in pharmaceutical formulations

    Tableting behavior of freeze and spray-dried excipients in pharmaceutical formulations

    Papers - 10/05/2024 - by Charbel Madi, Hassana Hsein, Virginie Busignies, Pierre Tchoreloff, Vincent Mazel
    Liquid biopharmaceuticals often face stability challenges during storage, making their preservation a priority. Among the various drying techniques employed in the pharmaceutical industry to enhance stability, lyophilization stands out as …
    Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature on the granule and tablet properties

    Twin-screw melt granulation with PEG 8000: effect of binder particle size and processing temperature on the granule and tablet properties

    Papers - 18/03/2024 - by Zoltán Márk Horváth, Liga Lauberte, Valentyn Mohylyuk
    The aim of this study was to investigate the effect of PEG 8000 particle size and twin-screw melt granulation temperature on the properties of resultant MCC-CaHPO4 granules and their tablets.
    Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity

    Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity

    Papers - 28/02/2024 - by Gerrit Vreeman, Danyingzi Guan, Yuncheng Cai, Qun Zhou, Changquan Calvin Sun
    Cocrystallization proves to be a potent technique for modifying the tableting performance of crystals by adjusting their mechanical attributes. This research delves into the cocrystallization of ligustrazine (LIG) with malonic …
    Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive formulations

    Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive formulations

    Papers - 15/12/2023 - by Hanna Dorothea Grumann, Peter Kleinebudde
    The process of tableting involves transforming mechanical energy into thermal energy. This study assessed how temperature affects the tableting characteristics of formulations with varying compositions. A tableting machine equipped with …
    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Papers - 08/12/2023 - by Natalia Veronica, Yi Ying Loh, Lydia Xiu Ying Loh, Paul Wan Sia Heng, Celine Valeria Liew
    Investigating the heat sensitivity of frequently used excipients with varying particle sizes

    Investigating the heat sensitivity of frequently used excipients with varying particle sizes

    Papers - 01/11/2023 - by Hanna Dorothea Grumann, Peter Kleinebudde
    In the course of tablet manufacturing, an elevation in production temperature can result in changes to tablet characteristics. This study explores the impact of the initial particle size on the …
    Effect of geometrical features on the capping behavior of biconvex tablets

    Effect of geometrical features on the capping behavior of biconvex tablets

    Papers - 03/09/2023 - by Vincent Mazel, Cléo Garcia, Pierre Tchoreloff
    Capping is a prevalent issue in the pharmaceutical tablet manufacturing process, influenced by both process and formulation parameters. This study systematically examined the impact of the geometrical features of biconvex …
    Comparison of scale-up strategies in twin-screw wet granulation

    Comparison of scale-up strategies in twin-screw wet granulation

    Papers - 25/06/2023 - by Marcel Franke, Thomas Riedel, Robin Meier, Carsten Schmidt, Peter Kleinebudde
    This study aimed to evaluate different scale-up strategies in twin-screw wet granulation and assess their impact on granule and tablet properties for a specific formulation. The granulation process was transitioned …
    Upscaling of external lubrication from a compaction simulator to a rotary tablet press

    Upscaling of external lubrication from a compaction simulator to a rotary tablet press

    Papers - 01/01/2023 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with …
    Screening of lubricants towards their applicability for external lubrication

    Screening of lubricants towards their applicability for external lubrication

    Papers - 28/12/2022 - by Cedrine de Backere, Margot Surmont, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    Decreasing tensile strength and prolonged disintegration are linked to internal lubrication. These adverse effects can be mitigated by employing external lubrication. In this present investigation, a compaction simulator was utilized …