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    Photo AAPS 2024 - James on KORSCH booth

    MEDELPHARM's participation at AAPS PharmSci 360 2024: Innovations in tablet formulation

    Newsfeeds - 30/10/2024 - by Gabrielle Dupont
    At the recent AAPS PharmSci 360, held from October 20th-23rd, 2024, in Salt Lake City, MEDELPHARM showcased its latest advancements in tablet formulation technology alongside KORSCH America. This collaboration featured …
    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Newsfeeds - 29/08/2024 -
    The review provides an extensive overview of granulation techniques in pharmaceutical manufacturing, comparing traditional and modern methods. It details dry granulation techniques such as slugging, roller compaction, and pneumatic dry …
    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Papers - 04/06/2024 - by Anil Kumar Vadaga, Sai Shashank Gudla, Gnanendra Sai Kumar Nareboina, Hymavathi Gubbala, Bhuvaneswari Golla
    This comprehensive review examines both modern and traditional granulation techniques in pharmaceutical dosage forms, with a particular focus on dry and wet granulation. The dry granulation methods covered include slugging, …
    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Papers - 04/06/2024 - by Allisson N. DuRoss, Kendall R. Pearson, Mark E. Waller, Hannah E. Worrest
    Problem Statement • Dry granulation (DG) demonstration batches consume large amounts of material and time • Spray dried intermediate (SDI) based tablets commonly require upstream dry granulation • Previous workflows …
    Modified roller compaction model to account for roll speed effect on powder compaction in dry granulation process

    Modified roller compaction model to account for roll speed effect on powder compaction in dry granulation process

    Papers - 07/05/2024 - by Indu Muthancheri, Mario Rousselin, Anna Espinose, Nicolas Sanchez, Jean-Rene Authelin
    This study presents an enhancement to the roller compaction model originally proposed by [1], incorporating the impact of roll speed on powder compaction during the dry granulation process. The updated …
    Mimicking dry granulation on the STYL'One Evo to improve flowability

    Mimicking dry granulation on the STYL'One Evo to improve flowability

    Bulletins - 16/04/2024 - by Sixtine Caquant, Adrien Pelloux
    Dry granulation is a commonly used process in the pharmaceutical industry. It provides several key advantages, including precise particle size control, improved flowability of powders, versatility in processing materials, increased …
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    Modeling of STYL'One Evolution correction factors for multicomponent mixtures scaling-up to roller compaction

    Papers - 11/04/2024 - by Fabia Arpago, Agostino Dall'Ara
    Roll compaction (RC) stands as a cost-efficient dry granulation technique extensively utilized in the pharmaceutical sector. In the initial stages of formulation development, particularly when resources are constrained, the ability …
    image twin screw granulation process

    A QbD guided development of a Twin-Screw Granulation process

    Newsfeeds - 12/03/2024 -
    The text discusses dry granulation techniques in the pharmaceutical industry, focusing on roller compaction and slugging, highlighting their limitations such as inferior tablet strength and reduced yield due to fine …
    Material-Sparing-Method-for-Dry-Granulation.original

    Dry granulation a material sparing method

    White Papers - 01/08/2023 - by Bruno Villa
    Granulation of pharmaceutical powder is often required to prevent segregation of the Active Pharmaceutical Ingredient (API) and/or to enhance the blend flowability, which is critical to ensure consistent tablet mass …
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    Effect of process parameters, protectants and carrier materials on the survival of yeast cells during fluidized bed granulation for tableting

    Papers - 09/03/2023 - by Karl Vorländer, Lukas Bahlmann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    This study focuses on the drying of Saccharomyces cerevisiae, a yeast variety that includes the probiotic Saccharomyces boulardii. Ensuring microbial viability is crucial for effective dosage forms, especially for probiotics …
    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    Papers - 07/08/2022 - by Maarten Jaspers, Timo P. Roelofs, Pauline H.M. Janssen, Robin Meier, Bastiaan H.J. Dickhoff
    Roller compaction for dry granulation is gaining popularity as a method for producing oral solid dosage forms. The process offers simplicity compared to wet granulation and operates inherently in a …
    Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa

    Pharmaceutical development of film-coated mini-tablets with losartan potassium for Epidermolysis Bullosa

    Papers - 05/03/2022 - by Valentinë Elezaj, Ard Lura, Luis Canha, Jörg Breitkreutz
    Epidermolysis bullosa is a genetically heterogeneous skin fragility disorder that manifests with multiorgan involvement, often evident in newborn children. The condition leads to severe progressive fibrosis following skin blistering, mucosal …