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    orally disintegrating tablets

    Excipients for orally disintegrating tablets: compaction data analysis and study of tableting properties of lubricated co-processed excipients

    Papers - 04/09/2023 - by Mayowa Onayo, Yildiz Ozalp, Nailla Jiwa, Burcu Mesut, Sevgi Gungor
    The selection of an appropriate co-processed excipient (CPE) is a critical aspect in the development of orally disintegrating tablets (ODTs). This study assessed five commonly used CPEs (Ludiflash®, Ludipress®, Ludipress® …
    Influence of the drug deformation behaviour on the predictability of compressibility and compactibility of binary mixtures

    Influence of the drug deformation behaviour on the predictability of compressibility and compactibility of binary mixtures

    Papers - 17/08/2022 - by Isabell Wünsch, Jan Henrik Finke, Edgar John, Michael Juhnke, Arno Kwade
    Numerous studies have sought to understand the predictability of compressibility and compactibility in tablet formulations by examining the behavior of individual materials. However, the complexity of the powder compaction process …
    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    Papers - 07/08/2022 - by Maarten Jaspers, Timo P. Roelofs, Pauline H.M. Janssen, Robin Meier, Bastiaan H.J. Dickhoff
    Roller compaction for dry granulation is gaining popularity as a method for producing oral solid dosage forms. The process offers simplicity compared to wet granulation and operates inherently in a …
    MEDELPHARM Science Lab powder angle of repose

    Assess the impact of your granulation process parameters with the STYL'One Evo

    Bulletins - 01/03/2022 - by Sixtine Caquant, Adrien Pelloux
    Powder granulation is commonly used in the pharmaceutical industry to improve flowability and compactibility of powders. In this case our customer wanted to develop a new directcompression grade of excipient …
    White oblong tablets

    Evaluation of tableting performance of poly (ethylene oxide) in abuse-deterrent formulations using compaction simulation studies

    Papers - 15/03/2021 - by Dongyue Yu, Raghunadha Reddy Seelam, Feng Zhang, Stephen R. Byrn, Stephen W. Hoag
    Poly (ethylene oxide) (PEO) is extensively employed in abuse-deterrent formulations (ADFs) to enhance tablet hardness. Previous research has demonstrated that various formulation factors, such as processing conditions and the particle …
    Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution

    Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution

    Papers - 01/10/2019 - by Kristina E. Steffens, Karl G. Wagner
    This study investigated how the tabletability and compactibility of granules, formed through twin-screw melt granulation, are influenced by the distribution of binders. Two grades of dicalcium phosphate anhydrous (fine and …
    Determination of the solid (“true”) density of pharma- ceutical powders and the impact on tablet compression characterization

    Determination of the solid (“true”) density of pharma- ceutical powders and the impact on tablet compression characterization

    Papers - 11/04/2019 - by E John, T Höltkemeier, A Grandeury, M Juhnke, J H Finke, I Wünsch, A Kwade
    The characterization and development of a tableting process commonly involve investigating compressibility (porosity vs compression stress), tabletability (tensile strength vs compression stress), and compactibility (tensile strength vs porosity), as outlined …
    Roller compaction: application of an in-gap ribbon porosity calculation for the optimization of downstream granule flow and compactability characteristics

    Roller compaction: application of an in-gap ribbon porosity calculation for the optimization of downstream granule flow and compactability characteristics

    Papers - 01/06/2010 - by John F. Gamble, Michael Tobyn, Andrew B. Dennis, Trupty Shah
    This paper discusses the utilization of an in-gap ribbon porosity calculation to optimize roller compaction ribbon parameters, aiming to regulate downstream granule and tablet properties in a typical pharmaceutical formulation. …