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    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Newsfeeds - 29/08/2024 -
    The review provides an extensive overview of granulation techniques in pharmaceutical manufacturing, comparing traditional and modern methods. It details dry granulation techniques such as slugging, roller compaction, and pneumatic dry …
    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Papers - 04/06/2024 - by Anil Kumar Vadaga, Sai Shashank Gudla, Gnanendra Sai Kumar Nareboina, Hymavathi Gubbala, Bhuvaneswari Golla
    This comprehensive review examines both modern and traditional granulation techniques in pharmaceutical dosage forms, with a particular focus on dry and wet granulation. The dry granulation methods covered include slugging, …
    Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters

    Studying the API distribution of controlled release formulations produced via continuous twin-screw wet granulation: influence of matrix former, filler and process parameters

    Papers - 28/02/2024 - by Phaedra Denduyver, Chris Vervaet, Valérie Vanhoorne
    Hydroxypropyl methylcellulose (HPMC) stands out as the favored hydrophilic matrix former in the production of controlled release formulations via continuous twin-screw wet granulation. However, previous observations have highlighted a challenge: …
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    Scale-up in Twin-screw wet granulation: Impact of formulation properties

    Papers - 27/10/2023 - by Marcel Franke, Thomas Riedel, Robin Meier, Carsten Schmidt, Peter Kleinebudde
    This study aimed to explore the responsiveness of various drug formulations to differences in process parameters based on previously established scale-up strategies. Three distinct formulations were employed for scale-up experiments, …
    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Papers - 10/03/2021 - by Lise Vandevivere
    The investigation focused on evaluating the appropriateness of pharmaceutical binders for continuous twin-screw wet granulation, reflecting the pharmaceutical industry's shift from batch to continuous manufacturing. A comparison was conducted between …
    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Papers - 03/02/2021 - by Lise Vandevivere, Maxine Vangampelaere, Christoph Portier, Cedrine de Backere, Olaf Häusler, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    The appropriateness of pharmaceutical binders for continuous twin-screw wet granulation was examined, aligning with the pharmaceutical industry's transition from batch to continuous manufacturing. A scientific approach to binder selection is …
    BRC_100_033 - L.B. Bohle

    Roller compaction: new trends, challenges and solutions

    Newsfeeds - 12/11/2020 -
    This article explains the 3 known technologies to develop tablets:- direct compression- wet granulation- dry granulation, with a focus on roller compaction, as it remains an effective solution for most …
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    Development and pharmaceutical performance of a novel co-processed excipient of alginic acid and microcrystalline cellulose

    Papers - 10/10/2020 - by R. Benabbas, N.M. Sanchez-Ballester, B. Bataille, T. Sharkawi, I. Soulairol
    In this investigation, a co-processed excipient (Cop AA-MCC) was formulated through the combination of alginic acid (AA) and microcrystalline cellulose (MCC101) using a high-shear granulator on a laboratory scale. The …
    Advantages of Mannitol in Pharmaceutical Granulation Processes - bulletin

    Advantages of mannitol in pharmaceutical granulation processes - a comparison of different polymorphic forms

    Bulletins - 01/09/2020 - by Hans-Leonhard Ohrem
    The success of a wet granulation process depends on use of an excipient with excellent binding and compaction properties. Mannitol is frequently used for this purpose in solid dosage formulations …
    A study on the formulation of plant matrix tablets from coarse botanical materials using cinnamon bark and areca nut as the model botanical materials

    A study on the formulation of plant matrix tablets from coarse botanical materials using cinnamon bark and areca nut as the model botanical materials

    Papers - 30/08/2020 - by National University of Singapore Singapore, Natalia Veronica, Xiu Hui Ang, Shing Ming Ooi, Celine Valeria Liew, Paul Wan Sia Heng
    There is considerable interest in formulating tablets with botanical materials, primarily due to their compactness and ease of administration. However, the tableting of coarsely milled botanical materials presents challenges owing …
    Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

    Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

    Papers - 30/07/2020 - by L. Vandevivere, P. Denduyver, C. Portier, O. Häusler, T. De Beer, C. Vervaet, V. Vanhoorne
    The impact of various binders on the quality of granules produced through continuous twin-screw wet granulation was investigated. Anhydrous dicalcium phosphate served as a poorly soluble filler, and binders were …
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    Impact of different dry and wet granulation techniques on granule and tablet properties: a comparative study

    Papers - 01/12/2018 - by Oscar-Rupert Arndt, Roberto Baggio, Anna Kira Adam, Julia Harting, Erica Franceschinis, Peter Kleinebudde
    A comparative analysis was conducted on four granulation techniques to assess their impact on granule properties and tablet tensile strength. A common formulation was selected for processing through wet and …
    Influence of spray nozzle aperture during high shear wet granulation on granule properties and its compression attributes

    Influence of spray nozzle aperture during high shear wet granulation on granule properties and its compression attributes

    Papers - 01/12/2018 - by Natalia Veronica, Hui Ping Goh, Christina Yong Xin Kang, Celine Valeria Liew, Paul Wan Sia Heng
    The distribution of granulating liquid is acknowledged to influence the high shear wet granulation process, but the impact of spray nozzle attributes remains unclear. While a spray nozzle can achieve …
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    Quantitative assessment of mass flow boundaries in continuous twin-screw granulation

    Papers - 14/09/2016 - by Adrian Schmidt, Hans de Waard, Klaus-Peter Moll, Markus Krumme, Peter Kleinebudde
    In the realm of pharmaceutical manufacturing, there is a growing interest in continuous manufacturing. This study focuses on enhancing the comprehension of twin-screw wet granulation as an example of a …
    Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium

    Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium

    Papers - 19/05/2015 - by Matthew Roberts, Lia Pulcini, Shabbir Mostafa, Yvonne Cuppok-Rosiaux, Delphine Marchaud
    The preparation of lipophilic matrix tablets for the sustained release of water-soluble drugs through direct compression may face challenges due to poor flow and rapid drug release. This study aimed …
    Processing challenges with solid dosage formulations containing vitamin E TPGS

    Processing challenges with solid dosage formulations containing vitamin E TPGS

    Papers - 01/02/2013 - by Preetanshu Pandey, Patrick D. Sinko, Dilbir S. Bindra, Rhye Hamey, Shruti Gour, Chandra Vema-Varapu
    This study aims to explore the challenges associated with incorporating Vitamin E TPGS (d-α tocopheryl polyethylene glycol 1000 succinate) into solid pharmaceutical dosage forms. Employing a wet granulation process involving …
    A combined experimental and modeling approach to study the effects of high-shear wet granulation process parameters on granule characteristics

    A combined experimental and modeling approach to study the effects of high-shear wet granulation process parameters on granule characteristics

    Papers - 01/02/2013 - by Preetanshu Pandey, Jing Tao, Anwesha Chaudhury, Rohit Ramachandran, Julia Z. Gao, Dilbir S. Bindra
    The current study aims to investigate the impact of high-shear wet granulation process parameters on granule characteristics through a combination of experimental and modeling approaches. A full factorial design of …