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Current State of Minitablet Product Design: A Review

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Over the past two decades, there has been a remarkable surge in interest surrounding minitablets (MTs), particularly within the last ten years, as evidenced by the plethora of publications documented in Scopus and PubMed. MTs present significant prospects for personalized medicine, facilitating dose titration and adaptable dosing, taste concealment, and tailoring drug delivery systems. Progress in specialized MT tooling, manufacturing techniques, and instrumentation for characterization has effectively addressed many earlier developmental challenges. Groundbreaking research on MT swallowability, acceptability, and palatability has questioned the conventional notion that only liquid formulations are suitable for infants and young children. Minitablets have demonstrated high acceptability among infants, small children, and elderly patients with swallowing difficulties. This review delves into the current landscape of MT applications, their acceptance among pediatric and geriatric populations, medication adherence, manufacturing processes including tableting and coating, powder and tablet characterization methods, packaging and dispensing of MTs, as well as regulatory considerations.
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Current State of Minitablet Product Design: A Review

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