Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets
Sept. 26, 2023, midnight
Jan Henrik Finke
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Tablets are frequently manufactured by incorporating particulate lubricants internally, a practice that is recognized for its potential to diminish the mechanical strength of the tablets. This decline is attributed to the coating of matrix-forming components by lubricant particles, leading to a reduction in interparticulate interactions. Given the acknowledged incompatibilities of the widely used lubricant, magnesium stearate, with certain active compounds, there is a need for comprehensive characterization of alternative lubricants.