Scientific papers

Explore a selection of scientific papers featuring research conducted with STYL’One Compaction Simulators. Discover how leading scientists and institutions use STYL’One technology to advance understanding in powder compression, tablet formulation development, and process innovation.

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59 results

Date

Formulation handbook from Merck

Newsfeed - 02/10/2025 -

Formulating the perfect dosage form is no easy task. With so many techniques and excipients available, every decision made during development can influence the performance and success of the final …

Advancing pharmaceutical R&D at Tabletting School 2025: MEDELPHARM and KORSCH lead hands-on workshops at De Montfort University

Newsfeed - 04/07/2025 -

From June 17–18, 2025, MEDELPHARM and KORSCH proudly returned as expert contributors to the Tabletting School hosted by De Montfort University (DMU) in Leicester, UK. With its hands-on format and …

Evaluation of time-dependent deformation behavior of pharmaceutical excipients in the tableting process

Papers - 22/03/2025 - by Daisuke Mizunaga, Satoru Watano

Tableting is a crucial process in pharmaceutical manufacturing that directly impacts product quality. Maintaining consistent quality from the research and development phase to full-scale production is essential during scale-up. In …

Partnership with knowledge gain – on both sides

Newsfeed - 26/11/2024 -

The partnership between KORSCH, MEDELPHARM, and the Institute of Particle Technology (iPAT) at the Technical University of Braunschweig focuses on advancing tableting technologies and understanding powder behavior through collaborative research. …

KORSCH bringing to PMEC India tabletting solutions from R&D to high-speed production

Newsfeed - 25/11/2024 -

KORSCH Highlights Innovation at PMEC India 2024Berlin-based tablet compression leader KORSCH AG will showcase its cutting-edge technologies at PMEC India 2024, held at the India Expo Centre, Greater Noida, under …

A recipe for success: mastering tableting requires understanding ingredient attributes

Newsfeed - 12/09/2024 -

The author discusses the importance of understanding ingredient attributes in the process of tablet manufacturing. It emphasizes that consistently producing high-quality tablets requires more than just creating a successful small-scale …

Saving time and money by selecting the correct anti-abrasive solution

Whitepapers - 28/08/2024 -

Thompson & Capper is a contract manufacturer of pharmaceutical and nutritional tablets, based in the UK. They produce over 2.5 billion tablets every year, mainly for clients in Europe.Thompson & …

Image effect of glidant on tabletting behavior

The effect of glidant on the tabletting behavior of common pharmaceutical excipients

Newsfeed - 09/08/2024 -

The article on Pharma Excipients discusses the impact of glidants on the tabletting process in pharmaceutical manufacturing. Glidants are substances added to improve the flow properties of powders during tablet …

Dwell time on tableting: dwell time according to force versus geometric dwell time

Papers - 24/07/2024 - by Valentyn Mohylyuk

Dwell time is a key parameter influencing the material deformation and the mechanical and biopharmaceutical properties of a tablet, making it essential for scale-up processes. Geometric dwell time (GDT) can …

Image MEDELPHARM STYL'One Nano for early-stage characterization

STYL’One Nano R&D compaction simulator for early-stage material characterization and development

Newsfeed - 13/06/2024 -

The MEDELPHARM STYL’One Nano is a compact and advanced compaction simulator designed for early-stage tablet formulation in research and development. It helps researchers address formulation challenges in tablet and oral …

The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

Papers - 22/02/2024 - by Dongyue Yu, Stephen W. Hoag

The amorphous solid dispersion (ASD) method proves effective in enhancing the solubility, dissolution, and bioavailability of poorly water-soluble medications. However, these forms are prone to transitioning into more thermodynamically stable, …

Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: compaction, dissolution, and physical stability

Papers - 25/01/2024 - by Dongyue Yu, Haichen Nie, Stephen W. Hoag

The amorphous solid dispersion (ASD) method is a well-established approach to enhance the solubility and bioavailability of poorly soluble drugs. Although a significant number of ASD products are in tablet …

Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

Papers - 07/01/2024 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Bindhumadhavan Gururajan, Supriya Rane, Arno Kwade

Most tablets produced include lubricants to minimize friction during ejection. However, in the case of plastically deforming materials such as microcrystalline cellulose (MCC), internal incorporation of lubricants is known to …

Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

Papers - 08/12/2023 - by Natalia Veronica, Yi Ying Loh, Lydia Xiu Ying Loh, Paul Wan Sia Heng, Celine Valeria Liew

Self-driving tableting DataFactory

Webinar Replays - 07/12/2023 - by Daniel Markl, Bruno Leclercq

"Self-driving tableting DataFactory"- with guest speaker Daniel Markl, reader at the University of Strathclyde and Associate Director at the CMAC Center for Continuous Manufacturing and Advanced CrystallisationTraditional methods of developing …

Extended Dwell Flat (XDF) tooling at IHolland

Timing is key in tabletting

Whitepapers - 29/11/2023 -

Why you need to get your timing right to make better tabletsNeed to mass-produce tablets with quality solid dosage in a quick and cost-effective way? The time that a formulation …

Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

Papers - 11/11/2023 - by Hassana Hsein, Charbel Madi, Vincent Mazel, Pierre Tchoreloff, Virginie Busignies

The preferred method for enhancing the stability and storage conditions of biopharmaceutical products is freeze-drying. Typically, these freeze-dried products are designed for administration via the parenteral route. However, many parenterally …