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    Image - Article I Holland GR lanes

    Working with GR Lanes Health Products Ltd.

    White Papers - 23/04/2024 -
    Lanes, is a leading UK family-owned pharmaceutical company that specialises in producing natural remedies and is famous for brands such as Olbas and Kalms. Market leading products like these demand …
    Take-off sensor as a tool for sticking assessment during tablet development

    Take-off sensor as a tool for sticking assessment during tablet development

    Papers - 21/03/2024 - by Adrien Pelloux, Delphine Ach-Hubert, Sixtine Caquant
    More than 70% of candidate drugs have low solubility (BCS Class II and IV) (Nikolakakis et al. 2017). Making tablets with low solid fraction improves the dissolution rate (Van der …
    Galenic laboratory Armor - video screen

    See the Galenic Laboratory at Armor Pharma

    Newsfeeds - 15/03/2024 -
    Since 2020, Armor Pharma has made significant investments in a cutting-edge galenic laboratory, enhancing their expertise as a leading pharmaceutical lactose provider.Check out the latest video showcasing Armor Pharma's State-of-the-art …
    The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

    The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

    Papers - 22/02/2024 - by Dongyue Yu, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method proves effective in enhancing the solubility, dissolution, and bioavailability of poorly water-soluble medications. However, these forms are prone to transitioning into more thermodynamically stable, …
    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

    Papers - 25/01/2024 - by Dongyue Yu, Haichen Nie, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method is a well-established approach to enhance the solubility and bioavailability of poorly soluble drugs. Although a significant number of ASD products are in tablet …
    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Papers - 07/01/2024 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Bindhumadhavan Gururajan, Supriya Rane, Arno Kwade
    Most tablets produced include lubricants to minimize friction during ejection. However, in the case of plastically deforming materials such as microcrystalline cellulose (MCC), internal incorporation of lubricants is known to …
    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Papers - 08/12/2023 - by Natalia Veronica, Yi Ying Loh, Lydia Xiu Ying Loh, Paul Wan Sia Heng, Celine Valeria Liew
    Thumbnail webinar replay Self-Driving Tableting DataFactory

    Self-driving tableting DataFactory

    Webinar Replays - 07/12/2023 - by Daniel Markl, Bruno Leclercq
    "Self-driving tableting DataFactory"- with guest speaker Daniel Markl, reader at the University of Strathclyde and Associate Director at the CMAC Center for Continuous Manufacturing and Advanced CrystallisationTraditional methods of developing …
    Extended Dwell Flat (XDF) tooling at IHolland

    Timing is key in tabletting

    White Papers - 29/11/2023 -
    Why you need to get your timing right to make better tabletsNeed to mass-produce tablets with quality solid dosage in a quick and cost-effective way? The time that a formulation …
    Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

    Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

    Papers - 11/11/2023 - by Hassana Hsein, Charbel Madi, Vincent Mazel, Pierre Tchoreloff, Virginie Busignies
    The preferred method for enhancing the stability and storage conditions of biopharmaceutical products is freeze-drying. Typically, these freeze-dried products are designed for administration via the parenteral route. However, many parenterally …
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    Effects of Tableting Process Parameters and Powder Lubrication Levels on Tablet Surface Temperature and Moisture Content

    Papers - 08/11/2023 - by Komlan Koumbogle, Ryan Gosselin, François Gitzhofer, Nicolas Abatzoglou
    The occurrence of punch sticking poses a recurrent challenge in the pharmaceutical tablet manufacturing process. The moisture content of the powder plays a crucial role in the development of sticking; …
    Application of Response Surface Methodology to Improve the Tableting Properties of Poorly Compactable and High-Drug-Loading Canagliflozin Using Nano-Sized Colloidal Silica

    Application of Response Surface Methodology to Improve the Tableting Properties of Poorly Compactable and High-Drug-Loading Canagliflozin Using Nano-Sized Colloidal Silica

    Papers - 29/10/2023 - by Majed Alrobaian, Ahmed Alalaiwe, Ziyad S. Almalki, Mohamed H. Fayed
    Creating a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with challenging flow and compaction properties at a high API load poses a considerable challenge. This study …
    Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets

    Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets

    Papers - 26/09/2023 - by Daniel Puckhaber, Arno Kwade, Jan Henrik Finke
    Tablets are frequently manufactured by incorporating particulate lubricants internally, a practice that is recognized for its potential to diminish the mechanical strength of the tablets. This decline is attributed to …
    Effect of drug loading and relative humidity on the mechanical properties and tableting performance of Celecoxib–PVP/VA 64 amorphous solid dispersions

    Effect of drug loading and relative humidity on the mechanical properties and tableting performance of Celecoxib–PVP/VA 64 amorphous solid dispersions

    Papers - 25/09/2023 - by Frederick Osei-Yeboah, Changquan Calvin Sun
    The mechanical characteristics of amorphous solid dispersions (ASDs) based on polymers are susceptible to alterations in relative humidity (RH) conditions. This study aims to elucidate the influence of RH on …
    Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (Echinochloa esculenta) Starch

    Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (Echinochloa esculenta) Starch

    Papers - 22/08/2023 - by Pankaj Bhatt, Vipin Kumar, Harsh Rastogi, Mayank Kumar Malik, Raghav Dixit, Sakshi Garg, Garima Kapoor, Suruchi Singh
    The functional and tableting characteristics of barnyard millet starch (Echinochloa esculenta) were examined in its native (alkali-treated) and chemically modified (phosphorylated) forms. The grains underwent pulverization, soaking, and grinding before …
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    Investigating compressibility descriptors for binary mixtures of different deformation behavior

    Papers - 15/06/2023 - by Sabrina Berkenkemper, Stefan Klinken, Peter Kleinebudde
    Tablets remain one of the most crucial dosage forms, and a key objective in the development of these forms is predicting their tableting behavior. The endeavor to save resources and …
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    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Papers - 05/04/2023 - by Pauline H.M. Janssen, Sara Fathollahi, Bram Bekaert, Dirk Vanderroost, Timo Roelofs, Valerie Vanhoorne, Chris Vervaet, Bastiaan H.J. Dickhoff
    This paper demonstrates the influence of excipient properties on both process parameters and the ultimate tablet properties in a fully integrated continuous direct compression line. The blend properties of low-dose …
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    A compactibility-based lubricant dispersion model describing the effect of formulation and paddle speed

    Papers - 25/11/2022 - by Daniel Puckhaber, Ann Kathrin Schomberg, Arno Kwade, Jan Henrik Finke
    In rotary tablet presses, the entry of powder into the dies is commonly facilitated by a paddle feeder. In formulations with internal lubrication, the shear forces generated by paddle rotation …
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    The Overview of Oral Solid Dosage Forms and Different Excipients Used for Solid Dosage Formulation

    Papers - 24/08/2022 - by Ms. Kiran Rameshbhai Dudhat
    In the development of pharmaceutical dosage forms, the choice of excipients plays a pivotal role in both preformulation and formulation research. The physical, mechanical, and chemical attributes of excipients exert …
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    Influence of the drug deformation behaviour on the predictability of compressibility and compactibility of binary mixtures

    Papers - 17/08/2022 - by Isabell Wünsch, Jan Henrik Finke, Edgar John, Michael Juhnke, Arno Kwade
    Numerous studies have sought to understand the predictability of compressibility and compactibility in tablet formulations by examining the behavior of individual materials. However, the complexity of the powder compaction process …