Scientific papers
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Replacing batch wet granulation with a continuous, solvent-free process using a twin-screw melt extruder is becoming increasingly popular. Although PEG 8000 is a widely used excipient for melt granulation, its impact on the mechanical properties of tablets has not been thoroughly studied. To address this, a blend of microcrystalline cellulose (MCC) and anhydrous calcium phosphate (CaHPO4) was selected for granulation due to its poor flowability.
The study's objective was to evaluate the influence of PEG 8000 particle size and melt granulation temperature on the characteristics of the MCC-CaHPO4 granules and their tablet formulations, as well as to compare the mechanical properties of direct-compressed (DC) and melt-granulated MCC-CaHPO4 tablets.
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