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High-dose modified release formulation-image

High-dose modified-release formulation of a poorly soluble drug via twin-screw melt coating and granulation

Newsfeeds - 17/02/2025 -
Favipiravir, an antiviral drug for COVID-19 with poor water solubility, is formulated using a low-cost melt coating and granulation method. High-dose tablets (600 mg and 800 mg) with desired release …
Unveiling Swelling and Erosion Dynamics: Early Development Screening of Mirabegron Extended Release Tablets

Unveiling swelling and erosion dynamics: early development screening of mirabegron extended release tablets

Papers - 27/11/2024 - by Ana S. Sousa, J. Serra, C. Estevens, R. Costa, António J. Ribeiro
The development of extended-release (ER) matrices has been widely studied, yet identifying the optimal drug release mechanism to achieve target release profiles remains a resource-intensive challenge in early formulation stages. …
Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible

Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled release excipient

Newsfeeds - 28/08/2024 -
One of the most common forms of controlled release technology for oral drug delivery involves dispersing an active ingredient in a hydrophilic matrix-forming polymer like hydroxypropyl methylcellulose (HPMC), which is …
Tablet_TabInTab_5

How To achieve different release profiles and select excipients for formulation development of modified release oral solid dosage forms

Newsfeeds - 10/07/2024 -
Modified release oral solid dosage forms (MROSD) are specialized formulations that enable drug release over a defined period or at specific GI tract locations, improving patient adherence and reducing side …
Tablet_Minitablet_vs_tablet_1

Development of mini-tablet and multi-unit pellet systems (MUPs)

Newsfeeds - 24/05/2024 -
The text discusses the development and benefits of Mini-Tablet and Multi-Unit Pellet Systems (MUPS) in oral drug delivery. These advanced dosage forms offer controlled and sustained release profiles, achieved through …
New Hydrophilic Matrix Tablets for the Controlled Released of Chlorzoxazone

New hydrophilic matrix tablets for the controlled released of chlorzoxazone

Papers - 09/05/2024 - by Andreea Creteanu, Gabriela Lisa, Cornelia Vasile, Maria-Cristina Popescu, Daniela Pamfil, Claudiu N. Lungu, Alina Diana Panainte, Gladiola Tantaru
The controlled release of active ingredients like chlorzoxazone from matrix tablets, utilizing Kollidon®SR and chitosan, relies on both the drug's solubility in the dissolution medium and the composition of the …
image twin screw granulation process

A QbD guided development of a Twin-Screw Granulation process

Newsfeeds - 12/03/2024 -
The text discusses dry granulation techniques in the pharmaceutical industry, focusing on roller compaction and slugging, highlighting their limitations such as inferior tablet strength and reduced yield due to fine …
White powder heap

MEGGLE highlights role of excipient properties in alcohol-induced dose dumping AIDD

Newsfeeds - 01/03/2024 -
The white paper from MEGGLE emphasizes the significance of excipients in addressing alcohol-induced dose dumping (AIDD) in modified-release tablet formulations. AIDD occurs when drugs prematurely release into the bloodstream due …
Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters

Studying the API distribution of controlled release formulations produced via continuous twin-screw wet granulation: influence of matrix former, filler and process parameters

Papers - 28/02/2024 - by Phaedra Denduyver, Chris Vervaet, Valérie Vanhoorne
Hydroxypropyl methylcellulose (HPMC) stands out as the favored hydrophilic matrix former in the production of controlled release formulations via continuous twin-screw wet granulation. However, previous observations have highlighted a challenge: …
Tablet_Multilayer_15_HD.original

Retrospective analysis of the biopharmaceutics characteristics of solid oral Modified-Release drug products

Newsfeeds - 20/02/2024 -
This retrospective study, spanning from 2001 to 2021, examined submissions approved by the US Food and Drug Administration (FDA) for Modified Release (MR) orally administered drugs [Extended-Release (ER) and Delayed-Release …
Developmental strategy for swellable/erodible matrix tablet of mirabegron: quality by design approach with various geometric properties and pharmacokinetic evaluation

Developmental strategy for swellable/erodible matrix tablet of mirabegron: quality by design approach with various geometric properties and pharmacokinetic evaluation

Papers - 21/11/2023 - by Ji Yeon Kim, Tae Hwan Kim, Eunbin Kim, Du Hyung Choi
Objective: This study aimed to devise a developmental strategy for matrix tablets containing mirabegron, incorporating a quality by design approach that considers geometric properties such as gel strength, erosion rate, …
no-image

Evaluation of in-die compression data for a deeper understanding of altered excipient properties upon temperature rise

Papers - 28/03/2023 - by Hanna Dorothea Grumann, Stefan Klinken, Peter Kleinebudde
The thermodynamic analysis of tablet formation involves assessing both thermal and mechanical aspects during compression. This study aimed to examine variations in force–displacement data resulting from temperature increases, serving as …
Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading

Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading

Papers - 01/12/2022 - by Aseel Samaro, Maarten Vergaelen, Martin Purino, Ali Tigrine, Victor R. de la Rosa, Niloofar Moazami Goudarzi, Matthieu N. Boone, Valérie Vanhoorne, Richard Hoogenboom, Chris Vervaet
Achieving sustained release of highly dosed active pharmaceutical ingredients (APIs) from a matrix tablet poses a significant challenge. To tackle this issue, this study assessed the efficacy of thermoplastic poly(2-alkyl-2-oxazoline)s …
Development of an amorphous based sustained release system for apremilast a selective phosphodiesterase 4 (PDE4) inhibitor

Development of an amorphous based sustained release system for apremilast a selective phosphodiesterase 4 (PDE4) inhibitor

Papers - 05/03/2022 - by Qiangnan Zhang, Thomas Durig, Benjamin Blass, Reza Fassihi
Apremilast, a selective PDE4 inhibitor approved for various inflammatory disorders, is categorized as a BCS-IV drug and exists in seven polymorphic forms. This study outlines the creation of a sustained-release …
Starch-based controlled release matrix tablets: impact of the type of starch

Starch-based controlled release matrix tablets: impact of the type of starch

Papers - 20/10/2020 - by D. Elgaied-Lamouchi, N. Descamps, P. Lefevre, I. Rambur, J.-Y. Pierquin, F. Siepmann, J. Siepmann, S. Muschert
Various starch types were employed in the formulation of controlled release tablets containing diprophylline through direct compression. The study explored the influence of starch's natural origin, potential chemical modifications (such …
Robustness of controlled release tablets based on a cross-linked pregelatinized potato starch matrix

Robustness of controlled release tablets based on a cross-linked pregelatinized potato starch matrix

Papers - 01/07/2020 - by D. Elgaied-Lamouchi, N. Descamps, P. Lefèvre, A. R. Mackin-Mohamour, C. Neut, F. Siepmann, Juergen Siepmann, S. Muschert
The objective of this research was to assess the viability of utilizing cross-linked pregelatinized potato starch (marketed as PREGEFLO ® PI10) as a matrix former for controlled release tablets. Various …
A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets

A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets

Papers - 01/01/2020 - by Tze Ning Hiew, Yu Harn Tian, Huei Ming Tan, Paul Wan Sia Heng
The potential harm to the drug diffusion coat barrier of controlled-release pellets due to compaction force during the preparation of multiple-unit pellet system tablets is a significant concern. Prior research …
no-image

STYL’One Evolution / Industrial rotary press correlation study on a tab-in-tab dosage form

Bulletins - 01/02/2018 - by Aline Moulin
These case studies were presented by SKYEPHARMA during CSF Cambridge 2018 to highlight the development of multilayer and tab-in-tab dosage forms on STYL’One Evo while saving time and cost during …
Amorphous-based controlled-release gliclazide matrix system

Amorphous-based controlled-release gliclazide matrix system

Papers - 01/07/2017 - by Zheng Lu, Yonglai Yang, Rae-Ann Covington, Yunxia Bi, Thomas Dürig, Reza Fassihi
The objective of this study was to create a hydrophilic oral controlled release system (CRS) utilizing the amorphous form of gliclazide, a BCS class II compound listed in the WHO …
no-image

Novel polyurethane matrix systems reveal a particular sustained release behavior studied by imaging and computational modeling

Papers - 01/07/2017 - by María Dolores Campiñez, Isidoro Caraballo, Maxim Puchkov, Martin Kuentz
The objective of this study was to enhance the comprehension of the drug-release mechanism from sustained release matrices utilizing two recently developed polyurethanes. A novel in silico formulation tool based …