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    Analysis of the impact of material properties on tabletability by principal component analysis and partial least squares regression

    Analysis of the impact of material properties on tabletability by principal component analysis and partial least squares regression

    Papers - 21/06/2024 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    In this study, principal component analysis (PCA) and partial least squares regression (PLS) were used together to identify the key material descriptors influencing tabletability in direct compression and roller compaction. …
    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Papers - 05/04/2023 - by Pauline H.M. Janssen, Sara Fathollahi, Bram Bekaert, Dirk Vanderroost, Timo Roelofs, Valerie Vanhoorne, Chris Vervaet, Bastiaan H.J. Dickhoff
    This paper demonstrates the influence of excipient properties on both process parameters and the ultimate tablet properties in a fully integrated continuous direct compression line. The blend properties of low-dose …
    Multivariate data analysis to evaluate commonly used compression descriptors

    Multivariate data analysis to evaluate commonly used compression descriptors

    Papers - 27/03/2023 - by Sabrina Berkenkemper, Stefan Klinken, Peter Kleinebudde
    Numerous studies have delved into material behavior through compression analyses, with a particular emphasis on compressibility, compactibility, and tabletability. In this study, an extensive multivariate data analysis was conducted using …
    An approach for predicting the true density of powders based on in-die compression data

    An approach for predicting the true density of powders based on in-die compression data

    Papers - 21/03/2023 - by Ramy N. Elsergany, Gerrit Vreeman, Changquan Calvin Sun
    Helium pycnometry, a widely employed technique for assessing the true density of powders, is susceptible to the impact of volatiles released during measurement. This susceptibility can result in an overestimation …
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    Direct tableting on a continuous manufacturing line—impact of mixing parameters, material densities, and drug load on subsequent process parameters and tablet quality

    Papers - 17/02/2023 - by Marius J. Kreiser, Christoph Wabel, Karl G. Wagner
    In recent years, continuous manufacturing (CM) of solid oral dosage forms has gained significant attention, emerging as a leading technology in the pharmaceutical industry. A model has been formulated based …
    Evaluation of alternative methods to derive particle density from compression data

    Evaluation of alternative methods to derive particle density from compression data

    Papers - 03/01/2023 - by Sabrina Berkenkemper, Peter Kleinebudde
    Determining particle density is a crucial aspect of material characterization, particularly in compression analyses. Helium pycnometry, the most commonly used method, has faced criticism for various reasons, with a notable …
    Challenges and solutions in drug product process development from a material science perspective

    Challenges and solutions in drug product process development from a material science perspective

    Papers - 07/04/2022 - by Antonios Fytopoulos, Rohit Ramachandran, Panos M. Pardalos, Fanny Stauffer, Pierre-François Chavez, Julie Fahier, Corentin Larcy, Mehrdad Pasha, Gabrielle Pilcer
    While it is widely acknowledged that comprehending the impact of material attributes on drug product processes is crucial for designing resilient products and processes, the systematic identification of critical process …
    Investigating key properties of model excipients and binary powder blends using ultrasonic in-die measurements on a compaction simulator

    Investigating key properties of model excipients and binary powder blends using ultrasonic in-die measurements on a compaction simulator

    Papers - 05/02/2022 - by Melinda Kern, Thomas Riedel, Jörg Breitkreutz
    This study examined the Kilian Inline Measurement System (KIM), a recently introduced tool enabling ultrasonic measurements during powder compaction. Three pharmaceutical excipients with diverse properties and particle sizes were investigated, …
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    Material characterization with a V-shape compression profile on STYL'One Nano

    Bulletins - 01/08/2021 - by Sixtine Caquant, Quentin Boulay
    In the early stages of drug development, APIs are often available in limited amount. However, scientists have to foresee the impact of compaction parameters on tablet attributes. In fact, tablet …
    Novel ultrasonic in-die measurements during powder compression at production relevant speed

    Novel ultrasonic in-die measurements during powder compression at production relevant speed

    Papers - 01/11/2019 - by Veronika Hagelstein, Benjamin Frindt, Mathias Hucke, Jörg Pieper, Jens Carstens, Robert F. Lammens, Karl G. Wagner
    A groundbreaking ultrasonic instrumentation has been successfully integrated into a compaction simulator. This setup utilized a through-transmission configuration with alternating longitudinal and transverse transducers positioned inside Euro-D-modified punches. The text …
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    Characterization guidelines

    Bulletins - 05/05/2017 -
    This document describes some best practices in characterizing pharmaceutical powder (API / Excipients). It reviews the following topics: Tabletability / Manufacturability Profiles Ejection Force / Ejection Stress Transmission Ratio Strain …
    Assessing materials' tablet compaction properties using the Drucker–Prager Cap model

    Assessing materials' tablet compaction properties using the Drucker–Prager Cap model

    Papers - 01/11/2014 - by Keirnan LaMarche, David Buckley, Ruiling Hartley, Feng Qian, Sherif Badawy
    Tablet compaction stands as the predominant method for manufacturing solid dosage forms within the pharmaceutical industry. Despite its widespread application, many commonly employed approaches for assessing the compaction behavior of …