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Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

Understanding the roles of excipients in moisture management in solid dosage forms

Papers - 22/04/2024 - by Natalia Veronica, Paul W. S. Heng, Celine V. Liew
"Excipients are widely present in pharmaceutical products, often playing a crucial role in maintaining product quality. In the case of products containing drugs sensitive to moisture, the presence of moisture …
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Effects of tableting process parameters and powder lubrication levels on tablet surface temperature and moisture content

Papers - 08/11/2023 - by Komlan Koumbogle, Ryan Gosselin, François Gitzhofer, Nicolas Abatzoglou
The occurrence of punch sticking poses a recurrent challenge in the pharmaceutical tablet manufacturing process. The moisture content of the powder plays a crucial role in the development of sticking; …
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Effect of process parameters, protectants and carrier materials on the survival of yeast cells during fluidized bed granulation for tableting

Papers - 09/03/2023 - by Karl Vorländer, Lukas Bahlmann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
This study focuses on the drying of Saccharomyces cerevisiae, a yeast variety that includes the probiotic Saccharomyces boulardii. Ensuring microbial viability is crucial for effective dosage forms, especially for probiotics …
Alginate ester: New moisture-scavenging excipients for direct compressible pharmaceutical tableting

Alginate ester: new moisture-scavenging excipients for direct compressible pharmaceutical tableting

Papers - 01/12/2022 - by Noelia M. Sanchez-Ballester, Philippe Trens, Jean-Christophe Rossi, Ian Soulairol
This study aims to assess methyl ester alginates and alginic acid (AA) as moisture-scavenging excipients for formulating aspirin tablets through direct compression. The tablets underwent storage under accelerated conditions (40 …
Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of Acetylsalicylic Acid Tablets

Impact of amylose-amylopectin ratio of starches on the mechanical strength and stability of acetylsalicylic acid tablets

Papers - 20/04/2022 - by Natalia Veronica, Celine Valeria Liew, Paul Wan Sia Heng
The interaction of starch with moisture is primarily influenced by its two key components, amylose and amylopectin. This investigation delved into the moisture sorption properties of starches with varying amylose-amylopectin …
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Insights into the moisture scavenging properties of different types of starch in tablets containing a moisture-sensitive drug

Papers - 06/11/2020 - by Natalia Veronica, Tze Ning Hiew, Celine Valeria Liew, Paul Wan Sia Heng
Starch is a widely utilized excipient in the pharmaceutical industry, yet limited information exists regarding the impact of its moisture scavenging properties in safeguarding moisture-sensitive drugs. The interplay between starch …
High-molecular-weight hypromellose from three different suppliers: effects of compression speed, tableting equipment, and moisture on the compaction

High-molecular-weight hypromellose from three different suppliers: effects of compression speed, tableting equipment, and moisture on the compaction

Papers - 01/07/2020 - by Peter Grdešič, Amrit Paudel, Ilija German Ilić
The increasing significance of higher tableting speeds in the pharmaceutical industry prompts a need for comprehensive studies on the mechanical properties of hypromellose. Surprisingly, there is a lack of recent …
Insights on the role of excipients and tablet matrix porosity on aspirin stability

Insights on the role of excipients and tablet matrix porosity on aspirin stability

Papers - 01/04/2020 - by Natalia Veronica, Celine Valeria Liew, Paul Wan Sia Heng
The interaction between excipients and moisture can significantly impact product stability. This study aimed to investigate the influence of incorporating excipients with varying moisture interactions into formulations containing a moisture-sensitive …
Moisture adsorption and desorption properties of colloidal silicon dioxide and its impact on layer adhesion of a bilayer tablet formulation.

Moisture adsorption and desorption properties of colloidal silicon dioxide and its impact on layer adhesion of a bilayer tablet formulation.

Papers - 01/03/2014 - by Jennifer Wang, David Trinkle, George Derbin, Kyle Martin, Shasad Sharif, Divyakant Desai
A fixed-dose combination tablet formulation of drugs Y and Z was developed using a bilayer tablet approach. Layer I, containing 250 mg of Drug Y, was produced through dry granulation, …