Close search
Scientific papers

Scientific papers

Favorite Articles

    Tags

    Categories

    Authors

    13 results
    Date
    Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

    Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

    Papers - 13/03/2024 - by Donald J. Clancy, Gulenay Guner, Sayantan Chattoraj, Helen Yao, M. Connor Faith, Zahra Salahshoor, Kailey N. Martin, Ecevit Bilgili
    The objective of this study was to create a practical semi-mechanistic modeling framework for forecasting particle size changes during the wet bead milling of pharmaceutical nanosuspensions across various process conditions …
    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Papers - 07/01/2024 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Bindhumadhavan Gururajan, Supriya Rane, Arno Kwade
    Most tablets produced include lubricants to minimize friction during ejection. However, in the case of plastically deforming materials such as microcrystalline cellulose (MCC), internal incorporation of lubricants is known to …
    Investigating the heat sensitivity of frequently used excipients with varying particle sizes

    Investigating the heat sensitivity of frequently used excipients with varying particle sizes

    Papers - 01/11/2023 - by Hanna Dorothea Grumann, Peter Kleinebudde
    In the course of tablet manufacturing, an elevation in production temperature can result in changes to tablet characteristics. This study explores the impact of the initial particle size on the …
    no-image

    Downstream processing of amorphous solid dispersions into orodispersible tablets

    Papers - 25/01/2023 - by Marcel Kokott, Stefan Klinken, Jörg Breitkreutz, Raphael Wiedey
    The development of patient-friendly oral solid dosage forms for amorphous solid dispersions (ASDs) remains a challenging task. Orodispersible tablets (ODTs) present a promising alternative to enhance patient compliance. Two distinct …
    no-image

    Varied Bulk Powder Properties of Micro-Sized API within Size Specifications as a Result of Particle Engineering Methods

    Papers - 08/09/2022 - by Zijian Wang, Marina Solomos, Stephanus Axnanda, Chienhung Chen, Margaret Figus, Luke Schenck, Changquan Calvin Sun
    Micronized particles are commonly employed to enhance content uniformity (CU), dissolution performance, and the bioavailability of active pharmaceutical ingredients (API). Various particle engineering methods have been developed to produce micron-sized …
    no-image

    The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets: Potentials and comparison to common physical methods

    Papers - 10/07/2021 - by A.K. Schomberg, A. Diener, I. Wünsch, J.H. Finke, A. Kwade
    In this study, X-ray microtomography (XMT) was employed to investigate the microstructure of tablets. The objective was to obtain insights into their microstructure, facilitating a more profound interpretation of tablet …
    no-image

    Effect of excipient particle size distribution variability on compact tensile strength; and its in-line prediction by force-displacement and force-time profiling

    Papers - 12/01/2021 - by Wee Beng Lee, Effendi Widjaja, Paul Wan Sia Heng, Lai Wah Chan
    Background: The sensitivity of direct compression to the variability in particle size distribution (PSD) of pharmaceutical-grade excipients remains insufficiently explored. Additionally, the utilization of a force sensor as a process …
    no-image

    Influence of Formulation Parameters on Redispersibility of Naproxen Nanoparticles from Granules Produced in a Fluidized Bed Process

    Papers - 16/04/2020 - by Martin Wewers, Stefan Czyz, Jan Henrik Finke, Edgar John, Bernard Van Eerdenbrugh, Michael Juhnke, Heike Bunjes, Arno Kwade
    Reducing the particle size of active pharmaceutical ingredients is an efficient strategy for addressing challenges related to poor aqueous solubility. To enhance stability and patient convenience, nanosuspensions are often converted …
    no-image

    Understanding the Factors That Control the Quality of Mini-Tablet Compression: Flow, Particle Size, and Tooling Dimension

    Papers - 01/04/2018 - by Junshu Zhao, David Yin, Jasmine Rowe, Sherif Badawy, Faranak Nikfar, Preetanshu Pandey
    Despite the growing significance of mini-tablets for their advantages in pediatric formulations and modified-release applications, their widespread use is hindered by the limited knowledge of formulation and processing techniques required …
    no-image

    THE IMPACT OF THE ALEXANDERWERK WP120 MILL UPPER MESH SIZE ON THE GRANULE PROPERTIES OF ALACTOSE/MICROCRYSTALLINE CELLULOSE PLACEBO FORMULATION

    Papers - 01/01/2018 - by Karim Hassan, Marwan ElBagoury, Maryam Kotb
    The continuous evolution of new moisture-sensitive active pharmaceutical ingredients (APIs) has increased the popularity of roller compaction, prompting research into various processing parameters that could optimize roller compactor production. The …
    no-image

    Engineered particles demonstrate improved flow properties at elevated drug loadings for direct compression manufacturing

    Papers - 01/05/2017 - by Andrea N. Trementozzi, Cheuk-Yui Leung, Frederick Osei-Yeboah, Erwin Irdam, Yiqing Lin, J. Michael MacPhee, Pierre Boulas, Shyam B. Karki, Peter N. Zawaneh
    Optimizing the powder flow and compaction properties is crucial to ensure a reliable tablet manufacturing process. The significance of the flow and compaction properties of the active pharmaceutical ingredient (API) …
    no-image

    Hot-stage microscopy for determination of API fragmentation: comparison with other methods

    Papers - 21/05/2015 - by Michal Šimek, Veronika Grünwaldová, Bohumil Kratochvíl
    While the fragmentation of the active pharmaceutical ingredient (API) is acknowledged in various literature sources, there is currently a lack of suitable analytical tools for its investigation. In this study, …
    no-image

    Roller compaction: Application of an in-gap ribbon porosity calculation for the optimization of downstream granule flow and compactability characteristics

    Papers - 01/06/2010 - by John F. Gamble, Michael Tobyn, Andrew B. Dennis, Trupty Shah
    This paper discusses the utilization of an in-gap ribbon porosity calculation to optimize roller compaction ribbon parameters, aiming to regulate downstream granule and tablet properties in a typical pharmaceutical formulation. …