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    Powder_Explosion_Red_iStock-525212190

    Excipients used for solid dosage: innovations and challenges

    Newsfeeds - 14/08/2024 -
    *Excipients Used for Solid Dosage: Innovations and ChallengesSolid dosage forms are preferred in pharmaceuticals due to their ease of administration, accuracy, and cost-effectiveness. However, their effectiveness depends not just on …
    The Increase in the Plasticity of Microcrystalline Cellulose Spheres’ When Loaded with a Plasticizer

    The increase in the plasticity of microcrystalline cellulose spheres’ when loaded with a plasticizer

    Papers - 16/07/2024 - by Artūrs Paulausks, Tetiana Kolisnyk, Valentyn Mohylyuk
    Compaction pressure can cause undesirable effects in drugs such as solid-state polymorphic transitions, fragmentation, loss of coated pellet integrity, and reduced viability and vitality of microorganisms. To mitigate these effects, …
    Laboratory network - image - strategies to formulate poorly soluble api

    4 strategies to formulate poorly soluble APIs

    Newsfeeds - 01/03/2024 -
    The text discusses strategies employed by researchers and pharmaceutical scientists to address the challenge of poor solubility in APIs. It outlines four main techniques: lipid-based formulations, amorphous solid dispersions, nanotechnology, …
    The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

    The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

    Papers - 22/02/2024 - by Dongyue Yu, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method proves effective in enhancing the solubility, dissolution, and bioavailability of poorly water-soluble medications. However, these forms are prone to transitioning into more thermodynamically stable, …
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    Novel drug-loaded paper tablets for improved oral drug delivery

    Papers - 01/02/2023 - by Ayat Abdelkader Mohamed Aboelela
    The preferred route for drug administration is oral, and tablets stand out as the most prominent oral dosage form due to their advantages in dose precision, stability, simplicity, cost-effectiveness, and …
    Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools

    Itraconazole amorphous solid dispersion tablets: formulation and compaction process optimization using Quality by Design principles and tools

    Papers - 07/11/2022 - by Hetvi Triboandas, Kendal Pitt, Mariana Bezerra, Delphine Ach-Hubert, Walkiria Schlindwein
    BCS Class II drugs, exemplified by itraconazole (ITZ), are characterized by poor solubility (1–4 ng/mL), necessitating solubility enhancement. Consequently, amorphous solid dispersions (ASDs) of ITZ and Kollidon® VA64 (KOL) were …
    Influence of formulation parameters on redispersibility of naproxen nanoparticles from granules produced in a fluidized bed process

    Influence of formulation parameters on redispersibility of naproxen nanoparticles from granules produced in a fluidized bed process

    Papers - 16/04/2020 - by Martin Wewers, Stefan Czyz, Jan Henrik Finke, Edgar John, Bernard Van Eerdenbrugh, Michael Juhnke, Heike Bunjes, Arno Kwade
    Reducing the particle size of active pharmaceutical ingredients is an efficient strategy for addressing challenges related to poor aqueous solubility. To enhance stability and patient convenience, nanosuspensions are often converted …
    Modeling of disintegration and dissolution behavior of mefenamic acid formulation using numeric solution of Noyes-Whitney equation with cellular automata on microtomographic and algorithmically generated surfaces

    Modeling of disintegration and dissolution behavior of mefenamic acid formulation using numeric solution of Noyes-Whitney equation with cellular automata on microtomographic and algorithmically generated surfaces

    Papers - 03/12/2018 - by Reiji Yokoyama, Go Kimura, Christian Schlepütz, Jörg Huwyler, Maxim Puchkov
    Manufacturing parameters can significantly influence the dissolution and disintegration of solid dosage forms. In alignment with Process Analytical Technology (PAT) and Quality by Design (QbD) approaches, computer-based technologies offer the …
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    Wetting effects versus ion pairs diffusivity: Interactions of anionic surfactants with highly soluble cationic drugs and its impact on tablet dissolution

    Papers - 01/07/2015 - by Divyakant Desai, Benjamin Wong, Yande Huang, Qingmei Ye, Hang Guo, Ming Huang, Peter Timmins
    A study was undertaken to gain a mechanistic understanding of the dissolution of metformin hydrochloride, a highly soluble cationic drug, in the presence of anionic surfactants known as sodium alkyl …
    Spray-dried solid dispersions of nifedipine and vinylcaprolactam/vinylacetate/PEG6000 for compacted oral formulations

    Spray-dried solid dispersions of nifedipine and vinylcaprolactam/vinylacetate/PEG6000 for compacted oral formulations

    Papers - 15/03/2015 - by Ian Soulairol, Nicolas Tarlier, Bernard Bataille, Thomas Cacciaguerra, Tahmer Sharkawi
    The objective of this study was to explore an alternative processing technology for a novel polymeric solubilizer primarily employed in hot melt extrusion. Poorly soluble nifedipine was co-processed through spray-drying …
    Surfactant-mediated dissolution of metformin hydrochloride tablets: wetting effects versus ion pairs diffusivity

    Surfactant-mediated dissolution of metformin hydrochloride tablets: wetting effects versus ion pairs diffusivity

    Papers - 01/03/2014 - by Divyakant Desai, Benjamin Wong, Yande Huang, Qingmei Ye, Dan Tang, Hang Guo, Ming Huang, Peter Timmins
    The aqueous solubility of metformin (pKa: 2.8 and 11.5) within the pH range of 1.2–6.8 is 300 mg/mL, suggesting that the dissolution of metformin hydrochloride tablets should exhibit pH independence. …