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    White-Powder-Petri-Dishes-2

    Spray drying for a sticky API (low glass transition temperature)

    Newsfeeds - 16/09/2024 -
    It is widely recognized that 40% of New Chemical Entities (NCEs) in the pharmaceutical industry exhibit poor solubility, resulting in inadequate bioavailability. Spray drying has emerged as a promising particle …
    Image Recent Innovatioins and enhancements to pharmaceutial spray drying

    Recent innovations and enhancements to pharmaceutical spray drying

    Newsfeeds - 12/06/2024 -
    The text discusses the use of spray drying in the pharmaceutical industry for enhancing particle engineering and bioavailability, with a focus on Lonza's expertise and advancements.Key points include:*Spray Drying Process: …
    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Papers - 04/06/2024 - by Allisson N. DuRoss, Kendall R. Pearson, Mark E. Waller, Hannah E. Worrest
    Problem Statement • Dry granulation (DG) demonstration batches consume large amounts of material and time • Spray dried intermediate (SDI) based tablets commonly require upstream dry granulation • Previous workflows …
    Image Rapid And Material-Sparing Feasibility Screening For Hot Melt Extrusion

    Rapid and material-sparing feasibility screening for hot melt extrusion

    Newsfeeds - 05/04/2024 -
    Amorphous solid dispersions (ASD) present a solution for enhancing the bioavailability of crystalline APIs that are otherwise poorly soluble. Two primary methods for manufacturing ASDs are spray drying and hot …
    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: compaction, dissolution, and physical stability

    Papers - 25/01/2024 - by Dongyue Yu, Haichen Nie, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method is a well-established approach to enhance the solubility and bioavailability of poorly soluble drugs. Although a significant number of ASD products are in tablet …
    ThermoFisher - Solving for Solubility a scale-up strategy for spray-dried dispersions

    Solving for solubility: a scale-up strategy for spray dried dispersion

    Newsfeeds - 12/01/2024 -
    Webinar replay by ThermoFisherSpray drying provides a remedy for formulation obstacles in improving the bioavailability of poorly soluble APIs. While the procedure is thoroughly comprehended, achieving successful spray drying demands …
    The Development of Oral Solid Dosage Forms Using the Direct-Compression Tableting of Spray-Dried Bacteriophages Suitable for Targeted Delivery and Controlled Release

    The development of oral solid dosage forms using the direct-compression tableting of spray-dried bacteriophages suitable for targeted delivery and controlled release

    Papers - 03/11/2023 - by Zahra Rezaie Yazdi, Mark C. Leaper, Danish J. Malik
    This study tackles the challenge of creating an affordable, patient-friendly alternative to antibiotics for gastrointestinal applications, utilizing bacteriophages. The research investigates the possibility of producing an enteric solid dosage form …
    Process and formulation parameters influencing the survival of Saccharomyces cerevisiae during spray drying and tableting

    Process and formulation parameters influencing the survival of Saccharomyces cerevisiae during spray drying and tableting

    Papers - 05/06/2023 - by Karl Vorländer, Paula Pramann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    Probiotic microorganisms offer health benefits when administered in a viable form and at adequate doses. Dry dosage forms, particularly tablets, are preferred due to their numerous advantages. However, it is …
    Enhancing tabletability of high-dose tablets by tailoring properties of spray-dried insulin particles

    Enhancing tabletability of high-dose tablets by tailoring properties of spray-dried insulin particles

    Papers - 25/01/2023 - by Mahdieh Dagina Pedersen, Andrew Megarry, Kaisa Naelapää, Thomas Rades, Jenni Pessi
    The oral administration of proteins and peptides is an appealing option for dosing due to its high patient compliance. However, formulating these macromolecules for oral delivery often involves incorporating permeation …
    Development of an amorphous based sustained release system for apremilast a selective phosphodiesterase 4 (PDE4) inhibitor

    Development of an amorphous based sustained release system for apremilast a selective phosphodiesterase 4 (PDE4) inhibitor

    Papers - 05/03/2022 - by Qiangnan Zhang, Thomas Durig, Benjamin Blass, Reza Fassihi
    Apremilast, a selective PDE4 inhibitor approved for various inflammatory disorders, is categorized as a BCS-IV drug and exists in seven polymorphic forms. This study outlines the creation of a sustained-release …
    The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of itraconazole-HPMCAS spray dried dispersions

    The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of itraconazole-HPMCAS spray dried dispersions

    Papers - 16/09/2020 - by Moshe Honick, Sharmila Das, Stephen W. Hoag, Francis X. Muller, Alaadin Alayoubi, Xin Feng, Ahmed Zidan, Muhammad Ashraf, James E. Polli
    Spray-dried dispersions (SDDs) hold considerable potential in enhancing the oral bioavailability of drugs with limited water solubility. Nevertheless, SDDs often exhibit material attributes, such as small particle size, low bulk …
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    Itraconazole-HPMCAS amorphous spray dried dispersions: composition and process factors impacting performance

    Papers - 01/01/2019 - by Moshe Avraham Honick
    Despite their potential to enhance the oral bioavailability of poorly water-soluble drugs, spray-dried dispersions (SDDs) present formulation challenges due to their specific properties. This dissertation aimed to clarify the composition …
    Influence of spray nozzle aperture during high shear wet granulation on granule properties and its compression attributes

    Influence of spray nozzle aperture during high shear wet granulation on granule properties and its compression attributes

    Papers - 01/12/2018 - by Natalia Veronica, Hui Ping Goh, Christina Yong Xin Kang, Celine Valeria Liew, Paul Wan Sia Heng
    The distribution of granulating liquid is acknowledged to influence the high shear wet granulation process, but the impact of spray nozzle attributes remains unclear. While a spray nozzle can achieve …
    Amorphous-based controlled-release gliclazide matrix system

    Amorphous-based controlled-release gliclazide matrix system

    Papers - 01/07/2017 - by Zheng Lu, Yonglai Yang, Rae-Ann Covington, Yunxia Bi, Thomas Dürig, Reza Fassihi
    The objective of this study was to create a hydrophilic oral controlled release system (CRS) utilizing the amorphous form of gliclazide, a BCS class II compound listed in the WHO …
    Supersaturated controlled release matrix using amorphous dispersions of glipizide

    Supersaturated controlled release matrix using amorphous dispersions of glipizide

    Papers - 01/09/2016 - by Zheng Lu, Yonglai Yang, Rae-Ann Covington, Yunxia (Vivian) Bi, Thomas Dürig, Marc A. Ilies, Reza Fassihi
    Spray-dried dispersions (SDDs) of glipizide, a model drug classified as BCS Class II, were created utilizing various hydroxypropyl methylcellulose acetate succinate (HPMCAS) grades and copovidone S-630 as carriers. Analysis through …
    Spray-dried solid dispersions of nifedipine and vinylcaprolactam/vinylacetate/PEG6000 for compacted oral formulations

    Spray-dried solid dispersions of nifedipine and vinylcaprolactam/vinylacetate/PEG6000 for compacted oral formulations

    Papers - 15/03/2015 - by Ian Soulairol, Nicolas Tarlier, Bernard Bataille, Thomas Cacciaguerra, Tahmer Sharkawi
    The objective of this study was to explore an alternative processing technology for a novel polymeric solubilizer primarily employed in hot melt extrusion. Poorly soluble nifedipine was co-processed through spray-drying …