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    Tablet_Multilayer_15_HD.original

    Key considerations in multilayer tableting

    White Papers - 15/06/2021 - by Jean Yves Balfin
    The manufacturing of multilayer tablets may seem to be simple duplications of the basic single-layer compression cycle, but in reality, the process is far more complicated. In this article, KORSCH …
    2021.06.09 - Webinar_uploaded on MSO

    Impact of geometrical process parameters on the tab-in-tab structure

    Webinar Replays - 11/06/2021 - by Léo Picart, Aline Moulin, Bruno Leclercq
    Léo Picart (University of Bordeaux), Aline Moulin (Skyepharma) and Bruno Leclercq (Medelpharm) share on press coated tablets for the control release.
    TPLS as predictive platform for twin-screw wet granulation process and formulation development

    TPLS as predictive platform for twin-screw wet granulation process and formulation development

    Papers - 08/06/2021 - by A. Ryckaert, D. Van Hauwermeiren, J. Dhondt, A. De Man, A. Funke, D. Djuric, C. Vervaet, I. Nopens, T. De Beer
    In recent years, there has been a growing interest in continuous manufacturing techniques, such as twin-screw wet granulation. However, our comprehension of how the combination of raw material properties and …
    Enabling the direct compression of metformin hydrochloride through QESD crystallization

    Enabling the direct compression of metformin hydrochloride through QESD crystallization

    Papers - 01/06/2021 - by Jerome Hansen, Peter Kleinebudde
    Metformin hydrochloride, employed in treating type 2 diabetes, exhibits notable challenges with poor flowability and agglomeration during storage, making direct compression into tablets a hitherto unsuccessful endeavor. A previous study …
    Effects of compaction and storage conditions on stability of intravenous immunoglobulin - implication on developing oral tablets of biologics

    Effects of compaction and storage conditions on stability of intravenous immunoglobulin - implication on developing oral tablets of biologics

    Papers - 26/05/2021 - by Yuwei Lu, Chenguang Wang, Bowen Jiang, Changquan Calvin Sun, Stephen W. Hoag
    Biological products, encompassing therapeutic proteins, vaccines, and cell-based therapeutics, are witnessing rapid growth in the global market. Monoclonal antibodies, in particular, constitute a substantial portion of the biologics market. When …
    Cellulosic dry binders in direct compression and roll compaction - effect of particle size and mechanical properties on tablet performance

    Cellulosic dry binders in direct compression and roll compaction - effect of particle size and mechanical properties on tablet performance

    Papers - 14/05/2021 - by Amol Batra, Ronald Deeter, Michael Kogan, Anthony Sosnowik, Vivian Bi, Daniel Sieber, Christian Muehlenfeld, Tom Dürig
    Dry binders play a critical role in achieving desirable tablet hardness and low friability in both direct compression (DC) and roll compaction/dry granulation (RCDG) processes. Frequently, these dry binders are …
    Does tabletability really improve with decreased diameters of tablet punches

    Does tabletability really improve with decreased diameters of tablet punches

    Papers - 14/05/2021 - by Ard Lura, Jörg Breitkreutz
    In 1989, Pich and Moest patented mini tablets containing 99.5% pancreatin. Their investigations aimed to tablet the same formulation into 10 mm tablets, but this attempt was unsuccessful. In contrast, …
    Enabling the direct compression of metformin hydrochloride through QESD crystallization - Poster

    Enabling the direct compression of metformin hydrochloride through QESD crystallization - Poster

    Papers - 14/05/2021 - by Jerome Hansen, Peter Kleinebudde
    Metformin hydrochloride (MF) is a drug used in the treatment of type 2 diabetes. It is administered orally in the form of tablets with a high drug load. Due to …
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    Characterization and modeling the viscoelasticity on pharmaceutical tablets

    Papers - 12/05/2021 - by Leo Desbois, Vincent Mazel, Pierre Tchoreloff
    Managing the impact of compaction speed on the ultimate properties of tablets poses a significant challenge in scaling up solid dosage forms. The transformation of powder compaction properties concerning compaction …
    Effect of binder type and lubrication method on the binder efficacy for direct compression

    Effect of binder type and lubrication method on the binder efficacy for direct compression

    Papers - 12/05/2021 - by C de Backere, V Vanhoorne, T De Beer, C Vervaet
    1. Introduction : Addition of a binder to a direct compression formulation to increase tablet tensile strength and prevent tablets defects. Internal blending of magnesium stearate (MgSt) is often associated …
    Formation of Delta-Mannitol bu co-spray drying to enhance tabletability of paracetamol-mannitol formulations

    Formation of Delta-Mannitol bu co-spray drying to enhance tabletability of paracetamol-mannitol formulations

    Papers - 12/05/2021 - by E De Pauw, C Vervaet, V Vanhoorne
    Introduction: Mannitol (MAN) serves as a polymorphic excipient (α-, β-, δ-MAN) frequently utilized in tablet formulations. Although delta-mannitol (δ-MAN) exhibits superior compaction behavior, achieving consistent and scalable production poses a …
    Granfiller-D® & Hisorad® as new co-processed excipients for orally disintegrating tablets produced by direct compression

    Granfiller-D® & Hisorad® as new co-processed excipients for orally disintegrating tablets produced by direct compression

    Papers - 12/05/2021 - by M Kokott, T Okabayashi, A Lura, R Wiedey, J Breitkreutz
    Tablets continue to be the predominant oral dosage form, owing to their uncomplicated administration and relatively economical manufacturing. However, a significant drawback is the challenge of swallowing or chewing, particularly …