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Does tabletability really improve with decreased diameters of tablet punches

Papers - 14/05/2021 - by Ard Lura, Jörg Breitkreutz

In 1989, Pich and Moest patented mini tablets containing 99.5% pancreatin. Their investigations aimed to tablet the same formulation into 10 mm tablets, but this attempt was unsuccessful. In contrast, …

Compression profiles of a directly compressible starch using compaction simulation and high-speed tablet press

Papers - 12/05/2021 - by Jessica Tran-Dinh, Manish Rane, Ali Rajabi-Siahboomi, Matthew Roberts, Gökçehan Pürsöken

Starch-based excipients are commonly employed in the creation of solid oral formulations due to their properties as binders, fillers, or disintegrants. Maize starches, chosen for their inert and stable nature …

Direct compression of probiotics: A screening study

Papers - 12/05/2021 - by O Chambin, C Laurent, J Brouzes, B Leclercq, S Muschert

Probiotics show potential as therapeutic options for bowel disorders and diseases. However, these intestinal bacteria are highly susceptible to oxidative degeneration, a process exacerbated by the elevated compression forces typically …

Characterization and modeling the viscoelasticity on pharmaceutical tablets

Papers - 12/05/2021 - by Leo Desbois, Vincent Mazel, Pierre Tchoreloff

Managing the impact of compaction speed on the ultimate properties of tablets poses a significant challenge in scaling up solid dosage forms. The transformation of powder compaction properties concerning compaction …

Granfiller-D® & Hisorad® as new co-processed excipients for orally disintegrating tablets produced by direct compression

Papers - 12/05/2021 - by M Kokott, T Okabayashi, A Lura, R Wiedey, J Breitkreutz

Tablets continue to be the predominant oral dosage form, owing to their uncomplicated administration and relatively economical manufacturing. However, a significant drawback is the challenge of swallowing or chewing, particularly …

Formation of Delta-Mannitol bu co-spray drying to enhance tabletability of paracetamol-mannitol formulations

Papers - 12/05/2021 - by E De Pauw, C Vervaet, V Vanhoorne

Introduction: Mannitol (MAN) serves as a polymorphic excipient (α-, β-, δ-MAN) frequently utilized in tablet formulations. Although delta-mannitol (δ-MAN) exhibits superior compaction behavior, achieving consistent and scalable production poses a …

Effect of binder type and lubrication method on the binder efficacy for direct compression

Papers - 12/05/2021 - by C de Backere, V Vanhoorne, T De Beer, C Vervaet

1. Introduction : Addition of a binder to a direct compression formulation to increase tablet tensile strength and prevent tablets defects. Internal blending of magnesium stearate (MgSt) is often associated …

Critical tools in tableting research: using compaction simulator and Quality by Design (QbD) to evaluate lubricants’ effect in direct compressible formulation

Papers - 11/05/2021 - by Nailla Jiwa, Yildiz Ozalp, Gizem Yegen, Buket Aksu

As widely acknowledged, the product development phase is intricate, demanding a depth of knowledge and substantial time investment. The meticulous selection of excipients, considering their appropriate functionalities and corresponding levels, …

$Dynamic fracture analysis in Brazilian test: application to pharmaceutical tablets$

Dynamic fracture analysis in Brazilian test: application to pharmaceutical tablets

Papers - 10/05/2021 - by B. Croquelois, J. B. Kopp, J. Girardot, P. Tchoreloff, V. Mazel

This paper employs the flattened disk Brazilian test to assess the critical fracture parameter of a pharmaceutical tablet composed of compressed anhydrous lactose powder. In line with prior studies, the …

Material characterization with extended dwell time compression profile on STYL'One Nano

Bulletins - 01/05/2021 - by Quentin Boulay, Sixtine Caquant

During the development of a new drug, active materials are often available in small quantities for cost or process reasons. However, scientists have to understand their deformation behavior to design …

20210421_Webinar_DOE_on_STYL'One_Nano_v3 BL

Design of Experiments (DoE) to better understand tablet formulations

Webinar Replays - 15/04/2021 - by Mariana Bezerra, Bruno Leclercq

Mariana Bezerra (De Montfort University, Leicester UK) tells you more on DoE and the MEDELPHARM Science Lab shows how it can be performed on a STYL'One nano.

Performance evaluation of a novel biosourced co-processed excipient in direct compression and drug release

Papers - 23/03/2021 - by Rihab Benabbas, Noelia M. Sanchez-Ballester, Adrien Aubert, Tahmer Sharkawi, Bernard Bataille, Ian Soulairol

This study highlights the potential utility of a novel co-processed excipient, comprising alginic acid and microcrystalline cellulose (Cop AA-MCC), in the formulation of immediate drug release tablets through direct compression. …

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