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    Process induced transformation (PITs) during tablet manufacturing

    Papers - 09/06/2014 - by Audrey Juban, Régis Cazes, Stéphanie Briançon, Hatem Fessi, François Puel
    Assess the impact of operating conditions, encompassing both process and formulation parameters, on solid phase transitions during direct compression.
    Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface

    Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface

    Papers - 15/05/2014 - by Tanja Stirnimann, Susanna Atria, Joachim Schoelkopf, Patrick A. C. Gane, Rainer Alles, Jörg Huwyler, Maxim Puchkov
    In this study, our objective was to characterize the compressibility and compactibility of a novel pharmaceutical excipient known as functionalized calcium carbonate (FCC). We investigated three different modifications of FCC …
    Surfactant-mediated dissolution of metformin hydrochloride tablets: wetting effects versus ion pairs diffusivity

    Surfactant-mediated dissolution of metformin hydrochloride tablets: wetting effects versus ion pairs diffusivity

    Papers - 01/03/2014 - by Divyakant Desai, Benjamin Wong, Yande Huang, Qingmei Ye, Dan Tang, Hang Guo, Ming Huang, Peter Timmins
    The aqueous solubility of metformin (pKa: 2.8 and 11.5) within the pH range of 1.2–6.8 is 300 mg/mL, suggesting that the dissolution of metformin hydrochloride tablets should exhibit pH independence. …
    Moisture adsorption and desorption properties of colloidal silicon dioxide and its impact on layer adhesion of a bilayer tablet formulation.

    Moisture adsorption and desorption properties of colloidal silicon dioxide and its impact on layer adhesion of a bilayer tablet formulation.

    Papers - 01/03/2014 - by Jennifer Wang, David Trinkle, George Derbin, Kyle Martin, Shasad Sharif, Divyakant Desai
    A fixed-dose combination tablet formulation of drugs Y and Z was developed using a bilayer tablet approach. Layer I, containing 250 mg of Drug Y, was produced through dry granulation, …
    Impact of the lubricant mixing time on the compactibility and disintegration time for mannitol compacts

    Impact of the lubricant mixing time on the compactibility and disintegration time for mannitol compacts

    Papers - 01/01/2014 - by N Tarlier, B Bataille, G Baylac, P Lefèvre, C Popescu, T Sharkawi
    The aim of this study was to assess how varying the mixing conditions of Magnesium stearate (MgSt) affects the compaction behavior and disintegration time of diverse formulations based on mannitol. …
    Impact of the lubricant mixing time on the compactibility and disintegration time for mannitol compacts

    Impact of the lubricant mixing time on the compactibility and disintegration time for mannitol compacts

    Posters - 01/01/2014 - by N Tarlier, B Bataille, G Baylac, P Lefèvre, C Popescu, T Sharkawi
    The aim of this study was to assess how varying the mixing conditions of Magnesium stearate (MgSt) affects the compaction behavior and disintegration time of diverse formulations based on mannitol. …
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    Tablet-in-cup drug delivery device Drug release modification by tablet geometry

    Posters - 01/01/2014 - by Leonie Hattler, Rainer Alles, Jörg Huwyler, Maxim Puchkov
    AIMS: • Designing TIC devices • Exploring the potential of TIC design for modifying drug release • Simulating TIC drug release in silico
    Characterization of functionalized calcium carbonate as a new pharmaceutical excipient

    Characterization of functionalized calcium carbonate as a new pharmaceutical excipient

    Papers - 01/01/2014 - by Tanja Stirnimann, Jörg Huwyler, Kurt E. Hersberger
    Excipients play a crucial role in developing advanced, reliable formulations with enhanced patient compliance, optimizing plasma concentrations, and minimizing side effects. Modern excipients are expected to exhibit multifunctionality to enable …
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    DuraLac® H: A new, alternative source of anhydrous lactose

    Papers - 01/01/2014 - by Franz K. Penz
    Anhydrous lactose was innovated and patented in the United States in the early 1940s, swiftly gaining traction in pharmaceutical applications. Notably, the initial adoption of anhydrous lactose was primarily concentrated …
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    Tablet-in-cup drug delivery device drug release modification by tablet geometry

    Papers - 01/01/2014 - by Leonie Hattler, Rainer Alles, Jörg Huwyler, Maxim Puchkov
    AIMS: • Designing TIC devices • Exploring the potential of TIC design for modifying drug release • Simulating TIC drug release in silico
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    Investigation of the tableting process in continuous production: influence of feeding and extended dwell time during compression on dependent process variables and tablet properties

    Papers - 01/01/2014 - by Elisabeth Peeters
    Despite the daily production of large quantities of tablets, many of the established processes and formulations have evolved through (suboptimal) trial-and-error experiments, leading to the perception that the pharmaceutical powder …
    Role of the elasticity of pharmaceutical materials on the interfacial mechanical strength of bilayer tablets

    Role of the elasticity of pharmaceutical materials on the interfacial mechanical strength of bilayer tablets

    Papers - 30/11/2013 - by Virginie Busignies, Vincent Mazel, Harona Diarra, Pierre Tchoreloff
    The impact of the elasticity of various pharmaceutical materials on the interfacial adhesion in bilayer tablets was explored. The elastic properties of five pharmaceutical products were assessed based on their …