Effect of additives and operating conditions on tablet weight variation

September 08, 2025

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The article discusses how the addition of silicon compounds and variations in operating conditions impact tablet weight consistency during manufacturing.

Key findings include:

- Additive Impact: The incorporation of highly cohesive silicon compounds into tablet formulations increased weight variation. This suggests that while these additives can enhance compressibility, their cohesive nature may impair powder flowability, leading to inconsistent tablet weights

- Operating Conditions: Adjusting the peripheral velocity of the paddle feeder in the rotary tableting machine was found to decrease tablet weight variation. This indicates that optimizing equipment settings can mitigate the negative effects of certain additives on tablet uniformity

- Flowability Index: The study introduced a flowability index that combines static and dynamic friction properties, providing a quantifiable measure to assess how additives and operating conditions affect tablet weight variation

These insights underscore the importance of carefully selecting excipients and fine-tuning manufacturing parameters to ensure consistent tablet quality.