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  4. How to achieve different release profiles and select excipients for formulation development of modified release oral solid dosage forms
NEWSFEEDS

How to achieve different release profiles and select excipients for formulation development of modified release oral solid dosage forms

October 24, 2023
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The white paper by Societal CDMO takles the following key points:

1 - Importance of modified release oral solid dosage forms in enabling prolonged or targeted drug delivery, leading to improved patient adherence and reduced side effects.

2 - Need for a holistic approach in formulation development, considering factors such as API properties, excipient selection, and dosage form and manufacturing techniques.

3 - Factors affecting the determination of the desired release profile include pharmacokinetics (PK), site of absorption, drug solubility, powder and bulk properties, and particle size distribution.

4 - Handling higher drug loads and choosing appropriate delivery systems like matrix tablets, capsules, or multiparticulate systems pose additional formulation challenges.

5 - Selection of release-controlling polymers and additional excipients is crucial, considering factors such as molecular weight, pH dependency, and processability.

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