How to achieve different release profiles and select excipients for formulation development of modified release oral solid dosage forms
The white paper by Societal CDMO takles the following key points:
1 - Importance of modified release oral solid dosage forms in enabling prolonged or targeted drug delivery, leading to improved patient adherence and reduced side effects.
2 - Need for a holistic approach in formulation development, considering factors such as API properties, excipient selection, and dosage form and manufacturing techniques.
3 - Factors affecting the determination of the desired release profile include pharmacokinetics (PK), site of absorption, drug solubility, powder and bulk properties, and particle size distribution.
4 - Handling higher drug loads and choosing appropriate delivery systems like matrix tablets, capsules, or multiparticulate systems pose additional formulation challenges.
5 - Selection of release-controlling polymers and additional excipients is crucial, considering factors such as molecular weight, pH dependency, and processability.
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