Modern modelling tools for small molecule solid dose manufacturing

January 09, 2026

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The Catalent report highlights the growing role of mathematical and computerized modeling in optimizing continuous manufacturing of oral solid dosage (OSD) forms, including tablets. These advanced tools allow formulators and process engineers to simulate and predict material behavior, compression performance, and tablet quality attributes before scaling up to commercial production. By integrating process parameters, material characteristics, and equipment design, modeling enables more efficient scale-up, reduces experimental workload, and helps mitigate risks such as variability in tablet weight, hardness, and content uniformity. The report emphasizes that these approaches support quality-by-design (QbD) strategies, streamline development timelines, and enhance production efficiency, ultimately enabling safer, more consistent tablets at scale.