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Combination of active ingredients in a single solid form for oral administration: study of formulation and critical compression parameters

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Multilayer tablets have demonstrated efficacy in delivering complex therapeutic solutions, enabling the creation of single-dose forms with multiple active pharmaceutical ingredients (APIs) [16]. In this context, a therapeutic solution for chronic inflammation is proposed in the form of a multilayer tablet containing ibuprofen lysine and sucralfate. The initial part of this thesis focused on developing a three-layer tablet with one layer of ibuprofen lysine encased by two layers of sucralfate, designed for immediate release of the active substances in the stomach. The second part aimed to enhance the understanding of challenges associated with manufacturing multilayer tablets, beginning with fundamental excipients. Finally, a design of experiments was conducted on formulation and process parameters to manufacture a bilayer tablet containing ibuprofen lysine and sucralfate.
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