Determination of ribbon solid fraction in roll compaction using ibuprofen DC100

April 14, 2025

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The study titled "Determination of Ribbon Solid Fraction in Roll Compaction using Ibuprofen DC100" focuses on developing a Process Analytical Technology (PAT) for in-line measurement of ribbon solid fraction during roll compaction. Utilizing in-line laser triangulation, the researchers measured ribbon thickness post-compaction to determine elastic recovery while the ribbons remained attached to the roll surface. They discovered that the ratio between total elastic recovery and in-line elastic recovery is specific to each formulation and remains unaffected by process parameters. This finding allows for the prediction of ribbon solid fraction when the solid fraction at the roll gap is known. The study employed Ibuprofen DC100 as a model drug to assess the effectiveness of direct compression techniques in tablet formulation. The results demonstrated that both mass flow measurement and the Midoux model accurately predicted ribbon solid fraction, highlighting the potential of this PAT approach to enhance monitoring and control in roll compaction processes.