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    Real-time prediction of dissolution profiles of coated oral dosage forms

    Real-time prediction of dissolution profiles of coated oral dosage forms

    Papers - 21/10/2024 - by Stephan Sacher, Elisabeth Fink, Carolina Alva, Jesús Alberto Afonso Urich, Aygün Doğan, Vanessa Herndler, Ioannis Koutsamanis, Varun Kushwah, Anna Peter, Sharareh Salar-Behzadi, Katrina Wilfling, Sandra Stranzinger, Manuel Zettl, Xin Feng, Maxwell Korang-Yeboah, Huiquan Wu, Johannes G. Khinast
    Optical coherence tomography (OCT) has become an in-line monitoring method for pharmaceutical coating processes based on a representative sample size. In this study, a method was developed to correlate coating …
    Image Effects of omitting titanium dioxide from the film coating of a pharmaceutical tablet

    Effects of omitting titanium dioxide from the film coating of a pharmaceutical tablet

    Newsfeeds - 11/06/2024 -
    This case study investigates the impact of removing titanium dioxide (TiO2) from the film coating of pharmaceutical tablets, in light of impending EU regulations banning TiO2 in pharmaceuticals. The study …
    Effect of compression process parameters on the physical properties and in vitro release mechanism of the press-coated nifedipine matrix sustained-release tablets

    Effect of compression process parameters on the physical properties and in vitro release mechanism of the press-coated nifedipine matrix sustained-release tablets

    Papers - 01/11/2023 - by Yibin Guo, Peifu Xiao, Heyang Dong, Xueting Guo, Tian Yin, Yu Zhang, Haibing He, Yanjiao Wang, Jingxin Gou, Xing Tang
    Our objective is to elucidate the impact of compression process parameters on the physical characteristics and release kinetics of press-coated tablets (PCTs) with dual reservoirs. The critical compression force, marking …
    Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa

    Pharmaceutical development of film-coated mini-tablets with losartan potassium for Epidermolysis Bullosa

    Papers - 05/03/2022 - by Valentinë Elezaj, Ard Lura, Luis Canha, Jörg Breitkreutz
    Epidermolysis bullosa is a genetically heterogeneous skin fragility disorder that manifests with multiorgan involvement, often evident in newborn children. The condition leads to severe progressive fibrosis following skin blistering, mucosal …
    Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting

    Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting

    Papers - 26/06/2020 - by Ramy N. Elsergany, Lai Wah Chan, Paul Wan Sia Heng
    Compacting tablets within a multiple-unit pellet system (MUPS) has been widely acknowledged as potentially challenging. Consequently, there is a growing demand for non-segregating cushioning agents to alleviate the adverse effects …
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    Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting

    Papers - 26/06/2020 - by Ramy N. Elsergany, Lai Wah Chan, Paul Wan Sia Heng
    Compaction of multiple-unit pellet system (MUPS) tablets has been extensively reported to be potentially challenging. Thus, there is a need for non-segregating cushioning agents to mitigate the deleterious effect of …
    Partial tablet coating by 3D printing

    Partial tablet coating by 3D printing

    Papers - 01/05/2020 - by Eleni Tsintavi, Dimitrios M. Rekkas, Ruggero Bettini
    Over the past decade, there has been a growing interest in 3D printing (3DP) technology within the pharmaceutical field, addressing various challenges such as on-demand manufacturing at the point of …
    A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets

    A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets

    Papers - 01/01/2020 - by Tze Ning Hiew, Yu Harn Tian, Huei Ming Tan, Paul Wan Sia Heng
    The potential harm to the drug diffusion coat barrier of controlled-release pellets due to compaction force during the preparation of multiple-unit pellet system tablets is a significant concern. Prior research …
    Excipient–process interactions and their impact on tablet compaction and film coating

    Excipient–process interactions and their impact on tablet compaction and film coating

    Papers - 01/11/2014 - by Preetanshu Pandey, Dilbir S. Bindra, Shruti Gour, Jade Trinh, David Buckley, Sherif Badawy
    The aim of this investigation was to examine the influence of minor formulation components (sodium lauryl sulfate: SLS, and magnesium stearate: MgSt) and the manufacturing process on the compaction properties …