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    Nano_on_table_transparent

    AustinPx Invests in Pharmaceutics and Manufacturing Capabilities to Accelerate Drug Development

    Newsfeeds - 11/04/2024 -
    AustinPx, a prominent contract development and manufacturing organization (CDMO) focusing on enhancing the bioavailability of orally delivered small molecule drug candidates, has announced the acquisition of cutting-edge equipment to bolster …
    Illustration article Interphex

    KORSCH America highlights latest tableting technology during Interphex 2024

    Newsfeeds - 03/04/2024 -
    KORSCH America Inc., division of KORSCH AG., a leading name in the pharmaceutical equipment manufacturing industry, is preparing its participation at Interphex in New York. Scheduled from April 16th to …
    Swift Single Step Scale up from Compaction Simulator to Production Rotary Press

    Swift Single Step Scale up from Compaction Simulator to Production Rotary Press

    Papers - 21/03/2023 - by Moritz Rosch, Friederike Gütter
    The scale up process of tablets can be influenced by many factors that can occur during process development. The development can be highly catalyzed by compaction simulators, which allow for …
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    Production challenges of tablets containing lipid excipients: case study using cannabidiol as drug model

    Papers - 21/01/2023 - by Koch Nathan, Jennotte Olivier, Toussaint Céline, Lechanteur Anna, Evrard Brigitte
    This study pursued dual objectives. Firstly, it sought to identify the most effective lipid solid dispersion for cannabidiol from a range of lipid excipients (Gelucire® 50/13, 48/16, 44/14, and Labrasol®) …
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    Upscaling of external lubrication from a compaction simulator to a rotary tablet press

    Papers - 01/01/2023 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with …
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    Screening of lubricants towards their applicability for external lubrication

    Papers - 28/12/2022 - by Cedrine de Backere, Margot Surmont, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    Decreasing tensile strength and prolonged disintegration are linked to internal lubrication. These adverse effects can be mitigated by employing external lubrication. In this present investigation, a compaction simulator was utilized …
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    Usage of compaction simulators for the powder compression characterization – advantages and limitations

    Papers - 26/12/2022 - by Nenad Nikolić, Tijana Miletić, Jovana Kovačević, Djorđe Medarević, Svetlana Ibrić
    Compaction simulators are crafted as machines capable of conducting a thorough analysis of the powder compaction process. The detailed examination of powder compression and compaction, along with material characterization, assumes …
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    The Overview of Oral Solid Dosage Forms and Different Excipients Used for Solid Dosage Formulation

    Papers - 24/08/2022 - by Ms. Kiran Rameshbhai Dudhat
    In the development of pharmaceutical dosage forms, the choice of excipients plays a pivotal role in both preformulation and formulation research. The physical, mechanical, and chemical attributes of excipients exert …
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    Impact of alternative lubricants on process and tablet quality for direct compression

    Papers - 14/07/2022 - by Cedrine de Backere, Julian Quodbach, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    In this study, the utilization of magnesium stearate (MgSt) as an internal lubricant has been linked to a decrease in tensile strength and prolonged disintegration and dissolution times. The current …
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    Manufacturing of mini-tablets. Focus and impact of the tooling systems

    Papers - 29/04/2022 - by Ard Lura, Jörg Breitkreutz
    Mini-tablets are gaining significance in the pharmaceutical industry, particularly for special patient groups like pediatrics, as highlighted in various clinical studies and by organizations. These mini-tablets can be produced on …
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    Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press

    Papers - 25/03/2022 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    The incorporation of internal lubrication is often associated with a decline in tabletability, and various factors such as the deformation mechanism, lubricant type, lubricant blending time, and paddle speed (PS) …
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    Effect of binder type and lubrication method on the binder efficacy for direct compression

    Papers - 25/09/2021 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    1. Introduction: The incorporation of a binder into a direct compression formulation aims to enhance tablet tensile strength and mitigate tablet defects. The internal blending of magnesium stearate (MgSt) is …