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5 key elements qbd in pharma image

5 key elements of quality by design in pharma

Newsfeeds - 10/03/2025 -
The article "5 Key Elements Of Quality By Design In Pharma" discusses the importance of incorporating quality into every stage of the pharmaceutical manufacturing process, starting from research and development. …
Systematic investigation of the impact of screw elements in continuous wet granulation

Systematic investigation of the impact of screw elements in continuous wet granulation

Papers - 01/12/2024 - by Katharina Kiricenko, Robin Meier, Peter Kleinebudde
Twin-screw wet granulation (TSG) is a continuous manufacturing method used to produce granules either as the final dosage form or as an intermediate step before tableting or capsule filling. Successful …
Image The Effect of Formulation Variables on the Manufacturability of Clopidogrel Tablets via Fluidized Hot-Melt Granulation

The effect of formulation variables on the manufacturability of clopidogrel tablets via fluidized hot-melt granulation

Newsfeeds - 16/05/2024 -
This study investigates the challenges faced by solid pharmaceutical formulations containing class II active pharmaceutical ingredients (APIs) due to limited solubility, which affects their behavior in the body. Computational tools …
Application of Response Surface Methodology to Improve the Tableting Properties of Poorly Compactable and High-Drug-Loading Canagliflozin Using Nano-Sized Colloidal Silica

Application of response surface methodology to improve the tableting properties of poorly compactable and high-drug-loading canagliflozin using nano-sized colloidal silica

Papers - 29/10/2023 - by Majed Alrobaian, Ahmed Alalaiwe, Ziyad S. Almalki, Mohamed H. Fayed
Creating a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with challenging flow and compaction properties at a high API load poses a considerable challenge. This study …
Effect of geometrical features on the capping behavior of biconvex tablets

Effect of geometrical features on the capping behavior of biconvex tablets

Papers - 03/09/2023 - by Vincent Mazel, Cléo Garcia, Pierre Tchoreloff
Capping is a prevalent issue in the pharmaceutical tablet manufacturing process, influenced by both process and formulation parameters. This study systematically examined the impact of the geometrical features of biconvex …
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Production challenges of tablets containing lipid excipients: Case study using cannabidiol as drug model

Papers - 25/02/2023 -
The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and inorganic carriers (colloidal …
20210421_Webinar_DOE_on_STYL'One_Nano_v3 BL

Design of Experiments (DoE) to better understand tablet formulations

Webinar Replays - 15/04/2021 - by Mariana Bezerra, Bruno Leclercq
Mariana Bezerra (De Montfort University, Leicester UK) tells you more on DoE and the MEDELPHARM Science Lab shows how it can be performed on a STYL'One nano.
Partial tablet coating by 3D printing

Partial tablet coating by 3D printing

Papers - 01/05/2020 - by Eleni Tsintavi, Dimitrios M. Rekkas, Ruggero Bettini
Over the past decade, there has been a growing interest in 3D printing (3DP) technology within the pharmaceutical field, addressing various challenges such as on-demand manufacturing at the point of …
Continuous single-step wet granulation with integrated in-barrel-drying

Continuous single-step wet granulation with integrated in-barrel-drying

Papers - 01/08/2018 - by Adrian Schmidt, Hans de Waard, Peter Kleinebudde, Markus Krumme
Objective: This study aimed to explore the feasibility of integrating continuous wet granulation and drying into a twin-screw granulator, with the objective of producing (pre-)dried granules in a single-step process …