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    Image flexible modelling of the dissolution performance of directly compressed tablets

    Flexible modelling of the dissolution performance of directly compressed tablets

    Newsfeeds - 08/10/2024 -
    This study proposes a compartmental disintegration and dissolution model to predict and evaluate the dissolution behavior of directly compressed tablets. The model consists of three compartments (Bound, Disintegrated, and Dissolved) …
    Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets

    Investigation of dispersion kinetics of particulate lubricants and their effect on the mechanical strength of MCC tablets

    Papers - 26/09/2023 - by Daniel Puckhaber, Arno Kwade, Jan Henrik Finke
    Tablets are frequently manufactured by incorporating particulate lubricants internally, a practice that is recognized for its potential to diminish the mechanical strength of the tablets. This decline is attributed to …
    Advanced Analysis of Disintegrating Pharmaceutical Compacts Using Deep Learning-Based Segmentation of Time-Resolved Micro-Tomography Images

    Advanced analysis of disintegrating pharmaceutical compacts Using deep learning-based segmentation of time-resolved micro-tomography images

    Papers - 22/08/2023 - by Samuel Waldner, Erwin Wendelspiess, Pascal Detampel, Christian M. Schlepütz, Jörg Huwyler, Maxim Puchkov
    Understanding the mechanism behind the disintegration of pharmaceutical tablets remains largely incomplete. Despite the crucial need to regulate the disintegration process to optimize the bioavailability of active pharmaceutical ingredients and …
    Downstream processing of amorphous solid dispersions into orodispersible tablets

    Downstream processing of amorphous solid dispersions into orodispersible tablets

    Papers - 25/01/2023 - by Marcel Kokott, Stefan Klinken, Jörg Breitkreutz, Raphael Wiedey
    The development of patient-friendly oral solid dosage forms for amorphous solid dispersions (ASDs) remains a challenging task. Orodispersible tablets (ODTs) present a promising alternative to enhance patient compliance. Two distinct …
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    Tablet disintegratability: sensitivity of superdisintegrants to temperature and compaction pressure

    Papers - 06/12/2022 - by Audrey Yi Zheng, Paul Wan Sia Heng, Lai Wah Chan
    Tablet disintegration is a crucial prerequisite for drug dissolution and absorption. While the disintegration test conventionally takes place at 37 °C, intragastric temperature variations can occur due to meals or …
    A generalized image analytical algorithm for investigating tablet disintegration

    A generalized image analytical algorithm for investigating tablet disintegration

    Papers - 31/05/2022 - by Jian X. Wu, Emma Balantic, Frans van den Berg, Jukka Rantanen, Birgitte Nissen, Anders V. Friderichsen
    Commonly employed techniques for assessing tablet disintegration rely on visual observations, introducing a potential for user-dependent outcomes. In response to this issue, a universally applicable image analysis algorithm has been …
    Tablet disintegration and dispersion under in vivo-like hydrodynamic conditions

    Tablet disintegration and dispersion under in vivo-like hydrodynamic conditions

    Papers - 16/01/2022 - by Jan Lenz, Frederik Fuest, Jan Henrik Finke, Heike Bunjes, Arno Kwade, Michael Juhnke
    Disintegration and dispersion are crucial functional properties of tablets, playing a key role in achieving the desired release of the active pharmaceutical ingredient (API). The standard disintegration test (SDT), as …
    Immediate-release formulations produced via twin-screw melt granulation: systematic evaluation of the addition of disintegrants

    Immediate-release formulations produced via twin-screw melt granulation: systematic evaluation of the addition of disintegrants

    Papers - 16/06/2021 - by Kristina E. Steffens, Karl G. Wagner
    The present study investigated the impact of the location and quantity of various superdisintegrants on the characteristics of tablets produced through twin-screw melt granulation (TSMG). Sodium-croscarmellose (CCS), crospovidone (CPV), and …
    Impact of incorporated drugs on material properties of amorphous solid dispersions

    Impact of incorporated drugs on material properties of amorphous solid dispersions

    Papers - 28/12/2020 - by Karsten Flügel, Katharina Schmidt, Lena Mareczek, Michael Gäbe, Robert Hennig, Markus Thommes
    Despite the widespread use of amorphous solid dispersions (ASD) for poorly water-soluble drugs in the market, the formulation development of ASDs remains challenging. In the process of developing novel drugs, …
    Functionality of disintegrants with different mechanisms after roll compaction

    Functionality of disintegrants with different mechanisms after roll compaction

    Papers - 01/06/2020 - by Sabrina Berkenkemper, Hannah Lou Keizer, Marc Lindenberg, Anikó Szepes, Peter Kleinebudde
    The objective of this study was to assess the functionality of two disintegrants, namely crospovidone and croscarmellose sodium, in tablet formulations processed through roll compaction followed by tableting. The investigation …
    Structure-properties relationship in the evaluation of alginic acid functionality for tableting

    Structure-properties relationship in the evaluation of alginic acid functionality for tableting

    Papers - 01/04/2020 - by Rihab Benabbas, Noelia M. Sanchez-Ballester, Bernard Bataille, Laurent Leclercq, Tahmer Sharkawi, Ian Soulairol
    This study aims to explore the interrelation between the structural, molecular, and particulate attributes of alginic acid and its functional traits in direct compression, encompassing tabletability, compressibility, elasticity, deformation mechanism, …
    Modeling of disintegration and dissolution behavior of mefenamic acid formulation using numeric solution of Noyes-Whitney equation with cellular automata on microtomographic and algorithmically generated surfaces

    Modeling of disintegration and dissolution behavior of mefenamic acid formulation using numeric solution of Noyes-Whitney equation with cellular automata on microtomographic and algorithmically generated surfaces

    Papers - 03/12/2018 - by Reiji Yokoyama, Go Kimura, Christian Schlepütz, Jörg Huwyler, Maxim Puchkov
    Manufacturing parameters can significantly influence the dissolution and disintegration of solid dosage forms. In alignment with Process Analytical Technology (PAT) and Quality by Design (QbD) approaches, computer-based technologies offer the …