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Take-off sensor as a tool for sticking assessment during tablet development

Take-off sensor as a tool for sticking assessment during tablet development

Papers - 21/03/2024 - by Adrien Pelloux, Delphine Ach-Hubert, Sixtine Caquant

More than 70% of candidate drugs have low solubility (BCS Class II and IV) (Nikolakakis et al. 2017). Making tablets with low solid fraction improves the dissolution rate (Van der …

Sticking Detection by Repeated Compactions on a Single Tablet

Sticking detection by repeated compactions on a single tablet

Papers - 21/11/2023 - by James Thomas, Phuong Bui, Antonios Zavaliangos

Tablet sticking in the context of tablet manufacturing refers to the buildup of tablet material on the punch after multiple compaction cycles. The occurrence of sticking can impact tablet weight, …

Fig.-2-Tableting-study

Tableting of liquid form active ingredient with high performance liquid carrier

Newsfeeds - 07/11/2023 -

The article discusses the use of FLORITE, a macro porous calcium silicate, as a practical alternative to liquid carriers for tableting formulations with liquid active ingredients.Fish oil was utilized as …

Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of Acetylsalicylic Acid Tablets

Impact of amylose-amylopectin ratio of starches on the mechanical strength and stability of acetylsalicylic acid tablets

Papers - 20/04/2022 - by Natalia Veronica, Celine Valeria Liew, Paul Wan Sia Heng

The interaction of starch with moisture is primarily influenced by its two key components, amylose and amylopectin. This investigation delved into the moisture sorption properties of starches with varying amylose-amylopectin …

Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa

Pharmaceutical development of film-coated mini-tablets with losartan potassium for Epidermolysis Bullosa

Papers - 05/03/2022 - by Valentinë Elezaj, Ard Lura, Luis Canha, Jörg Breitkreutz

Epidermolysis bullosa is a genetically heterogeneous skin fragility disorder that manifests with multiorgan involvement, often evident in newborn children. The condition leads to severe progressive fibrosis following skin blistering, mucosal …

Structure-property relationship of amorphous maltitol as tableting excipient

Papers - 13/10/2020 - by Franck Bourduche, Noelia M. Sanchez-Ballester, Bernard Bataille, Philippe Lefèvre, Tahmer Sharkawi

Maltitol exhibits noteworthy characteristics in comparison to mannitol or sorbitol, two commonly used polyols as pharmaceutical excipients for tablet compaction. In this investigation, the attributes of amorphous maltitol were explored …

Polyglycerol esters of fatty acids as safe and stable matrix forming tableting excipients: a structure-function analysis

Polyglycerol esters of fatty acids as safe and stable matrix forming tableting excipients: a structure-function analysis

Papers - 01/08/2020 - by Sharareh Salar Behzadi, Julia Karrer, Valon Demiri, Brenda Barrios, Carolina Corzo, Claudia Meindl, Dirk Lochmann, Sebastian Reyer

This study introduces an innovative approach to developing stable extended-release matrix tablets through direct compaction. The chosen molecules belong to polyglycerol esters of fatty acids (PGFAs), a category of lipid-based …

Study of the Lactobacillus rhamnosus Lcr35® properties after compression and proposition of a model to predict tablet stability

Study of the Lactobacillus rhamnosus Lcr35® properties after compression and proposition of a model to predict tablet stability

Papers - 01/11/2014 - by Claudia Muller, Vincent Mazel, Caroline Dausset, Virginie Busignies, Stéphanie Bornes, Adrien Nivoliez, Pierre Tchoreloff

The acknowledged positive impacts of probiotic bacteria on human health have sparked increasing interest in pharmaceutical research and development. However, for these bacteria to remain viable upon reaching their target, …