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    A strategy to optimize precompression pressure for tablet manufacturing based on in-die elastic recovery

    A strategy to optimize precompression pressure for tablet manufacturing based on in-die elastic recovery

    Papers - 07/03/2024 - by Gerrit Vreeman, Changquan Calvin Sun
    A strategy for optimizing precompression pressure, utilizing in-die elastic recovery, has been devised to effectively tackle tablet lamination caused by air entrapment. This approach involves intentionally intensifying the air entrapment …
    Air entrapment during tablet compression – Diagnosis, impact on tableting performance, and mitigation strategies

    Air entrapment during tablet compression – Diagnosis, impact on tableting performance, and mitigation strategies

    Papers - 05/03/2022 - by Gerrit Vreeman, Changquan Calvin Sun
    The occurrence of air entrapment during powder compression, a phenomenon capable of causing tablet defects during decompression and ejection, was investigated using celecoxib powder. This involved a comparison of in-die …
    Lamination of pharmaceutical tablets: classification and influence of process parameters

    Lamination of pharmaceutical tablets: classification and influence of process parameters

    Papers - 23/10/2021 - by V. Mazel, P. Tchoreloff
    The occurrence of lamination is a prevalent issue in the pharmaceutical tablet manufacturing process, representing a failure of the tablet along one or more planes parallel to the surface and …
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    Troubleshooting tablet defects in no-time

    White Papers - 12/10/2021 - by Bruno Leclercq
    There are numerous tablet defects: chipping, picking & sticking, cracking, lamination & capping to name a few.Lamination & capping often occur during scale-up and are main issues in our industry. …
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    A fundamental step in your tablet development

    Bulletins - 01/09/2021 - by Adrien Pelloux
    Formulation development and technical transfer from lab to production can be challenging and requires a deep knowledge of your formulation. The integrated and intuitive data analysis features drive formulators and …
    The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of itraconazole-HPMCAS spray dried dispersions

    The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of itraconazole-HPMCAS spray dried dispersions

    Papers - 16/09/2020 - by Moshe Honick, Sharmila Das, Stephen W. Hoag, Francis X. Muller, Alaadin Alayoubi, Xin Feng, Ahmed Zidan, Muhammad Ashraf, James E. Polli
    Spray-dried dispersions (SDDs) hold considerable potential in enhancing the oral bioavailability of drugs with limited water solubility. Nevertheless, SDDs often exhibit material attributes, such as small particle size, low bulk …
    Influence of the unloading conditions on capping and lamination: Study on a compaction simulator

    Influence of the unloading conditions on capping and lamination: Study on a compaction simulator

    Papers - 15/08/2019 - by Vincent Mazel, Léo Desbois, Pierre Tchoreloff
    Capping and lamination, traditional challenges in industrial processes, can pose difficulties when scaling up solid dosage forms. Previous research has demonstrated that altering the unloading conditions, such as triaxial decompression …
    Etude de la compression pharmaceutique à l'aide d'une approche de mécanique des milieux continus

    Etude de la compression pharmaceutique à l'aide d'une approche de mécanique des milieux continus

    Papers - 20/12/2018 - by Vincent Mazel
    L'ensemble de mon parcours de recherche, entamé il y a plus de 10 ans, a été centré sur la science des matériaux. J'ai eu la chance de travailler dans des …
    Lamination of biconvex tablets: numerical and experimental study

    Lamination of biconvex tablets: numerical and experimental study

    Papers - 05/05/2018 - by Vincent Mazel, Harona Diarra, Jérôme Malvestio, Pierre Tchoreloff
    Capping and lamination are prevalent issues in the pharmaceutical tablet manufacturing process. Although these problems are often addressed collectively, they represent distinct failure patterns in tablets and consequently involve different …
    Lamination of pharmaceutical tablets due to air entrapment: direct visualization and influence of the compact thickness

    Lamination of pharmaceutical tablets due to air entrapment: direct visualization and influence of the compact thickness

    Papers - 30/01/2015 - by V. Mazel, V. Busignies, H. Diarra, P. Tchoreloff
    Capping and lamination pose common challenges in the industrial production of pharmaceutical tablets, with various proposed reasons to explain these occurrences. Air entrapment is suggested as a potential factor in …