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    Magnesium Stearate Fatty Acid Composition, Lubrication Performance and Tablet Properties

    Magnesium Stearate Fatty Acid Composition, Lubrication Performance and Tablet Properties

    Papers - 05/11/2024 - by Natalia Veronica, Paul Wan Sia Heng, Celine Valeria Liew
    This research paper investigates the impact of different fatty acid compositions in magnesium stearate (MgSt), a common tablet lubricant, on tablet properties. The study focused on the significance of stearate …
    Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

    Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

    Papers - 15/08/2024 - by Dingeman L.H. Van Der Haven, René Jensen, Maria Mikoroni, Umair Zafar, James A. Elliott, Ioannis S. Fragkopoulos
    The magnitude of frictional forces during the ejection of porous pharmaceutical tablets is crucial in determining the likelihood of tabletting defects. In this study, we conduct a systematic comparison of …
    Selection of lubricant type and concentration for orodispersible tablets

    Selection of lubricant type and concentration for orodispersible tablets

    Papers - 25/05/2024 - by Audrey Yi Zheng, Mahn Teng Loh, Paul Wan Sia Heng, Lai Wah Chan
    Lubricants play a vital role in most tablet formulations by aiding powder flow, preventing adhesion to tableting tools, and facilitating tablet ejection. Although magnesium stearate (MgSt) is commonly used as …
    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Papers - 07/01/2024 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Bindhumadhavan Gururajan, Supriya Rane, Arno Kwade
    Most tablets produced include lubricants to minimize friction during ejection. However, in the case of plastically deforming materials such as microcrystalline cellulose (MCC), internal incorporation of lubricants is known to …
    Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets

    Investigation of dispersion kinetics of particulate lubricants and their effect on the mechanical strength of MCC tablets

    Papers - 26/09/2023 - by Daniel Puckhaber, Arno Kwade, Jan Henrik Finke
    Tablets are frequently manufactured by incorporating particulate lubricants internally, a practice that is recognized for its potential to diminish the mechanical strength of the tablets. This decline is attributed to …
    Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility

    Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility

    Papers - 04/04/2023 - by Daniel Puckhaber, Anna-Lena Voges, Supriya Rane, Sarah David, Bindhumadhavan Gururajan, Jan Henrik Finke, Arno Kwade
    Modeling the structural and mechanical properties of tablets composed of multiple components, based on a minimal amount of experimental data, is of great interest to minimize the time and cost …
    Screening of lubricants towards their applicability for external lubrication

    Screening of lubricants towards their applicability for external lubrication

    Papers - 28/12/2022 - by Cedrine de Backere, Margot Surmont, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    Decreasing tensile strength and prolonged disintegration are linked to internal lubrication. These adverse effects can be mitigated by employing external lubrication. In this present investigation, a compaction simulator was utilized …
    A compactibility-based lubricant dispersion model describing the effect of formulation and paddle speed

    A compactibility-based lubricant dispersion model describing the effect of formulation and paddle speed

    Papers - 25/11/2022 - by Daniel Puckhaber, Ann Kathrin Schomberg, Arno Kwade, Jan Henrik Finke
    In rotary tablet presses, the entry of powder into the dies is commonly facilitated by a paddle feeder. In formulations with internal lubrication, the shear forces generated by paddle rotation …
    Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to Conventionally Sized Orodispersible Tablets

    Impact of lubrication on key properties of orodispersible minitablets in comparison to conventionally sized orodispersible tablets

    Papers - 05/09/2022 - by Jennifer Kuck, Jörg Breitkreutz
    Orodispersible minitablets (ODMTs) offer several advantages such as ease of swallowability, dose flexibility, and straightforward manufacturing through direct compression. This study investigates the impact of lubrication on five different co-processed …
    The Overview of Oral Solid Dosage Forms and Different Excipients Used for Solid Dosage Formulation

    The overview of oral solid dosage forms and different excipients used for solid dosage formulation

    Papers - 24/08/2022 - by Ms. Kiran Rameshbhai Dudhat
    In the development of pharmaceutical dosage forms, the choice of excipients plays a pivotal role in both preformulation and formulation research. The physical, mechanical, and chemical attributes of excipients exert …
    Impact of alternative lubricants on process and tablet quality for direct compression

    Impact of alternative lubricants on process and tablet quality for direct compression

    Papers - 14/07/2022 - by Cedrine de Backere, Julian Quodbach, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    In this study, the utilization of magnesium stearate (MgSt) as an internal lubricant has been linked to a decrease in tensile strength and prolonged disintegration and dissolution times. The current …
    Prediction of the impact of lubrication on tablet compactibility

    Prediction of the impact of lubrication on tablet compactibility

    Papers - 05/04/2022 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Mauro Serratoni, Umair Zafar, Edgar John, Michael Juhnke, Arno Kwade
    The tableting process for most pharmaceutical formulations necessitates the incorporation of lubricants to mitigate ejection forces, prevent tooling damage, and address tablet defects. However, the internal addition of lubricants is …