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    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Papers - 07/01/2024 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Bindhumadhavan Gururajan, Supriya Rane, Arno Kwade
    Most tablets produced include lubricants to minimize friction during ejection. However, in the case of plastically deforming materials such as microcrystalline cellulose (MCC), internal incorporation of lubricants is known to …
    Worsened punch sticking by external lubrication with magnesium stearate

    Worsened punch sticking by external lubrication with magnesium stearate

    Papers - 01/01/2024 - by Tianyi Xiang, Changquan Calvin Sun
    Applying magnesium stearate (MgSt) as an external lubricant to tooling is a widely used approach to prevent punch sticking during the compression of powders with a high tendency to stick, …
    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Papers - 08/12/2023 - by Natalia Veronica, Yi Ying Loh, Lydia Xiu Ying Loh, Paul Wan Sia Heng, Celine Valeria Liew
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    Effects of tableting process parameters and powder lubrication levels on tablet surface temperature and moisture content

    Papers - 08/11/2023 - by Komlan Koumbogle, Ryan Gosselin, François Gitzhofer, Nicolas Abatzoglou
    The occurrence of punch sticking poses a recurrent challenge in the pharmaceutical tablet manufacturing process. The moisture content of the powder plays a crucial role in the development of sticking; …
    Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

    Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

    Papers - 06/05/2023 - by Chamara A. Gunawardana, Angela Kong, Debbie Wanapun, Daniel O. Blackwood, C. Travis Powell, Joseph F. Krzyzaniak, Myles C. Thomas, John E. Kresevic, Changquan Calvin Sun
    The adherence of active pharmaceutical ingredient (API) to compaction tooling surfaces, commonly known as punch sticking, can lead to costly downtime or product failures during commercial tablet manufacturing. Magnesium stearate …
    Magnesium stearate surface coverage on tablets and drug crystals: Insights from SEM-EDS elemental mapping

    Magnesium stearate surface coverage on tablets and drug crystals: Insights from SEM-EDS elemental mapping

    Papers - 10/01/2023 - by Chamara A. Gunawardana, Angela Kong, Daniel O. Blackwood, C. Travis Powell, Joseph F. Krzyzaniak, Myles C. Thomas, Changquan Calvin Sun
    We propose the utilization of scanning electron microscopy-based energy dispersive X-ray spectroscopy (SEM-EDS) as a versatile tool for quantifying surface area coverage (SAC) by magnesium stearate (MgSt) on pharmaceutical tablets …
    Upscaling of external lubrication from a compaction simulator to a rotary tablet press

    Upscaling of external lubrication from a compaction simulator to a rotary tablet press

    Papers - 01/01/2023 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with …
    Screening of lubricants towards their applicability for external lubrication

    Screening of lubricants towards their applicability for external lubrication

    Papers - 28/12/2022 - by Cedrine de Backere, Margot Surmont, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    Decreasing tensile strength and prolonged disintegration are linked to internal lubrication. These adverse effects can be mitigated by employing external lubrication. In this present investigation, a compaction simulator was utilized …
    Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to Conventionally Sized Orodispersible Tablets

    Impact of lubrication on key properties of orodispersible minitablets in comparison to conventionally sized orodispersible tablets

    Papers - 05/09/2022 - by Jennifer Kuck, Jörg Breitkreutz
    Orodispersible minitablets (ODMTs) offer several advantages such as ease of swallowability, dose flexibility, and straightforward manufacturing through direct compression. This study investigates the impact of lubrication on five different co-processed …
    The Overview of Oral Solid Dosage Forms and Different Excipients Used for Solid Dosage Formulation

    The overview of oral solid dosage forms and different excipients used for solid dosage formulation

    Papers - 24/08/2022 - by Ms. Kiran Rameshbhai Dudhat
    In the development of pharmaceutical dosage forms, the choice of excipients plays a pivotal role in both preformulation and formulation research. The physical, mechanical, and chemical attributes of excipients exert …
    Impact of alternative lubricants on process and tablet quality for direct compression

    Impact of alternative lubricants on process and tablet quality for direct compression

    Papers - 14/07/2022 - by Cedrine de Backere, Julian Quodbach, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    In this study, the utilization of magnesium stearate (MgSt) as an internal lubricant has been linked to a decrease in tensile strength and prolonged disintegration and dissolution times. The current …
    Lubrication-now-easy-to-use-for-RD-lab-environm.original

    Lubrication now easy-to-use for R&D lab environment

    White Papers - 02/07/2021 - by Bruno Leclercq
    Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the …