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    Modified roller compaction model to account for roll speed effect on powder compaction in dry granulation process

    Modified roller compaction model to account for roll speed effect on powder compaction in dry granulation process

    Papers - 07/05/2024 - by Indu Muthancheri, Mario Rousselin, Anna Espinose, Nicolas Sanchez, Jean-Rene Authelin
    This study presents an enhancement to the roller compaction model originally proposed by [1], incorporating the impact of roll speed on powder compaction during the dry granulation process. The updated …
    Granutools - Granupack Permeability

    Granutools introduces the GranuPack permeability

    Newsfeeds - 06/02/2024 -
    Granutools has introduced the GranuPack Permeability Unit, a revolutionary device for analyzing powder permeability in various packing conditions. Essential for industries like pharmaceuticals, food production, and additive manufacturing, the unit …
    Rotary tablet press - KORSCH

    The critical role of product die filling

    White Papers - 01/02/2024 - by Friederike Guetter
    Product flow and consistent die filling are essential factors for successful tableting. For successful tablet production, many process steps must be harmonized with each other.
    Studies on the influence of high-shear granulation process on the compressibility of microcrystalline cellulose

    Studies on the influence of high-shear granulation process on the compressibility of microcrystalline cellulose

    Papers - 25/09/2022 - by Boyun Xiao, Jiaqi Zhang, Lixin Geng, Xing Tang, Yanjiao Wang, Tian Yin, Yu Zhang, Jingxin Gou, Haibing He
    Microcrystalline cellulose (MCC) serves as a diluent in the formulation of oral solid dosage forms. In this predictive study, the wet granulation process was chosen to produce tablets containing losartan …
    Challenges and solutions in drug product process development from a material science perspective

    Challenges and solutions in drug product process development from a material science perspective

    Papers - 07/04/2022 - by Antonios Fytopoulos, Rohit Ramachandran, Panos M. Pardalos, Fanny Stauffer, Pierre-François Chavez, Julie Fahier, Corentin Larcy, Mehrdad Pasha, Gabrielle Pilcer
    While it is widely acknowledged that comprehending the impact of material attributes on drug product processes is crucial for designing resilient products and processes, the systematic identification of critical process …
    Stress transmission coefficient is a reliable and robust parameter for quantifying powder plasticity

    Stress transmission coefficient is a reliable and robust parameter for quantifying powder plasticity

    Papers - 09/12/2021 - by Gerrit Vreeman, Changquan Calvin Sun
    Existing methods for determining powder plasticity parameters are susceptible to errors in porosity measurements, which stem from inaccuracies in measuring compact density, true density, or both. This study utilized various …
    Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

    Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

    Papers - 01/12/2021 - by Gerrit Vreeman, Changquan Calvin Sun
    Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the indie Heckel analysis has been widely criticized for its sensitivity to several factors, such …
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    Understanding the delamination risk of a trilayer tablet ssing minipiloting tools

    Papers - 01/11/2017 - by Jing Tao, Sophia Robertson-Lavalle, Preetanshu Pandey, Sherif Badawy
    One of the formulation strategies employed to address chemical and physical incompatibility among various drug substances is the use of multilayer tablets. Feasibility studies on multilayer tablets commonly utilize round …
    Compaction of food powders: the influence of material properties and process parameters on product structure, strength, and dissolution

    Compaction of food powders: the influence of material properties and process parameters on product structure, strength, and dissolution

    Papers - 10/08/2017 - by W. Robert Mitchell, Laurent Forny, Tim Althaus, Daniel Dopfer, Gerhard Niederreiter, Stefan Palzer
    Throughout the pressure agglomeration of food powders, achieving control over final product properties remains challenging due to the intricate behaviors of the materials involved. This study aims to enhance the …
    Agglomeration of powders with a new-coupled vibration-compaction device

    Agglomeration of powders with a new-coupled vibration-compaction device

    Papers - 01/01/2017 - by Eric Serris, Olivier Desplat, Olivier Valfort, Phillipe Grosseau, F. Radjai, S. Nezamabadi, S. Luding, J.Y. Delenne
    Recycling of inorganic powder is anticipated to play a pivotal role in the future of "smart factories." The study focuses on a sophisticated three-phase system comprising bauxite, ordinary Portland cement, …
    Evaluation of a rotary tablet press simulator as a tool for the characterization of compaction properties of pharmaceutical products

    Evaluation of a rotary tablet press simulator as a tool for the characterization of compaction properties of pharmaceutical products

    Papers - 01/06/2010 - by F. Michaut, V. Busignies, C. Fouquereau, B. Huet de Barochez, B. Leclerc, P. Tchoreloff
    The Stylcam 100R, designed as a rotary press simulator to replicate speed profiles of rotary tablet presses, has undergone qualification by various laboratories. However, its suitability for investigating powder behavior …