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    Take-off sensor as a tool for sticking assessment during tablet development

    Take-off sensor as a tool for sticking assessment during tablet development

    Papers - 21/03/2024 - by Adrien Pelloux, Delphine Ach-Hubert, Sixtine Caquant
    More than 70% of candidate drugs have low solubility (BCS Class II and IV) (Nikolakakis et al. 2017). Making tablets with low solid fraction improves the dissolution rate (Van der …
    I Holland Test 2

    Successful cooperation yields - anti-stick rewards with Pfizer

    White Papers - 21/11/2023 -
    Sticking is one of the biggest production challenges faced by tablet manufacturers. This article clarifies the challenge and outlines solutions on how to resolve sticking to ensure it is not …
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    Effects of tableting process parameters and powder lubrication levels on tablet surface temperature and moisture content

    Papers - 08/11/2023 - by Komlan Koumbogle, Ryan Gosselin, François Gitzhofer, Nicolas Abatzoglou
    The occurrence of punch sticking poses a recurrent challenge in the pharmaceutical tablet manufacturing process. The moisture content of the powder plays a crucial role in the development of sticking; …
    I Holland Test 2

    How to avoid sticky situations

    White Papers - 10/10/2023 -
    Sticking is one of the biggest production challenges faced by tablet manufacturers. This article clarifies the challenge and outlines solutions on how to resolve sticking to ensure it is not …
    Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

    Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

    Papers - 06/05/2023 - by Chamara A. Gunawardana, Angela Kong, Debbie Wanapun, Daniel O. Blackwood, C. Travis Powell, Joseph F. Krzyzaniak, Myles C. Thomas, John E. Kresevic, Changquan Calvin Sun
    The adherence of active pharmaceutical ingredient (API) to compaction tooling surfaces, commonly known as punch sticking, can lead to costly downtime or product failures during commercial tablet manufacturing. Magnesium stearate …
    presentation Temperature influence on tablet quality attributes

    Assessing temperature influence on tablet quality attributes

    Webinar Replays - 02/03/2023 - by Hanna Grumann, Bruno Leclercq
    "Assessing temperature influence on tablet quality attributes - Using a temperature-controlled die on the STYL’One Evo compaction simulator" - by Hanna Grumann, PhD student at the Institute of Pharmaceutics and …
    tablet_defect.original

    Troubleshooting tablet defects in no-time

    White Papers - 12/10/2021 - by Bruno Leclercq
    There are numerous tablet defects: chipping, picking & sticking, cracking, lamination & capping to name a few.Lamination & capping often occur during scale-up and are main issues in our industry. …
    An in-line, high sensitivity, non-contact sensor for the detection of initiation of sticking

    An in-line, high sensitivity, non-contact sensor for the detection of initiation of sticking

    Papers - 01/03/2020 - by James Thomas, Antonios Zavaliangos
    Objective This paper explores the development and evaluation of a laser sensor designed to identify the onset of sticking during tablet manufacturing. Methodology The device operates on the fundamental principle …
    Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches

    Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches

    Papers - 01/01/2019 - by V. Mazel, H. Diarra, P. Tchoreloff
    The final properties of tablets are predominantly determined during the compaction process by the development of stresses applied to the powder. Any parameter related to the process or product that …