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    Does tablet shape and height influence survival of fluidized bed-granulated living microorganisms during compaction?

    Does tablet shape and height influence survival of fluidized bed-granulated living microorganisms during compaction?

    Papers - 01/06/2025 - by Karl Vorländer, Lukas Bahlmann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    Developing effective probiotic formulations requires gentle processing to preserve the viability of probiotic microorganisms, which is crucial for their health benefits. Fluidized bed spray granulation followed by tablet compression has …
    Using in-line measurement and statistical analyses to predict tablet properties compressed using a Styl’One compaction simulator: A high shear wet granulation study

    Using in-line measurement and statistical analyses to predict tablet properties compressed using a STYL’One compaction simulator: A high shear wet granulation study

    Papers - 16/12/2024 - by Issa Munu, Andrei L. Nicusan, Jason Crooks, Kendal Pitt, Christopher Windows-Yule, Andrew Ingram
    High shear wet granulation (HSWG) is a widely adopted method in tablet manufacturing due to its benefits, including improved flowability, enhanced powder handling, optimized process runtime, controlled size distribution, and …
    Powder_Explosion_Red

    Pharmaceutical granulation: enhancing drug manufacturing efficiency

    Newsfeeds - 11/10/2024 -
    Granulation is a vital process in pharmaceutical manufacturing, where fine powder particles are combined into larger, free-flowing granules. This process is crucial for enhancing the physical properties of drug formulations, …
    tablet white

    A recipe for success: mastering tableting requires understanding ingredient attributes

    Newsfeeds - 12/09/2024 -
    The author discusses the importance of understanding ingredient attributes in the process of tablet manufacturing. It emphasizes that consistently producing high-quality tablets requires more than just creating a successful small-scale …
    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Newsfeeds - 29/08/2024 -
    The review provides an extensive overview of granulation techniques in pharmaceutical manufacturing, comparing traditional and modern methods. It details dry granulation techniques such as slugging, roller compaction, and pneumatic dry …
    Image Fluid Bed And Melt Granulation In Pharmaceutical Manufacturing

    Fluid bed and melt granulation in pharmaceutical manufacturing

    Newsfeeds - 22/07/2024 -
    The article provides an in-depth look at granulation in pharmaceutical manufacturing, emphasizing fluid bed and melt granulation techniques. Granulation is essential for creating high-quality pharmaceuticals due to its benefits in …
    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Papers - 04/06/2024 - by Anil Kumar Vadaga, Sai Shashank Gudla, Gnanendra Sai Kumar Nareboina, Hymavathi Gubbala, Bhuvaneswari Golla
    This comprehensive review examines both modern and traditional granulation techniques in pharmaceutical dosage forms, with a particular focus on dry and wet granulation. The dry granulation methods covered include slugging, …
    Effect of hydroxy propyl cellulose grade and foam quality on foam granulation of a high drug load formulation

    Effect of hydroxy propyl cellulose grade and foam quality on foam granulation of a high drug load formulation

    Papers - 25/05/2024 - by Otilia Koo, Chandrakant Patel, Faranak Nikfar
    Foam granulation presents a relatively novel approach to wet granulation, where foamed binder solutions are introduced to powder mixtures in the mixer. This serves to mitigate issues of localized over-wetting …
    Image Hot-Melt extrusion - from theory to application in pharmaceutical formulation - where are we now

    Hot-melt extrusion: from theory to application in pharmaceutical formulation – where are we now?

    Newsfeeds - 10/04/2024 -
    Hot-melt extrusion (HME) stands as a widely acknowledged and robust technology, effectively enhancing the bioavailability of poorly soluble active pharmaceutical ingredients while offering an efficient continuous manufacturing process. The twin-screw …
    Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior

    Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior

    Papers - 25/03/2024 - by Adwait Pradhan, Brian Phillips, Fengyuan Yang, Kapish Karan, Thomas Durig, Brian Haight, Charlie Martin, Feng Zhang
    Twin-screw melt granulation (TSMG) relies on both dispersive and distributive mixing at the kneading zone to facilitate granule growth, underscoring the pivotal role played by kneading elements in TSMG. Despite …
    Yellow tablets iStock-1218616175

    Flexible granulation

    Newsfeeds - 20/02/2024 -
    The process of pharmaceutical granulation plays a pivotal role in producing solid dosage forms, directly influencing the efficacy, stability, and overall quality of the drug. Within pharmaceutical manufacturing, flexible granulation …
    MUPS KORSCH technology blog

    MUPS - the mixture is what matters

    White Papers - 06/02/2024 - by Friederike Guetter
    MUPS, or “multiple unit pellet system”, is a solid dosage form in which the granulation consists of a mixure of active, coated pellets and powder excipients. MUPS products include, for …
    Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (Echinochloa esculenta) Starch

    Functional and tableting properties of alkali-isolated and phosphorylated Barnyard Millet (Echinochloa esculenta) starch

    Papers - 22/08/2023 - by Pankaj Bhatt, Vipin Kumar, Harsh Rastogi, Mayank Kumar Malik, Raghav Dixit, Sakshi Garg, Garima Kapoor, Suruchi Singh
    The functional and tableting characteristics of barnyard millet starch (Echinochloa esculenta) were examined in its native (alkali-treated) and chemically modified (phosphorylated) forms. The grains underwent pulverization, soaking, and grinding before …
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    A review on formulation of effervescent tablet

    Papers - 01/04/2023 -
    The effervescent tablets are formulated by various methods like wet granulation and dry granulation. One of the most popular ways of administering a medicament is by converting it to its …
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    An introduction to spheronization (or marumerization)

    White Papers - 14/02/2023 -
    Spheronization (or marumerization) is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 …
    Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

    Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

    Papers - 25/07/2022 - by Shang Jun Loo, Paul Wan Sia Heng, Lai Wah Chan
    Micronized drug powders are often impractical for use as tableting feed to create minitablets due to their cohesiveness and poor flow properties. The addition of fumed silica (fSi) within an …
    MEDELPHARM Science Lab powder angle of repose

    Assess the impact of your granulation process parameters with the STYL'One Evo

    Bulletins - 01/03/2022 - by Sixtine Caquant, Adrien Pelloux
    Powder granulation is commonly used in the pharmaceutical industry to improve flowability and compactibility of powders. In this case our customer wanted to develop a new directcompression grade of excipient …
    Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

    Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

    Papers - 01/06/2020 - by V. Vanhoorne, R. Almey, T. De Beer, C. Vervaet
    In this present study, we explored whether the moisture-mediated polymorphic transition from δ- to β-mannitol observed during twin screw granulation (TSG) could occur in formulations with a high drug load. …
    Influence of formulation parameters on redispersibility of naproxen nanoparticles from granules produced in a fluidized bed process

    Influence of formulation parameters on redispersibility of naproxen nanoparticles from granules produced in a fluidized bed process

    Papers - 16/04/2020 - by Martin Wewers, Stefan Czyz, Jan Henrik Finke, Edgar John, Bernard Van Eerdenbrugh, Michael Juhnke, Heike Bunjes, Arno Kwade
    Reducing the particle size of active pharmaceutical ingredients is an efficient strategy for addressing challenges related to poor aqueous solubility. To enhance stability and patient convenience, nanosuspensions are often converted …
    Powders flowability assessment in granular compaction: What about the consistency of Hausner ratio?

    Powders flowability assessment in granular compaction: What about the consistency of Hausner ratio?

    Papers - 01/09/2019 - by A. Saker, M.-G. Cares-Pacheco, P. Marchal, V. Falk
    This study evaluates powder flowability during granular compaction under free surface conditions, utilizing the Hausner ratio (HR) as the flowability index. Various pharmaceutical and food powders were scrutinized using three …