Application bulletins

Explore our collection of application bulletins featuring practical studies and real-world case examples. Learn how STYL’One technology supports research, formulation, and process optimization across the tableting and powder compression fields.

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Dry granulation in solid oral formulation- advantages of spray-dried mannitol - image

Dry granulation in solid oral formulation: advantages of spray-dried mannitol in roll compaction

Newsfeed - 25/09/2025 -

The article explores the benefits of spray-dried mannitol as a filler/binder in dry granulation via roller compaction, a technique particularly suited to moisture- and heat-sensitive APIs since it avoids wet …

Influence of material and process parameters on the correction factor Kp in roller compaction simulation

Papers - 05/04/2025 - by Layla Hassan, René Jensen, Zahra Sodal, Frederik Hellesøe Ørtoft, Lasse I. Blaabjerg, Umair Zafar

It is commonly accepted that compaction simulators can mimic the uniaxial compression process of roller compactors. To align the simulation output with actual product relative density, a correction factor (Kp) …

MEDELPHARM's participation at AAPS PharmSci 360 2024: Innovations in tablet formulation

Newsfeed - 30/10/2024 - by Gabrielle Dupont

At the recent AAPS PharmSci 360, held from October 20th-23rd, 2024, in Salt Lake City, MEDELPHARM showcased its latest advancements in tablet formulation technology alongside KORSCH America. This collaboration featured …

An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

Papers - 28/10/2024 - by Yiwang Guo, Lizbeth Martinez, Arnesh Palanisamy, Bindhu Gururajan, Changquan Calvin Sun

Ribbon porosity is essential to monitor in roller compaction. This study compares six porosity measurement methods—caliper, X-ray microtomography (µCT), near-infrared spectroscopy (NIR), laser triangulation, mercury intrusion porosimetry (MIP), and GeoPyc—using …

Modified roller compaction model to account for roll speed effect on powder compaction in dry granulation process

Papers - 07/05/2024 - by Indu Muthancheri, Mario Rousselin, Anna Espinose, Nicolas Sanchez, Jean-Rene Authelin

This study presents an enhancement to the roller compaction model originally proposed by [1], incorporating the impact of roll speed on powder compaction during the dry granulation process. The updated …

Modeling of STYL'One Evolution correction factors for multicomponent mixtures scaling-up to roller compaction

Papers - 11/04/2024 - by Fabia Arpago, Agostino Dall'Ara

Roll compaction (RC) stands as a cost-efficient dry granulation technique extensively utilized in the pharmaceutical sector. In the initial stages of formulation development, particularly when resources are constrained, the ability …

Elucidating the impact of material properties on tablet manufacturability for binary paracetamol blends

Papers - 17/11/2023 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl

Objective: While the mechanical properties of paracetamol and microcrystalline cellulose (MCC) are well-documented in the literature, there is a recognized need for a more nuanced understanding of the material properties …

A study on the pelletization and solidification of Cs-contaminated soil after soil washing

Papers - 01/06/2023 - by Jun-Yeol An, Ki-Tae Yang, Min-Ho Lee, Sang-Hyun Lim, Sun-Il Kim, Jong-Soon Song

The release of radioactive substances during a nuclear power plant accident can result in soil contamination over a wide area. Soil washing, employed as a decontamination technique for cesium (Cs)-contaminated …

Solidification of radioactive soil waste through volume reduction and stabilization: Characteristic evaluation and waste acceptance criteria satisfaction

Papers - 01/05/2023 - by Sang-Hyun Lim, Sang-Heon Lee, Jong-Soon Song, Ki-Hong Kim

The disposal of radioactive soil waste poses a global environmental challenge, necessitating effective management strategies. To address this issue, pelletization technology can be employed to reduce the physical volume of …

Understanding the multidimensional effects of polymorphism, particle size and processing for D-Mannitol powders

Papers - 07/10/2022 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl

This study investigated the influence of polymorphic form, particle size, and processing of mannitol on the mechanical properties of solid oral dosage forms. The particle and powder properties of spray …

A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

Papers - 07/08/2022 - by Maarten Jaspers, Timo P. Roelofs, Pauline H.M. Janssen, Robin Meier, Bastiaan H.J. Dickhoff

Roller compaction for dry granulation is gaining popularity as a method for producing oral solid dosage forms. The process offers simplicity compared to wet granulation and operates inherently in a …

Using a model-based material sparing approach for formulation and process development of a roller compacted drug product

Papers - 26/02/2022 - by Kalyan V. Vasudevan, Yu Elaine Pu, Hossein Amini, Catherine Guarino, Anjali Agrawal, Ilgaz Akseli

This study outlines an efficient approach that integrates material profiling, Instron uniaxial die-punch testing, and a mathematical model for roller compaction to guide the formulation and process development of a …

$Laser triangulation as a fast and reliable method for determining ribbon solid fraction; focus on accuracy, precision, and measurement time$

Laser triangulation as a fast and reliable method for determining ribbon solid fraction; focus on accuracy, precision, and measurement time

Papers - 15/12/2021 - by Tim D. Lillotte, Paul Bebernik, Johanna Keck, Moritz Bommer, Daniela Schröder, Karl G. Wagner

Roller compaction and dry granulation are well-established unit operations within the pharmaceutical industry. The ribbon solid fraction, considered a critical quality attribute directly influencing final product quality and performance, is …

Roller compaction: new trends, challenges and solutions

Newsfeed - 12/11/2020 -

This article explains the 3 known technologies to develop tablets:- direct compression- wet granulation- dry granulation, with a focus on roller compaction, as it remains an effective solution for most …

Towards better understanding of the influence of process parameters in roll compaction/ dry granulation on throughput, ribbon microhardness and granule failure load

Papers - 10/11/2020 - by Annika Wilms, Peter Kleinebudde

A crucial quality aspect of solid oral dosage forms lies in their firmness and capacity to endure breaking or grinding. When aiming for continuous manufacturing, it becomes valuable to assess …

Recent progress in roll compaction process development for pharmaceutical solid dosage form manufacture

Papers - 11/06/2020 - by Ariel R. Muliadi, Alamelu Banda, Chen Mao

Over the past decade, roll compaction technologies have seen significant advancements, becoming increasingly favored by formulation scientists for granulation purposes. This chapter provides an overview of recent developments in pharmaceutical …

Roller compaction scale-up made simple: an approximate analytical solution to Johanson's rolling theory

Papers - 01/05/2020 - by Ricardo Sousa, Pedro Cardoso Valente, Mostaf Nakach, Lionel Bardet, Marie Wacquet, Noel Midoux, Jean-Rene Authelin

We derive an approximate analytical solution to Johanson's rolling theory, demonstrating that the solution produces a single dimensionless parameter that remains invariant during process scale-up or equipment transfer. This parameter …

Investigation on the effect of roller compaction on paracetamol

Papers - 02/01/2020 - by Justin Yong Soon Tay, Qi En Han, Celine Valeria Liew, Paul Wan Sia Heng

Roller compaction stands out as a widely employed dry granulation method, often linked with a decline in tabletability. This study delves into the impact of roller compaction on a model …

Elastic recovery in roll compaction simulation

Papers - 01/01/2020 - by Hannah L. Keizer, Peter Kleinebudde

Roll compaction/dry granulation stands as a widely employed method in the pharmaceutical sector for granulation. Particularly in the initial stages of solid dosage form formulation development, simulating this process is …

Model-based approach to the design of pharmaceutical roller-compaction processes

Papers - 01/12/2019 - by Peter Toson, Diogo G. Lopes, Raphael Paus, Ashish Kumar, Jeroen Geens, Sandy Stibale, Julian Quodbach, Peter Kleinebudde, Wen-Kai Hsiao, Johannes Khinast

This study introduces a novel model-based strategy for the design and scale-up of a roller compaction process within the same equipment. Instead of relying solely on in-silico predictions, the model …