Scientific papers
A relationship between crystal packing efficiency and plasticity can be utilized to rank the plasticity of different crystal forms of a compound based on their structures. It was proposed that lower packing efficiency and density result in higher plasticity for hydrates. This idea was supported by the observation that stoichiometric hydrates show both greater plasticity and lower packing efficiency compared to their anhydrate counterparts. In this study, we tested this hypothesis using a channeled hemimethanol solvate of levofloxacin acesulfame salt. Our findings reinforce the hypothesis, as the hemimethanol solvate, when compared to the isostructural anhydrate, demonstrates higher packing efficiency and lower plasticity. The reduced plasticity of the solvate is confirmed through crystal structure analysis and energy framework calculations. If this correlation between packing efficiency and plasticity holds true, we can predict the plasticity of structurally related crystals based on their packing efficiency.
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