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    Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets

    Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets

    Papers - 10/06/2022 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    Capping, a common defect in pharmaceutical tablet manufacturing, has been associated with a decrease in the unloading speed during the manufacturing cycle, as indicated by several studies. Building on this …
    Characterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique

    Characterization of the viscoelasticity of pharmaceutical tablets using impulse excitation technique

    Papers - 05/02/2022 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    The production of pharmaceutical tablets involves different types of presses, each with distinct compaction kinematics. Consequently, the strain rate sensitivity (SRS) of the powders used becomes a crucial property in …
    Characterization of tableting speed-dependent deformation properties of active pharmaceutical ingredients in powder mixtures using uut-of-die method

    Characterization of tableting speed-dependent deformation properties of active pharmaceutical ingredients in powder mixtures using uut-of-die method

    Papers - 01/12/2021 - by Daisuke Mizunaga, Mika Koseki, Naoki Kamemoto, Satoru Watano
    This study investigated a quantitative evaluation method to assess the impact of tableting speed on the compression properties of pharmaceutical powders. Cilostazol and ibuprofen served as active pharmaceutical ingredients (APIs), …
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    Lamination of pharmaceutical tablets: classification and influence of process parameters

    Papers - 23/10/2021 - by V. Mazel, P. Tchoreloff
    The occurrence of lamination is a prevalent issue in the pharmaceutical tablet manufacturing process, representing a failure of the tablet along one or more planes parallel to the surface and …
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    Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets

    Papers - 10/08/2021 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    Capping and lamination are common defects encountered in the pharmaceutical tablet manufacturing process. Numerous studies have indicated that tablet anisotropy can contribute to the occurrence of such defects. This study …
    Effect of the compaction parameters on the final structure and properties of a press-coated tablet (Tab-in-Tab): Experimental and numerical study of the influence of core and shell dimensions

    Effect of the compaction parameters on the final structure and properties of a press-coated tablet (Tab-in-Tab): Experimental and numerical study of the influence of core and shell dimensions

    Papers - 01/03/2021 - by Léo Picart, Vincent Mazel, Aline Moulin, Pierre Tchoreloff
    With the growing interest in chronopharmaceutics, press-coated tablets have emerged as a pivotal technology in the realm of modified release drug delivery systems. While considerable research has explored their advantages …
    Applicability of impulse excitation technique as a tool to characterize the elastic properties of pharmaceutical tablets: Experimental and numerical study

    Applicability of impulse excitation technique as a tool to characterize the elastic properties of pharmaceutical tablets: Experimental and numerical study

    Papers - 16/09/2020 - by Vincent Mazel, Pierre Tchoreloff
    Elastic properties play a crucial role in tablet development, particularly in formulating the composition and defining process parameters. This article introduces impulse excitation as an innovative, rapid, and cost-effective technology …
    Compression of vectors for small interfering RNAs delivery: toward oral administration of siRNA lipoplexes in tablet forms

    Compression of vectors for small interfering RNAs delivery: toward oral administration of siRNA lipoplexes in tablet forms

    Papers - 06/04/2020 - by Virginie Busignies, Danielle Campiol Arruda, Christine Charrueau, Marcela Coelho Silva Ribeiro, Anne-Marie Lachagès, Angelo Malachias, Stéphanie Finet, Asad Ur Rehman, Pascal Bigey, Pierre Tchoreloff, Virginie Escriou
    Presently, the majority of nonviral nucleic acid vectors are formulated as colloidal suspensions primarily administered parenterally. This formulation and administration method impose significant constraints, such as vector size limitations and …
    Effects of particle surface roughness on in-die flow and tableting behavior of lactose

    Effects of particle surface roughness on in-die flow and tableting behavior of lactose

    Papers - 01/09/2019 - by Justin Yong Soon Tay, Berlinda Wen Ting Kok, Celine Valeria Liew, Paul Wan Sia Heng
    The initial phase of tablet compaction involves particle rearrangement. In this investigation, rough lactose particles were created through roller compaction, and their surface roughness was altered by subjecting them to …
    Etude de la compression pharmaceutique à l'aide d'une approche de mécanique des milieux continus

    Etude de la compression pharmaceutique à l'aide d'une approche de mécanique des milieux continus

    Papers - 20/12/2018 - by Vincent Mazel
    L'ensemble de mon parcours de recherche, entamé il y a plus de 10 ans, a été centré sur la science des matériaux. J'ai eu la chance de travailler dans des …
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    Towards a better understanding of dry binder functionality

    Papers - 01/12/2018 - by Oscar-Rupert Arndt, Peter Kleinebudde
    Gaining a profound understanding of the binding behavior and functionality of different types of dry binders is crucial, as these play a pivotal role in ensuring the desirable properties of …
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    Tricalcium citrate – a new brittle tableting excipient for direct compression and dry granulation with enormous hardness yield

    Papers - 04/07/2018 - by Veronika Hagelstein, Markus Gerhart, Karl G. Wagner
    Objective: This study is dedicated to characterizing tricalcium citrate (TCC) as a tableting excipient, examining its suitability for both direct compression (DC) and dry granulation (DG). Significance: Tablets crafted from …
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    Lamination of biconvex tablets: numerical and experimental study

    Papers - 05/05/2018 - by Vincent Mazel, Harona Diarra, Jérôme Malvestio, Pierre Tchoreloff
    Capping and lamination are prevalent issues in the pharmaceutical tablet manufacturing process. Although these problems are often addressed collectively, they represent distinct failure patterns in tablets and consequently involve different …
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    Understanding the delamination risk of a trilayer tablet ssing minipiloting tools

    Papers - 01/11/2017 - by Jing Tao, Sophia Robertson-Lavalle, Preetanshu Pandey, Sherif Badawy
    One of the formulation strategies employed to address chemical and physical incompatibility among various drug substances is the use of multilayer tablets. Feasibility studies on multilayer tablets commonly utilize round …
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    Press-coated tablets increased knowledge through research

    Bulletins - 01/01/2017 -
    Comparison of compression and material properties of differently shaped and sized paracetamols

    Comparison of compression and material properties of differently shaped and sized paracetamols

    Papers - 01/01/2017 - by Michal Šimek, Veronika Grünwaldová, Bohumil Kratochvíl
    Paracetamol, a well-known Active Pharmaceutical Ingredient (API), is recognized for its unfavorable flow and compression characteristics. Traditionally, enhancing compressibility involves blending paracetamol with a substantial quantity of excipient to create …
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    Reevaluation of the diametral compression test for tablets using the flattened disc geometry

    Papers - 01/11/2016 - by V. Mazel, S. Guerard, B. Croquelois, J.B. Kopp, J. Girardot, H. Diarra, V. Busignies, P. Tchoreloff
    The assessment of mechanical strength is a crucial quality attribute for tablets in the pharmaceutical field. Traditionally, the diametral compression test has been employed for this purpose. However, concerns have …
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    Evolution of the die-wall pressure during the compression of biconvex tablets: experimental results and comparison with FEM simulation

    Papers - 01/12/2015 - by Vincent Mazel, Harona Diarra, Virginie Busignies, Pierre Tchoreloff
    Capping is a common manufacturing issue observed in tablets, with a tendency to affect biconvex tablets more than their flat-faced counterparts. One contributing factor may be the generation of higher …
    Evaluating scale-up rules of a high-shear wet granulation process

    Evaluating scale-up rules of a high-shear wet granulation process

    Papers - 01/07/2015 - by Jing Tao, Preetanshu Pandey, Dilbir S. Bindra, Julia Z. Gao, Ajit S. Narang
    This study aimed to assess the applicability of commonly employed scale-up rules for the high-shear wet granulation process, utilizing a formulation with low drug loading based on microcrystalline cellulose-lactose. Various …
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    Lamination of pharmaceutical tablets due to air entrapment: direct visualization and influence of the compact thickness

    Papers - 30/01/2015 - by V. Mazel, V. Busignies, H. Diarra, P. Tchoreloff
    Capping and lamination pose common challenges in the industrial production of pharmaceutical tablets, with various proposed reasons to explain these occurrences. Air entrapment is suggested as a potential factor in …