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    MEDELPHARM_CPHI_Nano_Demonstration

    MEDELPHARM and Armor Pharma collaborate for innovative formulation development at CPHI 2024

    Newsfeeds - 03/10/2024 -
    MEDELPHARM is excited to announce its participation at CPHI 2024 in Milan, exhibiting in collaboration with Armor Pharma, a leading manufacturer of pharmaceutical excipients. Together, they will present live demonstrations …
    Image effect of glidant on tabletting behavior

    The effect of glidant on the tabletting behavior of common pharmaceutical excipients

    Newsfeeds - 09/08/2024 -
    The article on Pharma Excipients discusses the impact of glidants on the tabletting process in pharmaceutical manufacturing. Glidants are substances added to improve the flow properties of powders during tablet …
    Merck - SEM showing highly stuctured surface area of Parteck M mannitol excipient

    Use of Mannitol as an excipient for solid drug formulation

    Newsfeeds - 16/05/2024 -
    The use of mannitol as an excipient in solid drug formulation offers several advantages, including its low hygroscopicity, inertness with respect to active pharmaceutical ingredients (APIs), and ability to produce …
    Image Excipient-based strategies to harness complex therapeutics

    Excipient-based strategies to harness complex therapeutics

    Newsfeeds - 12/03/2024 -
    The article discusses the challenges associated with small molecule drugs in pharmaceutical formulations, particularly focusing on their poor water solubility. It highlights that a significant percentage of marketed drugs and …
    round-tablets-on-yellow-background-3683057

    PEARLITOL® 200 GT Mannitol: Harnessing the potential of higher active ingredient content for smaller, more convenient tablets

    Newsfeeds - 20/02/2024 -
    The article discusses the development and optimization of PEARLITOL® 200 GT, a new pure beta mannitol grade for direct compression in tablet manufacturing. Mannitol is commonly used as an excipient …
    Lactalis Ingredients Pharma powder (from website)

    Development of pharmaceutical lactose by Lactalis Ingredients Pharma

    Newsfeeds - 12/12/2023 -
    Pharmaceutical grade lactose, used as binder or diluent, is a standard excipient for the formulation of Oral Solid Dose medicines. Versatile thanks to its various fabrication processes leading to different …
    Excipients for orally disintegrating tablets: compaction data analysis and study of tableting properties of lubricated co-processed excipients

    Excipients for orally disintegrating tablets: compaction data analysis and study of tableting properties of lubricated co-processed excipients

    Papers - 04/09/2023 - by Mayowa Onayo, Yildiz Ozalp, Nailla Jiwa, Burcu Mesut, Sevgi Gungor
    The selection of an appropriate co-processed excipient (CPE) is a critical aspect in the development of orally disintegrating tablets (ODTs). This study assessed five commonly used CPEs (Ludiflash®, Ludipress®, Ludipress® …
    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Papers - 05/04/2023 - by Pauline H.M. Janssen, Sara Fathollahi, Bram Bekaert, Dirk Vanderroost, Timo Roelofs, Valerie Vanhoorne, Chris Vervaet, Bastiaan H.J. Dickhoff
    This paper demonstrates the influence of excipient properties on both process parameters and the ultimate tablet properties in a fully integrated continuous direct compression line. The blend properties of low-dose …
    no-image

    Effect of process parameters, protectants and carrier materials on the survival of yeast cells during fluidized bed granulation for tableting

    Papers - 09/03/2023 - by Karl Vorländer, Lukas Bahlmann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    This study focuses on the drying of Saccharomyces cerevisiae, a yeast variety that includes the probiotic Saccharomyces boulardii. Ensuring microbial viability is crucial for effective dosage forms, especially for probiotics …
    Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose

    Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose

    Papers - 01/11/2022 - by Adwait Pradhan, Mark Costello, Fengyuan Yang, Vivian Bi, Thomas Durig, Feng Zhang
    With the emergence of continuous manufacturing, there has been a growing interest in the pharmaceutical industry regarding twin-screw melt granulation as a technique for co-processing excipients and developing innovative formulations. …
    Tableting Performance of Maize and Potato Starches Used in Combination as Binder/Disintegrant in Metronidazole Tablet Formulation

    Tableting performance of maize and potato starches used in combination as binder/disintegrant in Metronidazole tablet formulation

    Papers - 01/10/2022 - by Yonni Eshovo Apeji, Rejoice Thomas Kaigama, Sani Hadi Ibrahim, Sophie Nock Anyebe, Aisha Ohunene Abdussalam, Avosuahi Rukayat Oyi
    The objective of this study was to evaluate the tableting characteristics of maize and potato starches when employed either as disintegrants or binders in the development of solid dosage forms. …
    Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to Conventionally Sized Orodispersible Tablets

    Impact of lubrication on key properties of orodispersible minitablets in comparison to conventionally sized orodispersible tablets

    Papers - 05/09/2022 - by Jennifer Kuck, Jörg Breitkreutz
    Orodispersible minitablets (ODMTs) offer several advantages such as ease of swallowability, dose flexibility, and straightforward manufacturing through direct compression. This study investigates the impact of lubrication on five different co-processed …
    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    Papers - 07/08/2022 - by Maarten Jaspers, Timo P. Roelofs, Pauline H.M. Janssen, Robin Meier, Bastiaan H.J. Dickhoff
    Roller compaction for dry granulation is gaining popularity as a method for producing oral solid dosage forms. The process offers simplicity compared to wet granulation and operates inherently in a …
    PROSOLV

    The performance of PROSOLV EASYtab SP in four medium-dose, direct compression formulations with morphologically challenging model APIs

    Bulletins - 28/07/2022 -
    In the present study, the performance of PROSOLV EASYtab SP was tested in four DC formulations with different model APIs. Each of selected APIs presented a particular challenge in terms …
    Orally-disintegrating-tablets-offer-range-of-patient-benefits

    Orally disintegrating tablets offer range of patient benefits: Roquette

    Newsfeeds - 24/08/2021 -
    A leader from the excipients firm discusses how ODTs appeal to seniors and patients on the go, and the formulation-related challenges with such tablets.
    How can single particle compression and nanoindentation contribute to the understanding of pharmaceutical powder compression?

    How can single particle compression and nanoindentation contribute to the understanding of pharmaceutical powder compression?

    Papers - 01/08/2021 - by Isabell Wünsch, Stephanie Michel, Jan Henrik Finke, Edgar John, Michael Juhnke, Arno Kwade
    Understanding the deformation behavior of powder, including individual particle responses, is a critical factor in powder compaction, influencing powder compressibility and compactibility. Traditional approaches involve conducting powder compression experiments and …
    Effect of excipient particle size distribution variability on compact tensile strength; and its in-line prediction by force-displacement and force-time profiling

    Effect of excipient particle size distribution variability on compact tensile strength; and its in-line prediction by force-displacement and force-time profiling

    Papers - 12/01/2021 - by Wee Beng Lee, Effendi Widjaja, Paul Wan Sia Heng, Lai Wah Chan
    Background: The sensitivity of direct compression to the variability in particle size distribution (PSD) of pharmaceutical-grade excipients remains insufficiently explored. Additionally, the utilization of a force sensor as a process …
    Biopharmaceutical implications of excipient variability on drug dissolution from immediate release products

    Biopharmaceutical implications of excipient variability on drug dissolution from immediate release products

    Papers - 16/07/2020 - by P. Zarmpi, T. Flanagan, E. Meehan, J. Mann, J. Østergaard, N. Fotaki
    Examining the influence of excipient variability on oral product performance from a biopharmaceutical perspective could be advantageous and facilitate the integration of excipients into Quality by Design (QbD) approaches. The …
    Development of alginate esters as novel multifunctional excipients for direct compression

    Development of alginate esters as novel multifunctional excipients for direct compression

    Papers - 15/07/2020 - by Noelia M. Sanchez-Ballester, Bernard Bataille, Rihab Benabbas, Bruno Alonso, Ian Soulairol
    Evaluations have been conducted on methyl ester derivatives of alginic acid as potential multifunctional excipients for pharmaceutical direct compression. The utilization of alginic acid as an excipient in tablet formulation …
    Functionality of disintegrants with different mechanisms after roll compaction

    Functionality of disintegrants with different mechanisms after roll compaction

    Papers - 01/06/2020 - by Sabrina Berkenkemper, Hannah Lou Keizer, Marc Lindenberg, Anikó Szepes, Peter Kleinebudde
    The objective of this study was to assess the functionality of two disintegrants, namely crospovidone and croscarmellose sodium, in tablet formulations processed through roll compaction followed by tableting. The investigation …