Close search
Scientific papers

Scientific papers

Favorite Articles

    Tags

    Categories

    Authors

    34 results
    Date
    Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

    Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

    Papers - 27/11/2023 - by Dario A. Dornbierer, Laurenz Marten, Jovin Mueller, Helena D. Aicher, Michael J. Mueller, Martina Boxler, Michael Kometer, Davor Kosanic, Robin Von Rotz, Maxim Puchkov, Thomas Kraemer, Hans-Peter Landolt, Erich Seifritz, Milan Scheidegger
    Recently, the plant medicine "ayahuasca" from the Amazon, which contains the psychedelic compound N,N-dimethyltryptamine (DMT) and various β-carboline alkaloids like harmine, has been proposed as having positive effects in individuals …
    white-medication-pill-on-blue-textile-3683079.width-1200

    Characterizing drug substance properties early can optimize drug development formulation

    Newsfeeds - 23/10/2023 -
    This article examines the following key points: 1 - Early drug substance (DS) characterization is crucial as changes in the DS process can affect the drug product (DP), including purity, …
    Predictive modelling of powder compaction for binary mixtures using the finite element method

    Predictive modelling of powder compaction for binary mixtures using the finite element method

    Papers - 12/04/2022 - by Dingeman L.H. van der Haven, Frederik H. ørtoft, Kaisa Naelapää, Ioannis S. Fragkopoulos, James A. Elliott
    In the pharmaceutical industry, the formulation of tablets remains a challenging task despite the widespread adoption of solid-form drug delivery. This challenge arises from the strong dependence of tablet properties …
    Effect of binder type and lubrication method on the binder efficacy for direct compression

    Effect of binder type and lubrication method on the binder efficacy for direct compression

    Papers - 25/09/2021 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    1. Introduction: The incorporation of a binder into a direct compression formulation aims to enhance tablet tensile strength and mitigate tablet defects. The internal blending of magnesium stearate (MgSt) is …
    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Papers - 10/03/2021 - by Lise Vandevivere
    The investigation focused on evaluating the appropriateness of pharmaceutical binders for continuous twin-screw wet granulation, reflecting the pharmaceutical industry's shift from batch to continuous manufacturing. A comparison was conducted between …
    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Papers - 03/02/2021 - by Lise Vandevivere, Maxine Vangampelaere, Christoph Portier, Cedrine de Backere, Olaf Häusler, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    The appropriateness of pharmaceutical binders for continuous twin-screw wet granulation was examined, aligning with the pharmaceutical industry's transition from batch to continuous manufacturing. A scientific approach to binder selection is …
    no-image

    Recent development and complex tablet formulation design for versatile applications

    Bulletins - 31/07/2020 - by Aline Moulin, Mathieu Degomme
    In this article, Mathieu Degomme, PharmD, Pharmaceutical Development Project Manager, and Aline Moulin, PhD, Pharmaceutical Development Director, both of Skyepharma, outline three case studies from recent early-stage development programmes to …
    Along the process chain to probiotic tablets: evaluation of mechanical impacts on microbial viability

    Along the process chain to probiotic tablets: evaluation of mechanical impacts on microbial viability

    Papers - 15/01/2020 - by Karl Vorländer, Ingo Kampen, Jan Henrik Finke, Arno Kwade
    At present, probiotics are predominantly utilized in liquid or semi-solid functionalized foods, resulting in a rapid decline in cell viability. Considering the escalating issue of antibiotic resistance, probiotics hold promise …
    Simplified end-to-end continuous manufacturing by feeding API suspensions in twin-screw wet granulation

    Simplified end-to-end continuous manufacturing by feeding API suspensions in twin-screw wet granulation

    Papers - 01/12/2018 - by Adrian Schmidt, Hans de Waard, Klaus-Peter Moll, Peter Kleinebudde, Markus Krumme
    This study aimed to explore the integration of continuous manufacturing for drug substance and drug product in an end-to-end continuous manufacturing process. The key step in this integrated approach involved …
    How deformation behavior controls product performance after twin screw granulation with high drug loads and crospovidone as disintegrant

    How deformation behavior controls product performance after twin screw granulation with high drug loads and crospovidone as disintegrant

    Papers - 03/11/2016 - by Robin Meier, Klaus-Peter Moll, Markus Krumme, Peter Kleinebudde
    This study explores the quantitative impact of 12 different materials (including active pharmaceutical ingredients and excipients as surrogate active pharmaceutical ingredients) on the critical quality attributes of products generated through …
    Impact of micromeritic properties of an active pharmaceutical ingredient on its compaction behavior

    Impact of micromeritic properties of an active pharmaceutical ingredient on its compaction behavior

    Papers - 17/02/2015 - by Dilbir S. Bindra, Sridhar Desikan
    The processability of a high drug loading formulation can be notably influenced by the physical characteristics of an active pharmaceutical ingredient (API). This paper illustrates a case where distinct micromeritic …
    no-image

    Dissolution enhancement and formulation of rapid-release lornoxicam mini-tablets

    Papers - 01/08/2014 - by Hesham M. Tawfeek, Imran Y. Saleem, Matthew Roberts
    The objective was to improve the dissolution of lornoxicam (LOR) and create mini-tablets with an optimized system to achieve a fast-release multi-particulate formulation. LOR systems were prepared through co-evaporation with …
    Surfactant-mediated dissolution of metformin hydrochloride tablets: wetting effects versus ion pairs diffusivity

    Surfactant-mediated dissolution of metformin hydrochloride tablets: wetting effects versus ion pairs diffusivity

    Papers - 01/03/2014 - by Divyakant Desai, Benjamin Wong, Yande Huang, Qingmei Ye, Dan Tang, Hang Guo, Ming Huang, Peter Timmins
    The aqueous solubility of metformin (pKa: 2.8 and 11.5) within the pH range of 1.2–6.8 is 300 mg/mL, suggesting that the dissolution of metformin hydrochloride tablets should exhibit pH independence. …
    Prediction of the compressibility of complex mixtures of pharmaceutical powders

    Prediction of the compressibility of complex mixtures of pharmaceutical powders

    Papers - 05/10/2012 - by V. Busignies, V. Mazel, H. Diarra, P. Tchoreloff
    The development of predictive models for the pharmaceutical compaction process holds significant importance, not only in the formulation stage but also within the framework of Quality by Design (QbD) development. …