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    A strategy to optimize precompression pressure for tablet manufacturing based on in-die elastic recovery

    A strategy to optimize precompression pressure for tablet manufacturing based on in-die elastic recovery

    Papers - 07/03/2024 - by Gerrit Vreeman, Changquan Calvin Sun
    A strategy for optimizing precompression pressure, utilizing in-die elastic recovery, has been devised to effectively tackle tablet lamination caused by air entrapment. This approach involves intentionally intensifying the air entrapment …
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    Understanding the implication of Kawakita model parameters using in-die force-displacement curve analysis for compacted and non-compacted API powders

    Papers - 01/12/2022 - by Iyad Rashid, Rula Raji Haddadin, Ashaar Abdulsalam Alkafaween, Rawan Nayef Alkaraki, Rehan Mohammad Alkasasbeh
    The objective of this investigation was to explore powder mechanics during compression by analyzing data derived from force-displacement (F-D) curves. The study employed the Kawakita model of powder compression analysis …
    Influence of the drug deformation behaviour on the predictability of compressibility and compactibility of binary mixtures

    Influence of the drug deformation behaviour on the predictability of compressibility and compactibility of binary mixtures

    Papers - 17/08/2022 - by Isabell Wünsch, Jan Henrik Finke, Edgar John, Michael Juhnke, Arno Kwade
    Numerous studies have sought to understand the predictability of compressibility and compactibility in tablet formulations by examining the behavior of individual materials. However, the complexity of the powder compaction process …
    Evaluation of tableting performance of poly (ethylene oxide) in abuse-deterrent formulations using compaction simulation studies

    Evaluation of tableting performance of poly (ethylene oxide) in abuse-deterrent formulations using compaction simulation studies

    Papers - 15/03/2021 - by Dongyue Yu, Raghunadha Reddy Seelam, Feng Zhang, Stephen R. Byrn, Stephen W. Hoag
    Poly (ethylene oxide) (PEO) is extensively employed in abuse-deterrent formulations (ADFs) to enhance tablet hardness. Previous research has demonstrated that various formulation factors, such as processing conditions and the particle …
    Investigation of critical factors affecting mechanical characteristics of press-coated tablets using a compaction simulator

    Investigation of critical factors affecting mechanical characteristics of press-coated tablets using a compaction simulator

    Papers - 30/05/2020 - by Thi-Tram Nguyen, Hye-Ryeong Park, Cheol-Hee Cho, Kyu-Mok Hwang, Eun-Seok Park
    Press-coated tablets have become essential in chronotherapeutic drug delivery, yet limited knowledge exists about their mechanical characteristics. This study systematically explores the effects of crucial factors on tablet structure, layer …
    Elastic recovery in roll compaction simulation

    Elastic recovery in roll compaction simulation

    Papers - 01/01/2020 - by Hannah L. Keizer, Peter Kleinebudde
    Roll compaction/dry granulation stands as a widely employed method in the pharmaceutical sector for granulation. Particularly in the initial stages of solid dosage form formulation development, simulating this process is …
    Impact of die wall material on the mechanical properties of paracetamol tablets

    Impact of die wall material on the mechanical properties of paracetamol tablets

    Papers - 01/01/2020 - by Liam Chee Teh, Lai Wah Chan, Celine Valeria Liew, Paul Wan Sia Heng
    The quality of tablets can be influenced by the material, configuration, and design of tooling, comprising punches and dies. While extensive research has focused on punches, there is limited information …