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    Influence of material and process parameters on the correction factor Kp in roller compaction simulation

    Influence of material and process parameters on the correction factor Kp in roller compaction simulation

    Papers - 05/04/2025 - by Layla Hassan, René Jensen, Zahra Sodal, Frederik Hellesøe Ørtoft, Lasse I. Blaabjerg, Umair Zafar
    It is commonly accepted that compaction simulators can mimic the uniaxial compression process of roller compactors. To align the simulation output with actual product relative density, a correction factor (Kp) …
    Photo AAPS 2024 - James on KORSCH booth

    MEDELPHARM's participation at AAPS PharmSci 360 2024: Innovations in tablet formulation

    Newsfeeds - 30/10/2024 - by Gabrielle Dupont
    At the recent AAPS PharmSci 360, held from October 20th-23rd, 2024, in Salt Lake City, MEDELPHARM showcased its latest advancements in tablet formulation technology alongside KORSCH America. This collaboration featured …
    An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

    An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

    Papers - 28/10/2024 - by Yiwang Guo, Lizbeth Martinez, Arnesh Palanisamy, Bindhu Gururajan, Changquan Calvin Sun
    Ribbon porosity is essential to monitor in roller compaction. This study compares six porosity measurement methods—caliper, X-ray microtomography (µCT), near-infrared spectroscopy (NIR), laser triangulation, mercury intrusion porosimetry (MIP), and GeoPyc—using …
    tablets and powder heap

    Modified roller compaction model to account for roll speed effect on powder compaction in dry granulation process

    Papers - 07/05/2024 - by Indu Muthancheri, Mario Rousselin, Anna Espinose, Nicolas Sanchez, Jean-Rene Authelin
    This study presents an enhancement to the roller compaction model originally proposed by [1], incorporating the impact of roll speed on powder compaction during the dry granulation process. The updated …
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    Modeling of STYL'One Evolution correction factors for multicomponent mixtures scaling-up to roller compaction

    Papers - 11/04/2024 - by Fabia Arpago, Agostino Dall'Ara
    Roll compaction (RC) stands as a cost-efficient dry granulation technique extensively utilized in the pharmaceutical sector. In the initial stages of formulation development, particularly when resources are constrained, the ability …
    Elucidating the Impact of Material Properties on Tablet Manufacturability for Binary Paracetamol Blends

    Elucidating the impact of material properties on tablet manufacturability for binary paracetamol blends

    Papers - 17/11/2023 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    Objective: While the mechanical properties of paracetamol and microcrystalline cellulose (MCC) are well-documented in the literature, there is a recognized need for a more nuanced understanding of the material properties …
    A study on the pelletization and solidification of Cs-contaminated soil after soil washing

    A study on the pelletization and solidification of Cs-contaminated soil after soil washing

    Papers - 01/06/2023 - by Jun-Yeol An, Ki-Tae Yang, Min-Ho Lee, Sang-Hyun Lim, Sun-Il Kim, Jong-Soon Song
    The release of radioactive substances during a nuclear power plant accident can result in soil contamination over a wide area. Soil washing, employed as a decontamination technique for cesium (Cs)-contaminated …
    Solidification of radioactive soil waste through volume reduction and stabilization: Characteristic evaluation and waste acceptance criteria satisfaction

    Solidification of radioactive soil waste through volume reduction and stabilization: Characteristic evaluation and waste acceptance criteria satisfaction

    Papers - 01/05/2023 - by Sang-Hyun Lim, Sang-Heon Lee, Jong-Soon Song, Ki-Hong Kim
    The disposal of radioactive soil waste poses a global environmental challenge, necessitating effective management strategies. To address this issue, pelletization technology can be employed to reduce the physical volume of …
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    Understanding the multidimensional effects of polymorphism, particle size and processing for D-Mannitol powders

    Papers - 07/10/2022 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    This study investigated the influence of polymorphic form, particle size, and processing of mannitol on the mechanical properties of solid oral dosage forms. The particle and powder properties of spray …
    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    Papers - 07/08/2022 - by Maarten Jaspers, Timo P. Roelofs, Pauline H.M. Janssen, Robin Meier, Bastiaan H.J. Dickhoff
    Roller compaction for dry granulation is gaining popularity as a method for producing oral solid dosage forms. The process offers simplicity compared to wet granulation and operates inherently in a …
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    Using a model-based material sparing approach for formulation and process development of a roller compacted drug product

    Papers - 26/02/2022 - by Kalyan V. Vasudevan, Yu Elaine Pu, Hossein Amini, Catherine Guarino, Anjali Agrawal, Ilgaz Akseli
    This study outlines an efficient approach that integrates material profiling, Instron uniaxial die-punch testing, and a mathematical model for roller compaction to guide the formulation and process development of a …
    Laser triangulation as a fast and reliable method for determining ribbon solid fraction; focus on accuracy, precision, and measurement time

    Laser triangulation as a fast and reliable method for determining ribbon solid fraction; focus on accuracy, precision, and measurement time

    Papers - 15/12/2021 - by Tim D. Lillotte, Paul Bebernik, Johanna Keck, Moritz Bommer, Daniela Schröder, Karl G. Wagner
    Roller compaction and dry granulation are well-established unit operations within the pharmaceutical industry. The ribbon solid fraction, considered a critical quality attribute directly influencing final product quality and performance, is …
    BRC_100_033 - L.B. Bohle

    Roller compaction: new trends, challenges and solutions

    Newsfeeds - 12/11/2020 -
    This article explains the 3 known technologies to develop tablets:- direct compression- wet granulation- dry granulation, with a focus on roller compaction, as it remains an effective solution for most …
    Towards better understanding of the influence of process parameters in roll compaction/ dry granulation on throughput, ribbon microhardness and granule failure load

    Towards better understanding of the influence of process parameters in roll compaction/ dry granulation on throughput, ribbon microhardness and granule failure load

    Papers - 10/11/2020 - by Annika Wilms, Peter Kleinebudde
    A crucial quality aspect of solid oral dosage forms lies in their firmness and capacity to endure breaking or grinding. When aiming for continuous manufacturing, it becomes valuable to assess …
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    Recent progress in roll compaction process development for pharmaceutical solid dosage form manufacture

    Papers - 11/06/2020 - by Ariel R. Muliadi, Alamelu Banda, Chen Mao
    Over the past decade, roll compaction technologies have seen significant advancements, becoming increasingly favored by formulation scientists for granulation purposes. This chapter provides an overview of recent developments in pharmaceutical …
    Roller compaction scale-up made simple: an approximate analytical solution to Johanson's rolling theory

    Roller compaction scale-up made simple: an approximate analytical solution to Johanson's rolling theory

    Papers - 01/05/2020 - by Ricardo Sousa, Pedro Cardoso Valente, Mostaf Nakach, Lionel Bardet, Marie Wacquet, Noel Midoux, Jean-Rene Authelin
    We derive an approximate analytical solution to Johanson's rolling theory, demonstrating that the solution produces a single dimensionless parameter that remains invariant during process scale-up or equipment transfer. This parameter …
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    Investigation on the effect of roller compaction on paracetamol

    Papers - 02/01/2020 - by Justin Yong Soon Tay, Qi En Han, Celine Valeria Liew, Paul Wan Sia Heng
    Roller compaction stands out as a widely employed dry granulation method, often linked with a decline in tabletability. This study delves into the impact of roller compaction on a model …
    Elastic recovery in roll compaction simulation

    Elastic recovery in roll compaction simulation

    Papers - 01/01/2020 - by Hannah L. Keizer, Peter Kleinebudde
    Roll compaction/dry granulation stands as a widely employed method in the pharmaceutical sector for granulation. Particularly in the initial stages of solid dosage form formulation development, simulating this process is …
    Model-based approach to the design of pharmaceutical roller-compaction processes

    Model-based approach to the design of pharmaceutical roller-compaction processes

    Papers - 01/12/2019 - by Peter Toson, Diogo G. Lopes, Raphael Paus, Ashish Kumar, Jeroen Geens, Sandy Stibale, Julian Quodbach, Peter Kleinebudde, Wen-Kai Hsiao, Johannes Khinast
    This study introduces a novel model-based strategy for the design and scale-up of a roller compaction process within the same equipment. Instead of relying solely on in-silico predictions, the model …
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    Parameter estimation for roller compaction process using an instrumented vector TF mini roller compactor

    Papers - 26/11/2019 - by Jay Poorna Reddy, Rahul Phanse, Vishwas Nesarikar
    Utilizing instrumented roll technology, statistical models were constructed to establish relationships between process parameters—such as hydraulic pressure, roll speed, and screw speed of the Vector TF mini roller compactor—and ribbon …