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    Influence of multiple compression phases during tableting of spray dried Saccharomyces cerevisiae on microbial survival and physical–mechanical tablet properties

    Influence of multiple compression phases during tableting of spray dried Saccharomyces cerevisiae on microbial survival and physical–mechanical tablet properties

    Papers - 18/11/2024 - by Karl Vorländer, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    The viability of probiotic microorganisms is critical for their health benefits and must be carefully preserved throughout the production of final dosage forms, such as tablets. This includes processes like …
    Evaluation of binders in twin-screw wet granulation – Optimization of tabletability

    Evaluation of binders in twin-screw wet granulation – Optimization of tabletability

    Papers - 25/06/2024 - by Claudia Köster, Peter Kleinebudde
    This study examined the impact of hydroxypropyl cellulose (HPC) type (HPC-SSL SFP, HPC-SSL), binder concentration (2%, 3.5%, 5%), and filler type (lactose, or calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on …
    Effect of compression process parameters on the physical properties and in vitro release mechanism of the press-coated nifedipine matrix sustained-release tablets

    Effect of compression process parameters on the physical properties and in vitro release mechanism of the press-coated nifedipine matrix sustained-release tablets

    Papers - 01/11/2023 - by Yibin Guo, Peifu Xiao, Heyang Dong, Xueting Guo, Tian Yin, Yu Zhang, Haibing He, Yanjiao Wang, Jingxin Gou, Xing Tang
    Our objective is to elucidate the impact of compression process parameters on the physical characteristics and release kinetics of press-coated tablets (PCTs) with dual reservoirs. The critical compression force, marking …
    Prediction of the Tensile Strength of Tablets Using LSTM Networks on Compression Profiles

    Prediction of the tensile strength of tablets using LSTM networks on compression profiles

    Papers - 28/07/2023 - by Jill De Bisshop, Stefan Klinken
    The primary aim of this publication was to anticipate tablet tensile strength by analyzing process data, including compression pressure, sampling timestamps, and punch positions. A recurrent neural network, specifically incorporating …
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    Structural and functional analysis of a new co-processed tableting excipient for food compaction processes

    Papers - 20/06/2023 - by René Rösemeier-Scheumann, Lars Wagner, Ulrich Bobe, Annabel Bozon, Arno Kwade, Jan Henrik Finke
    Food compacts offer convenience to both the industry and customers, necessitating a robust strength to endure the rigors of packaging processes and customer handling. Unlike pharmaceutical applications, where excipient choices …
    Evaluation of binders in twin-screw wet granulation – Optimal combination of binder and disintegrant

    Evaluation of binders in twin-screw wet granulation – Optimal combination of binder and disintegrant

    Papers - 01/05/2023 - by Claudia Köster, Peter Kleinebudde
    The study explored the effects of the localization (intragranular, split, or extragranular) of three superdisintegrants (croscarmellose sodium, crospovidone, sodium starch glycolate) on granules and tablets produced through twin-screw granulation. The …
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    Production challenges of tablets containing lipid excipients: Case study using cannabidiol as drug model

    Papers - 25/02/2023 -
    The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and inorganic carriers (colloidal …
    Influence of the drug deformation behaviour on the predictability of compressibility and compactibility of binary mixtures

    Influence of the drug deformation behaviour on the predictability of compressibility and compactibility of binary mixtures

    Papers - 17/08/2022 - by Isabell Wünsch, Jan Henrik Finke, Edgar John, Michael Juhnke, Arno Kwade
    Numerous studies have sought to understand the predictability of compressibility and compactibility in tablet formulations by examining the behavior of individual materials. However, the complexity of the powder compaction process …
    A powder tabletability equation

    A powder tabletability equation

    Papers - 12/07/2022 - by Gerrit Vreeman, Changquan Calvin Sun
    A formula depicting the tensile strength of tablets in relation to compaction pressure was developed based on the equations proposed by Ryshkewitch and Kuentz-Leuenberger. This equation was employed to model …
    Effect of excipient particle size distribution variability on compact tensile strength; and its in-line prediction by force-displacement and force-time profiling

    Effect of excipient particle size distribution variability on compact tensile strength; and its in-line prediction by force-displacement and force-time profiling

    Papers - 12/01/2021 - by Wee Beng Lee, Effendi Widjaja, Paul Wan Sia Heng, Lai Wah Chan
    Background: The sensitivity of direct compression to the variability in particle size distribution (PSD) of pharmaceutical-grade excipients remains insufficiently explored. Additionally, the utilization of a force sensor as a process …
    Influence of the porosity of cushioning excipients on the compaction of coated multi-particulates

    Influence of the porosity of cushioning excipients on the compaction of coated multi-particulates

    Papers - 01/07/2020 - by Ramy N. Elsergany, Lai Wah Chan, Paul Wan Sia Heng
    Compacting tablets in a multiple unit-pellet system (MUPS) presents significant challenges due to potential damage to the functional polymer coat and the risk of pellet segregation during the tableting process. …
    Effect of particle size on powder compaction and tablet strength using limestone

    Effect of particle size on powder compaction and tablet strength using limestone

    Papers - 01/03/2020 - by Ramon Cabiscol, Hao Shi, Isabell Wünsch, Vanessa Magnanimo, Jan Henrik Finke, Stefan Luding, Arno Kwade
    The compaction of powders at high loads poses a challenge due to the simultaneous occurrence of particle rearrangement, compression, and breakage. Although tableting is a pivotal process in pharmaceutical technology, …
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    Impact of different dry and wet granulation techniques on granule and tablet properties: a comparative study

    Papers - 01/12/2018 - by Oscar-Rupert Arndt, Roberto Baggio, Anna Kira Adam, Julia Harting, Erica Franceschinis, Peter Kleinebudde
    A comparative analysis was conducted on four granulation techniques to assess their impact on granule properties and tablet tensile strength. A common formulation was selected for processing through wet and …
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    Comparison of the performance of single punch and rotary tablet presses from different vendors

    Bulletins - 04/04/2018 - by Maren Zimmermann, Gerhard Schaldach, Annette Bauer-Brandl, Peter Kleinebudde
    As tablets are the most common dosage form for drug delivery, many different rotary presses are available on the market in order to produce tablets with a high throughput. Single …
    Reevaluation of the diametral compression test for tablets using the flattened disc geometry

    Reevaluation of the diametral compression test for tablets using the flattened disc geometry

    Papers - 01/11/2016 - by V. Mazel, S. Guerard, B. Croquelois, J.B. Kopp, J. Girardot, H. Diarra, V. Busignies, P. Tchoreloff
    The assessment of mechanical strength is a crucial quality attribute for tablets in the pharmaceutical field. Traditionally, the diametral compression test has been employed for this purpose. However, concerns have …
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    Predictive model for tensile strength of pharmaceutical tablets based on local hardness measurements

    Papers - 01/07/2015 - by Audrey Juban, Cécile Nouguier-Lehon, Stéphanie Briancon, Thierry Hoc, François Puel
    In the pharmaceutical domain, tablets stand out as the most prevalent dosage forms for oral administration. The manufacturing process of tablets incorporates measures to ensure their mechanical strength, preventing crumbling …
    Comparison of different failure tests for pharmaceutical tablets: Applicability of the Drucker–Prager failure criterion

    Comparison of different failure tests for pharmaceutical tablets: Applicability of the Drucker–Prager failure criterion

    Papers - 01/08/2014 - by Vincent Mazel, Harona Diarra, Virginie Busignies, Pierre Tchoreloff
    Various tests can be employed to examine the strength of pharmaceutical tablets. Equations are available in the literature to convert the measured failure force into a failure stress, which can …
    Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface

    Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface

    Papers - 15/05/2014 - by Tanja Stirnimann, Susanna Atria, Joachim Schoelkopf, Patrick A. C. Gane, Rainer Alles, Jörg Huwyler, Maxim Puchkov
    In this study, our objective was to characterize the compressibility and compactibility of a novel pharmaceutical excipient known as functionalized calcium carbonate (FCC). We investigated three different modifications of FCC …
    Evaluation of a rotary tablet press simulator as a tool for the characterization of compaction properties of pharmaceutical products

    Evaluation of a rotary tablet press simulator as a tool for the characterization of compaction properties of pharmaceutical products

    Papers - 01/06/2010 - by F. Michaut, V. Busignies, C. Fouquereau, B. Huet de Barochez, B. Leclerc, P. Tchoreloff
    The Stylcam 100R, designed as a rotary press simulator to replicate speed profiles of rotary tablet presses, has undergone qualification by various laboratories. However, its suitability for investigating powder behavior …