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Determination of surface energies of hot-melt extruded sugar–starch pellets

Papers - 07/02/2018 - by Chi-Wah Yeung, Hubert Rein

Hot-melt extruded sugar–starch pellets present an alternative to conventional sugar spheres, yet their coating properties require further investigation. The European Pharmacopoeia 8.6 and the United States Pharmacopeia 40 outline the …

Wetting effects versus ion pairs diffusivity: Interactions of anionic surfactants with highly soluble cationic drugs and its impact on tablet dissolution

Papers - 01/07/2015 - by Divyakant Desai, Benjamin Wong, Yande Huang, Qingmei Ye, Hang Guo, Ming Huang, Peter Timmins

A study was undertaken to gain a mechanistic understanding of the dissolution of metformin hydrochloride, a highly soluble cationic drug, in the presence of anionic surfactants known as sodium alkyl …

Surfactant-mediated dissolution of metformin hydrochloride tablets: wetting effects versus ion pairs diffusivity

Surfactant-mediated dissolution of metformin hydrochloride tablets: wetting effects versus ion pairs diffusivity

Papers - 01/03/2014 - by Divyakant Desai, Benjamin Wong, Yande Huang, Qingmei Ye, Dan Tang, Hang Guo, Ming Huang, Peter Timmins

The aqueous solubility of metformin (pKa: 2.8 and 11.5) within the pH range of 1.2–6.8 is 300 mg/mL, suggesting that the dissolution of metformin hydrochloride tablets should exhibit pH independence. …