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    In-line porosity and hardness monitoring of tablets by means of optical coherence tomography

    In-line porosity and hardness monitoring of tablets by means of optical coherence tomography

    Papers - 12/05/2024 - by Elisabeth Fink, Selma Celikovic, Rúben Martins Fraga, Johan Remmelgas, Jakob Rehrl, Johannes Khinast
    "Monitoring critical quality attributes (CQAs) in-line during the tableting process is crucial for implementing a real-time release strategy. CQAs such as tablet mass, API content, dissolution, hardness, and tensile strength …
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    A review on formulation of effervescent tablet

    Papers - 01/04/2023 -
    The effervescent tablets are formulated by various methods like wet granulation and dry granulation. One of the most popular ways of administering a medicament is by converting it to its …
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    Usage of compaction simulators for the powder compression characterization – advantages and limitations

    Papers - 26/12/2022 - by Nenad Nikolić, Tijana Miletić, Jovana Kovačević, Djorđe Medarević, Svetlana Ibrić
    Compaction simulators are crafted as machines capable of conducting a thorough analysis of the powder compaction process. The detailed examination of powder compression and compaction, along with material characterization, assumes …
    Compression profiles of a directly compressible starch using compaction simulation and high-speed tablet press

    Compression profiles of a directly compressible starch using compaction simulation and high-speed tablet press

    Papers - 12/05/2021 - by Jessica Tran-Dinh, Manish Rane, Ali Rajabi-Siahboomi, Matthew Roberts, Gökçehan Pürsöken
    Starch-based excipients are commonly employed in the creation of solid oral formulations due to their properties as binders, fillers, or disintegrants. Maize starches, chosen for their inert and stable nature …
    Critical tools in tableting research: using compaction simulator and Quality by Design (QbD) to evaluate lubricants’ effect in direct compressible formulation

    Critical tools in tableting research: using compaction simulator and Quality by Design (QbD) to evaluate lubricants’ effect in direct compressible formulation

    Papers - 11/05/2021 - by Nailla Jiwa, Yildiz Ozalp, Gizem Yegen, Buket Aksu
    As widely acknowledged, the product development phase is intricate, demanding a depth of knowledge and substantial time investment. The meticulous selection of excipients, considering their appropriate functionalities and corresponding levels, …
    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Papers - 03/02/2021 - by Lise Vandevivere, Maxine Vangampelaere, Christoph Portier, Cedrine de Backere, Olaf Häusler, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    The appropriateness of pharmaceutical binders for continuous twin-screw wet granulation was examined, aligning with the pharmaceutical industry's transition from batch to continuous manufacturing. A scientific approach to binder selection is …
    Starch-based controlled release matrix tablets: impact of the type of starch

    Starch-based controlled release matrix tablets: impact of the type of starch

    Papers - 20/10/2020 - by D. Elgaied-Lamouchi, N. Descamps, P. Lefevre, I. Rambur, J.-Y. Pierquin, F. Siepmann, J. Siepmann, S. Muschert
    Various starch types were employed in the formulation of controlled release tablets containing diprophylline through direct compression. The study explored the influence of starch's natural origin, potential chemical modifications (such …
    Polyglycerol esters of fatty acids as safe and stable matrix forming tableting excipients: a structure-function analysis

    Polyglycerol esters of fatty acids as safe and stable matrix forming tableting excipients: a structure-function analysis

    Papers - 01/08/2020 - by Sharareh Salar Behzadi, Julia Karrer, Valon Demiri, Brenda Barrios, Carolina Corzo, Claudia Meindl, Dirk Lochmann, Sebastian Reyer
    This study introduces an innovative approach to developing stable extended-release matrix tablets through direct compaction. The chosen molecules belong to polyglycerol esters of fatty acids (PGFAs), a category of lipid-based …
    High-molecular-weight hypromellose from three different suppliers: effects of compression speed, tableting equipment, and moisture on the compaction

    High-molecular-weight hypromellose from three different suppliers: effects of compression speed, tableting equipment, and moisture on the compaction

    Papers - 01/07/2020 - by Peter Grdešič, Amrit Paudel, Ilija German Ilić
    The increasing significance of higher tableting speeds in the pharmaceutical industry prompts a need for comprehensive studies on the mechanical properties of hypromellose. Surprisingly, there is a lack of recent …
    Robustness of controlled release tablets based on a cross-linked pregelatinized potato starch matrix

    Robustness of controlled release tablets based on a cross-linked pregelatinized potato starch matrix

    Papers - 01/07/2020 - by D. Elgaied-Lamouchi, N. Descamps, P. Lefèvre, A. R. Mackin-Mohamour, C. Neut, F. Siepmann, Juergen Siepmann, S. Muschert
    The objective of this research was to assess the viability of utilizing cross-linked pregelatinized potato starch (marketed as PREGEFLO ® PI10) as a matrix former for controlled release tablets. Various …
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    Quantification of tablet sensitivity to a stress concentration: generalization of Hiestand's approach and link with the microstructure

    Papers - 01/06/2020 - by B. Croquelois, J. Girardot, J.B. Kopp, P. Tchoreloff, V. Mazel
    The sensitivity to stress concentration is a crucial factor in the development of pharmaceutical tablets, given its association with defects such as capping. Hiestand et al. introduced the Brittle Fracture …
    A facile and novel approach to manufacture paclitaxel-loaded proliposome tablet formulations of micro or nano vesicles for nebulization

    A facile and novel approach to manufacture paclitaxel-loaded proliposome tablet formulations of micro or nano vesicles for nebulization

    Papers - 01/06/2020 - by Iftikhar Khan, Katie Lau, Ruba Bnyan, Chahinez Houacine, Matthew Roberts, Abdullah Isreb, Abdelbary Elhissi, Sakib Yousaf
    Objective: This study aimed to develop innovative paclitaxel-loaded proliposome tablet formulations for pulmonary drug delivery. Methodology: Various proliposome powder formulations (F1–F27) were prepared, utilizing Lactose monohydrate (LMH), Microcrystalline cellulose (MCC), …