4 strategies to formulate poorly soluble APIs

March 01, 2024

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The text discusses strategies employed by researchers and pharmaceutical scientists to address the challenge of poor solubility in APIs. It outlines four main techniques: lipid-based formulations, amorphous solid dispersions, nanotechnology, and particle engineering. Lipid-based formulations utilize hydrophobic lipids to enhance solubility and bioavailability. Amorphous solid dispersions involve turning crystalline APIs into amorphous forms using polymers or non-polymeric carriers. Nanotechnology aims to increase surface area for improved solubility, while particle engineering alters particle size and morphology. Each technique has advantages and challenges, and ongoing research is crucial for further advancements in addressing poorly soluble APIs. The author, Rajendran (Raj) Arunagiri, emphasizes the importance of continued research and investment in this area to improve human health.