Customized release through dispersed dosage formats

October 30, 2025

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The article from Adare Pharma Solutions explores the development of customized oral dosage forms designed to improve both therapeutic performance and patient acceptance. Dr. Nathan Dormer highlights that while traditional tablets and capsules are effective, dispersed dosage formats—such as powders, granules, and multiparticulates—offer distinct advantages for tailoring drug release profiles. These formats allow for modified, controlled, or delayed release, helping maintain consistent drug plasma levels and improving efficacy, particularly for drugs with narrow therapeutic windows.

A key focus is patient-centric formulation. Dispersed formats can be easier to swallow, allow for flexible dosing, and can be incorporated into foods or beverages, enhancing compliance, especially in populations like pediatrics or geriatrics. The article emphasizes that successful development requires careful material selection, understanding of physicochemical properties, and process optimization to ensure uniformity, stability, and consistent performance.

Additionally, Adare discusses the challenges associated with manufacturing dispersed dosage forms, such as flowability, content uniformity, and scale-up, and how innovative formulation and process strategies can overcome these hurdles. By combining scientific expertise with patient-focused design, dispersed dosage formats provide a versatile platform to meet both regulatory requirements and market expectations.

Overall, the document underscores that customized release through dispersed formats represents a powerful approach to maximize therapeutic outcomes while prioritizing patient convenience and adherence.