Compaction simulation with KORSCH and MEDELPHARM

September 18, 2024

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Compaction simulation technology plays a critical role in developing pharmaceutical dosage forms for high-speed tablet production. MEDELPHARM's STYL’One compaction simulators optimize the blend of active pharmaceutical ingredients (APIs) and excipients, and refine the compression process. These simulators address challenges like limited API samples in early development and scale-up phases by offering material-saving approaches.

Compaction simulators, which have evolved since the 1970s, now offer advanced capabilities for analyzing materials, understanding compression behavior, and troubleshooting production processes. Modern simulators replicate the compression kinetics of high-speed production tablet presses, using highly controlled punch displacement profiles and advanced instrumentation to monitor and analyze the compression process.

The STYL’One Evo, a versatile electro-mechanical compaction simulator, can simulate various tablet press processes, including multilayer and dry granulation studies. It is controlled by the ANALIS software, which collects, analyzes, and visualizes data to support tablet development and production. MEDELPHARM continues to innovate in this field, offering solutions like the STYL’One Nano benchtop unit for entry-level needs and containment options for handling potent APIs.