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NEWSFEEDS

Improving API solubility using hot melt extrusion formulation with polyvinyl alcohol

July 22, 2025
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The article from Pharmaceutical Online explores how hot melt extrusion (HME) using polyvinyl alcohol (PVA) can significantly improve the solubility and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).

Poor solubility is a major challenge in drug development, often limiting the therapeutic efficacy of small-molecule drugs. HME addresses this by dispersing the API into a polymer matrix—in this case, PVA—creating a stable amorphous solid dispersion that dissolves more readily than its crystalline form. PVA is particularly effective due to its biocompatibility, film-forming properties, and ability to provide consistent drug release.

MilliporeSigma’s research highlights how different grades of Parteck® MXP PVA influence melt behavior and drug dissolution, showing how formulation choices can be tailored to optimize performance. HME is also a solvent-free, continuous, and scalable process, making it highly suitable for modern pharmaceutical manufacturing.

Overall, combining HME with PVA offers formulators a robust and efficient strategy to enhance the solubility and manufacturability of challenging APIs.

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Improving API Solubility Using Hot Melt Extrusion Formulation With Polyvinyl Alcohol
solubility hot melt extrusion amorphous solid dispersion
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