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    System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes

    System model driven selection of robust tablet manufacturing processes based on drug loading and formulation physical attributes

    Papers - 01/05/2022 - by Leah R. White, Matthew Molloy, Robert J. Shaw, Gavin K. Reynolds
    Utilizing mechanistic process modeling offers an opportunity to alleviate experimental demands, allowing for the establishment of relationships between process parameters and product attributes through in-silico experiments. A system model for …
    first-impressions-tablet-shape-can-impact-2

    First impressions: tablet shape can impact patient acceptance

    Newsfeeds - 24/11/2020 -
    The article discusses the crucial role of tablet design in shaping consumer perception and acceptance, particularly in pharmaceutical, nutritional, and confectionary industries. It highlights the limitations of the flat faced …
    Model-based approach to the design of pharmaceutical roller-compaction processes

    Model-based approach to the design of pharmaceutical roller-compaction processes

    Papers - 01/12/2019 - by Peter Toson, Diogo G. Lopes, Raphael Paus, Ashish Kumar, Jeroen Geens, Sandy Stibale, Julian Quodbach, Peter Kleinebudde, Wen-Kai Hsiao, Johannes Khinast
    This study introduces a novel model-based strategy for the design and scale-up of a roller compaction process within the same equipment. Instead of relying solely on in-silico predictions, the model …
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    Parameter estimation for roller compaction process using an instrumented vector TF mini roller compactor

    Papers - 26/11/2019 - by Jay Poorna Reddy, Rahul Phanse, Vishwas Nesarikar
    Utilizing instrumented roll technology, statistical models were constructed to establish relationships between process parameters—such as hydraulic pressure, roll speed, and screw speed of the Vector TF mini roller compactor—and ribbon …
    A study on compaction punch design on tablet properties

    A study on compaction punch design on tablet properties

    Papers - 01/01/2017 - by Parthiban Anbalagan
    The evolution of tablet compaction punches has seen various design modifications aimed at enhancing manufacturing efficiency, tablet quality, and tool durability. This study seeks to comprehend the impact of developing …
    Roller compaction process development and scale up using Johanson model calibrated with instrumented roll data

    Roller compaction process development and scale up using Johanson model calibrated with instrumented roll data

    Papers - 01/10/2012 - by Vishwas V. Nesarikar, Chandrakant Patel, William Early, Nipa Vatsaraj, Omar Sprockel, Robert Jerzweski
    Roller compaction serves as a dry granulation process transforming powder blends into freely flowing agglomerates. When expanding or transferring the roller compaction process, maintaining comparable ribbon densities across scales becomes …
    Instrumented roll technology for the design space development of roller compaction process

    Instrumented roll technology for the design space development of roller compaction process

    Papers - 01/04/2012 - by Vishwas V. Nesarikar, Nipa Vatsaraj, Chandrakant Patel, William Early, Preetanshu Pandey, Omar Sprockel, Zhihui Gao, Robert Jerzewski, Ronald Miller, Michael Levin
    The Alexanderwerk® WP120 roller compactor incorporates instrumented roll technology, which was successfully developed and applied for measuring normal stress on the ribbon throughout the compaction process. The study investigated the …